Názov bunkovej línie | Prírastkové číslo | Rodičovská bunková línia | Odvodené bunkové línie | Druh pôvodcu (slov.) | Druh pôvodcu (lat.) | Z hľadiska ľudského pôvodcu | Z hľadiska etickosti získania | Synonymá | Skupina | Transformácie [1] | Transfekcie [2] | Kategória | Typ buniek | Pohlavie bunky | Dospelosť buniek vzorky | Vek buniek vzorky | Poznámky | Publikácie | Web |
4647 | CVCL_4075 | / | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | Continuous kidney cell line No. 4647 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | neurčené | dospelé | / | Group: Non-human primate cell line. | PubMed=6495709 Mironova L.L., Kurbatov A.V., Grachev V.P., Kuznetsova N.V., Stobetskii V.I. Continuous kidney cell line No. 4647 from an adult green monkey and its use in virological practice. Vopr. Virusol. 29:503-506(1984) PubMed=3445593 Mironova L.L., Shalunova N.V., Lomanova G.A., Nikolaeva M.A., Khapchaev I.K. Characteristics of a bank of the heteroploid kidney cell line 4647 from the green monkey. Vopr. Virusol. 32:740-743(1987) PubMed=2175469 Isaenko A.A., Nemtsov I.V., Tsareva A.A. A karyotype study of the cells of the African green monkey kidney cell line 4647 cultured long term in media with different sera. Tsitologiia 32:736-740(1990) PubMed=17500238 Skarnovich M.O., Radaeva I.F., Vdovichenko G.V., Nechaeva E.A., Sergeev A.A., Petrishchenko V.A., Pliasunov I.V., Shishkina L.N., Ternovoi V.A., Smetannikova M.A., Agafonov A.P., Sergeev A.N. 4647-cell culture for preparation of recombinant bivaccine against smallpox and hepatitis B. Vopr. Virusol. 52:37-40(2007) | http://www.cellresource.cn/fdetail.aspx?id=529 |
A-549 | CVCL_0023 | Áno | CVCL_UJ32 (A549 ATGL-KO) CVCL_VR73 (A549 dCas9-KRAB) CVCL_YZ46 (A549 DHODH-/-) CVCL_JK07 (A549 EML4-ALK) CVCL_RT13 (A549 GFP-EGFR) CVCL_RQ89 (A549 GFP-STAT1) CVCL_RX08 (A549 L2A6) CVCL_RX09 (A549 L2G9) CVCL_LB65 (A549 MX10) CVCL_DF39 (A549 NucLight Green) CVCL_DF40 (A549 NucLight Red) CVCL_XY99 (A549 OS8) CVCL_LI35 (A549 VIM RFP) CVCL_4V06 (A549(VM)28) CVCL_4V07 (A549(VP)28) CVCL_XE67 (A549-5Fu) CVCL_XE68 (A549-Cas9-538) CVCL_IP03 (A549-CR) CVCL_5I73 (A549-Dual) CVCL_XB31 (A549-EGFP) CVCL_QZ76 (A549-eGFP-Puro) CVCL_XI06 (A549-ESM) CVCL_QZ77 (A549-Fluc-Neo/eGFP-Puro) CVCL_QZ78 (A549-Fluc-Neo/iRFP-Puro) CVCL_QZ79 (A549-Fluc-Puro) CVCL_QZ80 (A549-hNIS-Neo) CVCL_QZ81 (A549-hNIS-Neo/eGFP-Puro) CVCL_QZ82 (A549-hNIS-Neo/Fluc-Puro) CVCL_QZ83 (A549-hNIS-Neo/iRFP-Puro) CVCL_QZ84 (A549-iRFP-Neo) CVCL_QZ85 (A549-iRFP-Puro) CVCL_J242 (A549-Luc) CVCL_5J13 (A549-luc-C8) CVCL_UR31 (A549-Luc2) CVCL_XE69 (A549-Luc2-tdT-2) CVCL_XB30 (A549-mCherry) CVCL_5I86 (A549-Red-FLuc) CVCL_W218 (A549-Taxol) CVCL_XB27 (A549-tdT) CVCL_4Z15 (A549.EpoB40) CVCL_IY87 (A549/8) CVCL_YA87 (A549/Asc-1) CVCL_H268 (A549/CPT) CVCL_JY87 (A549/GFP) CVCL_KS36 (A549/NFkB-luc) CVCL_UJ49 (A549/SF) CVCL_W190 (A549/TXL10) CVCL_W191 (A549/TXL20) CVCL_W192 (A549/TXL5) CVCL_ZX73 (A549L0) CVCL_RQ47 (A549rCDDP2000) CVCL_U656 (AE1-2a) CVCL_8470 (AE1201) CVCL_KV97 (InCELL Hunter A549 EP300 Bromodomain) CVCL_KV98 (InCELL Hunter A549 G9a Methyltransferase) CVCL_KV99 (InCELL Hunter A549 GLP Methyltransferase) CVCL_KW00 (InCELL Hunter A549 PRMT3 Methyltransferase) CVCL_5992 (JHU-028) CVCL_W340 (K209) CVCL_ZI99 (LanthaScreen ATF2 (19-106) A549) CVCL_YJ75 (LINTERNA A549) CVCL_A9P0 (NF-KappaB reporter (Luc)-A549) CVCL_5J44 (p53-RE-luc/A549) CVCL_KW16 (PathHunter A549 IkappaB Degradation) CVCL_TZ89 (SL0003) CVCL_TZ90 (SL0006) | človek | Homo sapiens | ľudská | etická | A 549; A549; NCI-A549; A549/ATCC; A549 ATCC; A549ATCC; hA549 | Bunková línia využívaná pri produkcii vakcín | / | / | Rakovinové bunkové línie | pľúcny kacinóm | mužské | dospelé | 58 rokov | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 2. Part of: JFCR39 cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Part of: NCI-60 cancer cell line panel. Part of: NCI-7 clinical proteomics reference material cell line panel. Population: Caucasian. Doubling time: 18 hours (in RPMI 1640 + 10% FBS), 37 hours (in ACL-3), 36 hours (in ACL-3+BSA) (PubMed=3940644); 27.0 hours (PubMed=8286010); 22 hours (PubMed=25984343); 23.9 hours (PubMed=29681454); 27 hours (from cell counting), 27 hours (from absorbance) (DOI=10.5897/IJBMBR2013.0154); 22.9 hours (NCI-DTP); ~28 hours (CLS); ~40 hours (DSMZ). Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger). Omics: Acetylation analysis by proteomics. Omics: Array-based CGH. Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep membrane proteome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Fluorescence phenotype profiling. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K9ac ChIP-seq epigenome analysis. Omics: lncRNA expression profiling. Omics: Metabolome analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: Proteome analysis by 2D-DE/MS. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. Omics: Virome analysis using proteomics. Misspelling: A594; In PubMed=18227028. Misspelling: A59; In PubMed=16354588. | PubMed=4357758; DOI=10.1093/jnci/51.5.1417 Giard D.J., Aaronson S.A., Todaro G.J., Arnstein P., Kersey J.H., Dosik H., Parks W.P. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J. Natl. Cancer Inst. 51:1417-1423(1973) PubMed=175022; DOI=10.1002/ijc.2910170110 Lieber M.M., Smith B.T., Szakal A., Nelson-Rees W.A., Todaro G.J. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 17:62-70(1976) PubMed=327080; DOI=10.1093/jnci/59.1.221 Fogh J., Fogh J.M., Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59:221-226(1977) PubMed=833871; DOI=10.1093/jnci/58.2.209 Fogh J., Wright W.C., Loveless J.D. Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J. Natl. Cancer Inst. 58:209-214(1977) PubMed=842942; DOI=10.1164/arrd.1977.115.2.285 Smith B.T. Cell line A549: a model system for the study of alveolar type II cell function. Am. Rev. Respir. Dis. 115:285-293(1977) PubMed=924690; DOI=10.1002/ijc.2910200505 Kerbel R.S., Pross H.F., Leibovitz A. Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors. Int. J. Cancer 20:673-679(1977) PubMed=375235; DOI=10.1073/pnas.76.3.1288 Sherwin S.A., Sliski A.H., Todaro G.J. Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces. Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979) PubMed=6256643; DOI=10.1038/288724a0 Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature 288:724-727(1980) PubMed=22282976; DOI=10.1093/carcin/1.1.21 Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Mattern M.R. Human tumor cell strains defective in the repair of alkylation damage. Carcinogenesis 1:21-32(1980) PubMed=6935474; DOI=10.1093/jnci/66.2.239 Wright W.C., Daniels W.P., Fogh J. Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis. J. Natl. Cancer Inst. 66:239-247(1981) PubMed=7459858 Rousset M., Zweibaum A., Fogh J. Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins. Cancer Res. 41:1165-1170(1981) PubMed=6954533; DOI=10.1073/pnas.79.7.2194 Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., Aaronson S.A., Wong-Staal F. Differential expression of the amv gene in human hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982) PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) PubMed=6825208; DOI=10.1093/carcin/4.2.199 Yarosh D.B., Foote R.S., Mitra S., Day R.S. III Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains. Carcinogenesis 4:199-205(1983) PubMed=6148444; DOI=10.1093/jnci/73.4.801 Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H., Mitchell J.B. Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines. J. Natl. Cancer Inst. 73:801-807(1984) PubMed=6500159; DOI=10.1159/000163283 Gershwin M.E., Lentz D., Owens R.B. Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice. Exp. Cell Biol. 52:361-370(1984) PubMed=3518877; DOI=10.3109/07357908609038260 Fogh J. Human tumor lines for cancer research. Cancer Invest. 4:157-184(1986) PubMed=3940644 Brower M., Carney D.N., Oie H.K., Gazdar A.F., Minna J.D. Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Cancer Res. 46:798-806(1986) PubMed=3945555; DOI=10.1093/nar/14.2.843 Valenzuela D.M., Groffen J. Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene. Nucleic Acids Res. 14:843-852(1986) PubMed=3129183 Hubbard W.C., Alley M.C., McLemore T.L., Boyd M.R. Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas. Cancer Res. 48:2674-2677(1988) PubMed=3335022 Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589-601(1988) PubMed=3413074; DOI=10.1073/pnas.85.16.6042 Pereira-Smith O.M., Smith J.R. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988) PubMed=2388294; DOI=10.1093/jnci/82.17.1420 McLemore T.L., Litterst C.L., Coudert B.P., Liu M.C., Hubbard W.C., Adelberg S., Czerwinski M.J., McMahon N.A., Eggleston J.C., Boyd M.R. Metabolic activation of 4-ipomeanol in human lung, primary pulmonary carcinomas, and established human pulmonary carcinoma cell lines. J. Natl. Cancer Inst. 82:1420-1426(1990) PubMed=1855224 Lehman T.A., Bennett W.P., Metcalf R.A., Welsh J.A., Ecker J., Modali R.V., Ullrich S., Romano J.W., Appella E., Testa J.R., Gerwin B.I., Harris C.C. p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res. 51:4090-4096(1991) PubMed=2041050; DOI=10.1093/jnci/83.11.757 Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K., Vistica D.T., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst. 83:757-766(1991) PubMed=8286010 Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T. Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines. Anticancer Drug Des. 8:417-428(1993) PubMed=7736387; DOI=10.1002/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q Campling B.G., Sarda I.R., Baer K.A., Pang S.C., Baker H.M., Lofters W.S., Flynn T.G. Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer. Cancer 75:2442-2451(1995) PubMed=8626706; DOI=10.1074/jbc.271.19.11477 Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M., Grimley C., Battey J., Mulshine J.L., Cuttitta F. Insulin-like growth factor expression in human cancer cell lines. J. Biol. Chem. 271:11477-11483(1996) PubMed=9023415; DOI=10.1006/cimm.1996.1062 Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K. HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer. Cell. Immunol. 175:101-110(1997) PubMed=9178645; DOI=10.1006/cimm.1997.1108 Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M., Itoh K. CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma. Cell. Immunol. 177:176-181(1997) PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog. 19:243-253(1997) PubMed=9538136; DOI=10.3892/ijo.12.5.1103 Takaki T., Hiraki A., Uenaka A., Gomi S., Itoh K., Udono H., Shibuya A., Tsuji T., Sekiguchi S., Nakayama E. Variable expression on lung cancer cell lines of HLA-A2-binding MAGE- 3 peptide recognized by cytotoxic T lymphocytes. Int. J. Oncol. 12:1103-1109(1998) PubMed=9636188; DOI=10.1073/pnas.95.13.7556 Kaplan D.H., Shankaran V., Dighe A.S., Stockert E., Aguet M., Old L.J., Schreiber R.D. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 95:7556-7561(1998) PubMed=9649128; DOI=10.1038/bjc.1998.361 Yi S., Chen J.-R., Viallet J., Schwall R.H., Nakamura T., Tsao M.-S. Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines. Br. J. Cancer 77:2162-2170(1998) PubMed=10358721; DOI=10.18926/AMO/31626 Matsushita A., Tabata M., Ueoka H., Kiura K., Shibayama T., Aoe K., Kohara H., Harada M. Establishment of a drug sensitivity panel using human lung cancer cell lines. Acta Med. Okayama 53:67-75(1999) PubMed=10700174; DOI=10.1038/73432 Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V., Jeffrey S.S., van de Rijn M., Waltham M., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O. Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet. 24:227-235(2000) PubMed=11005564; DOI=10.1038/sj.neo.7900094 Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J. Mutation and expression of the DCC gene in human lung cancer. Neoplasia 2:300-305(2000) PubMed=11369051; DOI=10.1016/S0165-4608(00)00363-0 Luk C., Tsao M.-S., Bayani J., Shepherd F., Squire J.A. Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. Cancer Genet. Cytogenet. 125:87-99(2001) PubMed=11958134 Zhan X.-Q., Guan Y.-J., Li C., Chen Z.-C., Xie J.-Y., Chen P., Liang S.-P. Differential proteomic analysis of human lung adenocarcinoma cell line A-549 and of normal cell line HBE. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:50-56(2002) PubMed=12661003; DOI=10.1002/gcc.10196 Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.-F., Schlag P.M., Scherneck S. Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. Genes Chromosomes Cancer 37:29-35(2003) PubMed=12794755; DOI=10.1002/ijc.11184 Endoh H., Yatabe Y., Shimizu S., Tajima K., Kuwano H., Takahashi T., Mitsudomi T. RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. Int. J. Cancer 106:45-51(2003) PubMed=14581340 Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J. TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin. Cancer Res. 9:4705-4713(2003) PubMed=15746151; DOI=10.1093/hmg/ddi092 Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I. Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Hum. Mol. Genet. 14:997-1007(2005) PubMed=15748285; DOI=10.1186/1479-5876-3-11 Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. III, Stroncek D., Marincola F.M. HLA class I and II genotype of the NCI-60 cell lines. J. Transl. Med. 3:11-11(2005) PubMed=15900046; DOI=10.1093/jnci/dji133 Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J. Natl. Cancer Inst. 97:765-777(2005) PubMed=15999539 Matsumura T., Takigawa N., Kiura K., Shibayama T., Chikamori M., Tabata M., Ueoka H., Tanimoto M. Determinants of cisplatin and irinotecan activities in human lung adenocarcinoma cells: evidence of cisplatin accumulation and topoisomerase I activity. In Vivo 19:717-721(2005) PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433 Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Mironenko T., Parker A., Perry J., Raine K., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol. Cancer Ther. 5:2606-2612(2006) PubMed=17331233; DOI=10.1186/1471-2164-8-62 Nymark P., Lindholm P.M., Korpela M.V., Lahti L., Ruosaari S., Kaski S., Hollmen J., Anttila S., Kinnula V.L., Knuutila S. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines. BMC Genomics 8:62-62(2007) PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339 Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K. Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer Res. 67:2046-2053(2007) PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y., Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K., Yasumoto K. Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro. Cancer Sci. 98:1048-1054(2007) PubMed=18083107; DOI=10.1016/j.cell.2007.11.025 Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-1203(2007) PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921 Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N. DNA fingerprinting of the NCI-60 cell line panel. Mol. Cancer Ther. 8:713-724(2009) PubMed=19472407; DOI=10.1002/humu.21028 Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M. A gene-alteration profile of human lung cancer cell lines. Hum. Mutat. 30:1199-1206(2009) PubMed=19608861; DOI=10.1126/science.1175371 Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834-840(2009) PubMed=19657000 Rubporn A., Srisomsap C., Subhasitanont P., Chokchaichamnankit D., Chiablaem K., Svasti J., Sangvanich P. Comparative proteomic analysis of lung cancer cell line and lung fibroblast cell line. Cancer Genomics Proteomics 6:229-237(2009) PubMed=20164919; DOI=10.1038/nature08768 Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R. Signatures of mutation and selection in the cancer genome. Nature 463:893-898(2010) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=20545000; DOI=10.3724/SP.J.1141.2010.02113 Peng K.-J., Wang J.-H., Su W.-T., Wang X.-C., Yang F.-T., Nie W.-H. Characterization of two human lung adenocarcinoma cell lines by reciprocal chromosome painting. Dong Wu Xue Yan Jiu 31:113-121(2010) PubMed=21060948; DOI=10.1039/c0mb00055h Yu G., Xiao C.-L., Lu C.-H., Jia H.-T., Ge F., Wang W., Yin X.-F., Jia H.-L., He J.-X., He Q.-Y. Phosphoproteome profile of human lung cancer cell line A549. Mol. Biosyst. 7:472-479(2011) PubMed=22068913; DOI=10.1073/pnas.1111840108 Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J., Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V., Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R., Ambudkar S.V., Gottesman M.M. Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011) PubMed=22278370; DOI=10.1074/mcp.M111.014050 Geiger T., Wehner A., Schaab C., Cox J., Mann M. Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012) PubMed=22313637; DOI=10.4161/cbt.19238 Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E. Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity. Cancer Biol. Ther. 13:369-378(2012) PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017 Kong D., Yamori T. JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs. Bioorg. Med. Chem. 20:1947-1951(2012) PubMed=22384151; DOI=10.1371/journal.pone.0032096 Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H., Yoon C.N., Chang Y.-T. Identification of cancer cell-line origins using fluorescence image-based phenomic screening. PLoS ONE 7:E32096-E32096(2012) PubMed=22460905; DOI=10.1038/nature11003 Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483:603-607(2012) PubMed=22481983; DOI=10.2174/1874091X01206010016 Chauhan V., Howland M., Wilkins R. Effects of alpha-particle radiation on microRNA responses in human cell-lines. Open Biochem. J. 6:16-22(2012) PubMed=22576795; DOI=10.3892/or.2012.1763 Ashinuma H., Takiguchi Y., Kitazono S., Kitazono-Saitoh M., Kitamura A., Chiba T., Tada Y., Kurosu K., Sakaida E., Sekine I., Tanabe N., Iwama A., Yokosuka O., Tatsumi K. Antiproliferative action of metformin in human lung cancer cell lines. Oncol. Rep. 28:8-14(2012) PubMed=22628656; DOI=10.1126/science.1218595 Jain M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza A.L., Kafri R., Kirschner M.W., Clish C.B., Mootha V.K. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336:1040-1044(2012) PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112 Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov. 2:798-811(2012) DOI=10.5897/IJBMBR2013.0154 Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A., Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L. Cell growth curves for different cell lines and their relationship with biological activities. Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013) PubMed=23325432; DOI=10.1101/gr.147942.112 Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M. Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res. 23:555-567(2013) PubMed=23404217; DOI=10.1007/s11626-013-9581-9 Chang D., Xu H.-W., Guo Y.-H., Jiang X., Liu Y., Li K.-L., Pan C.-X., Yuan M., Wang J.-F., Li T.-Z., Liu C.-T. Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line. In Vitro Cell. Dev. Biol. Anim. 49:170-177(2013) PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342 Abaan O.D., Polley E.C., Davis S.R., Zhu Y.J., Bilke S., Walker R.L., Pineda M., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 73:4372-4382(2013) PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018 Moghaddas Gholami A., Hahne H., Wu Z., Auer F.J., Meng C., Wilhelm M., Kuster B. Global proteome analysis of the NCI-60 cell line panel. Cell Rep. 4:609-620(2013) PubMed=24135919; DOI=10.1038/ncomms3617 Balbin O.A., Prensner J.R., Sahu A., Yocum A., Shankar S., Malik R., Fermin D., Dhanasekaran S.M., Chandler B., Thomas D., Beer D.G., Cao X., Nesvizhskii A.I., Chinnaiyan A.M. Reconstructing targetable pathways in lung cancer by integrating diverse omics data. Nat. Commun. 4:2617-2617(2013) PubMed=24279929; DOI=10.1186/2049-3002-1-20 Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A. The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer Metab. 1:20-20(2013) PubMed=24618588; DOI=10.1371/journal.pone.0091433 Chernobrovkin A.L., Zubarev R.A. Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins. PLoS ONE 9:E91433-E91433(2014) PubMed=24670534; DOI=10.1371/journal.pone.0092047 Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C. High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner. PLoS ONE 9:E92047-E92047(2014) PubMed=25120651; DOI=10.3892/ol.2014.2234 Suzuki M., Ikeda K., Shiraishi K., Eguchi A., Mori T., Yoshimoto K., Shibata H., Ito T., Baba Y., Baba H. Aberrant methylation and silencing of IRF8 expression in non-small cell lung cancer. Oncol. Lett. 8:1025-1030(2014) PubMed=25475639; DOI=10.5731/pdajpst.2014.01027 Shabram P., Kolman J.L. Evaluation of A549 as a new vaccine cell substrate: digging deeper with massively parallel sequencing. PDA J. Pharm. Sci. Technol. 68:639-650(2014) PubMed=25960936; DOI=10.4161/21624011.2014.954893 Boegel S., Lower M., Bukur T., Sahin U., Castle J.C. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. OncoImmunology 3:E954893-E954893(2014) PubMed=25984343; DOI=10.1038/sdata.2014.35 Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci. Data 1:140035-140035(2014) PubMed=25485619; DOI=10.1038/nbt.3080 Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 33:306-312(2015) PubMed=26202522; DOI=10.1021/acs.jproteome.5b00477 Kitata R.B., Dimayacyac-Esleta B.R., Choong W.-K., Tsai C.-F., Lin T.-D., Tsou C.-C., Weng S.-H., Chen Y.-J., Yang P.-C., Arco S.D., Nesvizhskii A.I., Sung T.-Y., Chen Y.-J. Mining missing membrane proteins by high-pH reverse-phase stagetip fractionation and multiple reaction monitoring mass spectrometry. J. Proteome Res. 14:3658-3669(2015) PubMed=26554430; DOI=10.1021/acs.analchem.5b03639 Dimayacyac-Esleta B.R., Tsai C.-F., Kitata R.B., Lin P.-Y., Choong W.-K., Lin T.-D., Wang Y.-T., Weng S.-H., Yang P.-C., Arco S.D., Sung T.-Y., Chen Y.-J. Rapid high-pH reverse phase stagetip for sensitive small-scale membrane proteomic profiling. Anal. Chem. 87:12016-12023(2015) PubMed=27377824; DOI=10.1038/sdata.2016.52 Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J. Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR. Sci. Data 3:160052-160052(2016) PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J. A landscape of pharmacogenomic interactions in cancer. Cell 166:740-754(2016) PubMed=27807467; DOI=10.1186/s13100-016-0078-4 Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H. A map of mobile DNA insertions in the NCI-60 human cancer cell panel. Mob. DNA 7:20-20(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=28601559; DOI=10.1016/j.cels.2017.05.009 Bekker-Jensen D.B., Kelstrup C.D., Batth T.S., Larsen S.C., Haldrup C., Bramsen J.B., Sorensen K.D., Hoyer S., Orntoft T.F., Andersen C.L., Nielsen M.L., Olsen J.V. An optimized shotgun strategy for the rapid generation of comprehensive human proteomes. Cell Syst. 4:587-599.e4(2017) PubMed=28746345; DOI=10.1371/journal.pone.0181081 Sarin N., Engel F., Kalayda G.V., Mannewitz M., Cinatl J. Jr., Rothweiler F., Michaelis M., Saafan H., Ritter C.A., Jaehde U., Frotschl R. Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. PLoS ONE 12:E0181081-E0181081(2017) PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051 Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D., Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., McCormick F. Differential effector engagement by oncogenic KRAS. Cell Rep. 22:1889-1902(2018) PubMed=29457907; DOI=10.1021/acs.jproteome.7b00782 Tomin T., Fritz K., Gindlhuber J., Waldherr L., Pucher B., Thallinger G.G., Nomura D.K., Schittmayer M., Birner-Gruenberger R. Deletion of adipose triglyceride lipase links triacylglycerol accumulation to a more-aggressive phenotype in A549 lung carcinoma cells. J. Proteome Res. 17:1415-1425(2018) PubMed=29681454; DOI=10.1016/j.cell.2018.03.028 McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A., Gibbs R.A., Hwang T.-H., Heymach J.V., Wistuba I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., Deberardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A. Chemistry-first approach for nomination of personalized treatment in lung cancer. Cell 173:864-878.e29(2018) PubMed=29718670; DOI=10.1021/acs.jproteome.8b00165 Clark D.J., Hu Y., Bocik W., Chen L., Schnaubelt M., Roberts R., Shah P., Whiteley G., Zhang H. Evaluation of NCI-7 cell line panel as a reference material for clinical proteomics. J. Proteome Res. 17:2205-2215(2018) PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019) PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019) PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P. Quantitative proteomics of the Cancer Cell Line Encyclopedia. Cell 180:387-402.e16(2020) | https://en.wikipedia.org/wiki/A549_cell |
AGE1.CR | CVCL_S509 | Áno | CVCL_S508 (AGE1.CR.pIX) | kačica pižmová | Cairina moschata | zvieracia | etická | CR; CR.HS | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B] | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Serum/protein free medium cell line. From: ProBioGen AG; Berlin; Germany. Doubling time: 23 hours (PubMed=19531390). Transformant: NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B]. | PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066 Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V. An avian cell line designed for production of highly attenuated viruses. Vaccine 27:748-756(2009) PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083 Lohr V., Rath A., Genzel Y., Jordan I., Sandig V., Reichl U. New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27:4975-4982(2009) CLPUB00344 Ogorek C. Characterization of the N-glycosylation profile of the new avian cell line AGE1.CR and the modification of fucosylation. Thesis PhD (2012), Freien Universitat Berlin, Germany PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=26814192; DOI=10.1080/03079457.2016.1138280 Jordan I., John K., Howing K., Lohr V., Penzes Z., Gubucz-Sombor E., Fu Y., Gao P., Harder T., Zadori Z., Sandig V. Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccines. Avian Pathol. 45:137-155(2016) | https://www.probiogen.de/virus-production-cell-lines.html |
AGE1.CR.pIX | CVCL_S508 | CVCL_S509 (AGE1.CR) | / | kačica pižmová | Cairina moschata | zvieracia | etická | CR.pIX; CR.MCX | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B] | UniProtKB; P03281; Adenovirus 5 pIX | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Bird cell line. Group: Serum/protein free medium cell line. From: ProBioGen AG; Berlin; Germany. Characteristics: Permissive for a wide spectrum of animal and human viruses including influenza (broad strain spectrum), rabies virus, Newcastle disease virus (NDV), duck and goose parvovirus, egg drop syndrome virus (EDS), infectious bursal disease virus (IBDV), turkey rhinotracheitis virus (TRT), Marek disease virus (MDV), vesicular stomatitis virus (VSV) and herpesvirus of turkey (HVT) (ProBioGen). Doubling time: 35 hours (PubMed=19531390). | PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066 Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V. An avian cell line designed for production of highly attenuated viruses. Vaccine 27:748-756(2009) PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083 Lohr V., Rath A., Genzel Y., Jordan I., Sandig V., Reichl U. New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27:4975-4982(2009) CLPUB00344 Ogorek C. Characterization of the N-glycosylation profile of the new avian cell line AGE1.CR and the modification of fucosylation. Thesis PhD (2012), Freien Universitat Berlin, Germany PubMed=25077436; DOI=10.1186/1472-6750-14-72 Lohr V., Hadicke O., Genzel Y., Jordan I., Buntemeyer H., Klamt S., Reichl U. The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis. BMC Biotechnol. 14:72-72(2014) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=26814192; DOI=10.1080/03079457.2016.1138280 Jordan I., John K., Howing K., Lohr V., Penzes Z., Gubucz-Sombor E., Fu Y., Gao P., Harder T., Zadori Z., Sandig V. Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccines. Avian Pathol. 45:137-155(2016) | https://www.probiogen.de/virus-production-cell-lines.html |
AGE1.CS | CVCL_S510 | / | / | kačica pižmová | Cairina moschata | zvieracia | etická | CS | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B]. | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Bird cell line.From: ProBioGen AG; Berlin; Germany.Transformant: NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B]. | PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066 Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V. An avian cell line designed for production of highly attenuated viruses. Vaccine 27:748-756(2009) | https://www.probiogen.de/virus-production-cell-lines.html |
BA3 | CVCL_HF39 | / | / | kura bankivská | Gallus gallus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Indukované pluripotentné kmeňové bunky | / | neurčené | embryonálne | 11 fetálnych dní | Group: Bird cell line. Doubling time: 21 hours (PubMed=26586283); 24-36 hours (Kerafast). | PubMed=26586283; DOI=10.1016/j.biologicals.2015.09.002 Shittu I., Zhu Z.-Y., Lu Y.-Q., Hutcheson J.M., Stice S.L., West F.D., Donadeu M., Dungu B., Fadly A.M., Zavala G., Ferguson-Noel N., Afonso C.L. Development, characterization and optimization of a new suspension chicken-induced pluripotent cell line for the production of Newcastle disease vaccine. Biologicals 44:24-32(2016) | / |
BHK-21 | CVCL_1914 | Áno | CVCL_1915 (BHK-21 clone 13) CVCL_HB78 (BHK-21/WI-2) CVCL_W329 (BHK-HVJ) | škrečok zlatý | Mesocricetus auratus | zvieracia | etická | BHK 21; BHK21; Baby Hamster Kidney-21; Baby Hamster Kidney 21; Baby Hamster Kidney from litter No. 21; BHK | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | mužské | dospelé | 1 deň | Group: Space-flown cell line (cellonaut). Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Doubling time: 12 hours (PubMed=14207308). Miscellaneous: Not distributed parent cell line. | PubMed=14207308; DOI=10.1038/2031355a0 Stoker M., MacPherson I.A. Syrian hamster fibroblast cell line BHK21 and its derivatives. Nature 203:1355-1357(1964) PubMed=1263417 Sushkov F.V., Portugalov V.V., Rudneva S.V., Bobkova N.N., Iordanishvili E.K., Izupak E.A. Results of mammalian cell culture exposure on artificial earth satellites. Kosm. Biol. Aviakosm. Med. 10:58-63(1976) PubMed=6298990; DOI=10.1016/0378-1135(82)90056-6 McPhee D.A., Parsonson I.M., Della-Porta A.J. Comparative studies on the growth of Australian bluetongue virus serotypes in continuous cell lines and embryonated chicken eggs. Vet. Microbiol. 7:401-410(1982) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) | https://en.wikipedia.org/wiki/Baby_hamster_kidney_cell |
BTI-Tn-5B1-4 | CVCL_C190 | CVCL_Z410 (BTI-Tn-5B1-28) | CVCL_Z252 (BTI-Tnao38) CVCL_Z094 (H5CL-B) CVCL_Z095 (H5CL-F)CVCL_RW20 (Hi-5 Rix4446) CVCL_UF19 (High5-ht33) CVCL_UF20 (High5-ht35)CVCL_Z431 (Tn-4h) CVCL_RY32 (Tni-FNL) CVCL_RT23 (Tnms42) | kapustník | Trichoplusia ni | zvieracia | etická | BTI-TN-5B1-4; BTI-TN5B1-4; BTI-Tn5B14; BTI-Tn 5B1-4; Tn-5B1-4; Tn 5B1-4; Tn5 B1-4; Tn5B1-4; TN5B14; TnH5; High Five; High 5; High-5; High5; Hi-five; Hi-5; Hi5; Tn-5 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Insect cell line. Group: Recombinant protein production insect cell line. Characteristics: Infected with the alphanodavirus TnCLV. Doubling time: 26 hours (PubMed=21667340); 34 +- 1 hours (in static culture), 27 +- 2 hours (in suspension culture) (PubMed=10585188). Omics: Genome sequenced. | PubMed=1369220; DOI=10.1021/bp00017a003 Wickham T.J., Davis T., Granados R.R., Shuler M.L., Wood H.A. Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnol. Prog. 8:391-396(1992) PubMed=8314732; DOI=10.1007/BF02633986 Davis T.R., Wickham T.J., McKenna K.A., Granados R.R., Shuler M.L., Wood H.A. Comparative recombinant protein production of eight insect cell lines. In Vitro Cell. Dev. Biol. Anim. 29:388-390(1993) DOI=10.1016/S0022-2011(94)90400-6 Granados R.R., Li G.-X., Derksen A.C.G., McKenna K.A. A new insect cell line from Trichoplusia ni (BTI-Tn-5B1-4) susceptible to Trichoplusia ni single enveloped nuclear polyhedrosis virus. J. Invertebr. Pathol. 64:260-266(1994) Patent=US5300435 Granados R.R. Trichoplusia ni cell line which supports replication of other baculoviruses. Patent number US5300435, 05-Apr-1994 PubMed=10358729 Yanase T., Yasunaga C., Kawarabata T. Replication of Spodoptera exigua nucleopolyhedrovirus in permissive and non-permissive lepidopteran cell lines. Acta Virol. 42:293-298(1998) PubMed=10397817; DOI=10.1002/(SICI)1097-0290(19990605)63:5<612::AID-BIT11>3.0.CO;2-C Saarinen M.A., Troutner K.A., Gladden S.G., Mitchell-Logean C.M., Murhammer D.W. Recombinant protein synthesis in Trichoplusia ni BTI-Tn-5B1-4 insect cell aggregates. Biotechnol. Bioeng. 63:612-617(1999) PubMed=10585188; DOI=10.1021/bp990119f Keith M.B., Farrell P.J., Iatrou K., Behie L.A. Screening of transformed insect cell lines for recombinant protein production. Biotechnol. Prog. 15:1046-1052(1999) Patent=US7179648 Granados R.R., Li G.-X. Clonal cell lines derived from BTI-TN-5B1-4. Patent number US7179648, 20-Feb-2007 PubMed=17686877; DOI=10.1128/JVI.00807-07 Li T.-C., Scotti P.D., Miyamura T., Takeda N. Latent infection of a new alphanodavirus in an insect cell line. J. Virol. 81:10890-10896(2007) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=20300881; DOI=10.1007/s12033-010-9268-3 Krammer F., Schinko T., Palmberger D., Tauer C., Messner P., Grabherr R. Trichoplusia ni cells (High Five) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vaccines. Mol. Biotechnol. 45:226-234(2010) PubMed=21667340; DOI=10.1007/s12250-011-3177-x Wu Y.-L., Jiang L., Hashimoto Y., Granados R.R., Li G.-X. Establishment, growth kinetics, and susceptibility to AcMNPV of heat tolerant lepidopteran cell lines. Virol. Sin. 26:198-205(2011) PubMed=24375231; DOI=10.1007/s10529-013-1429-6 Wilde M., Klausberger M., Palmberger D., Ernst W., Grabherr R. Tnao38, high five and Sf9 -- evaluation of host-virus interactions in three different insect cell lines: baculovirus production and recombinant protein expression. Biotechnol. Lett. 36:743-749(2014) PubMed=29133148; DOI=10.1016/j.pep.2017.11.002 Geisler C., Jarvis D.L. Adventitious viruses in insect cell lines used for recombinant protein expression. Protein Expr. Purif. 144:25-32(2017) PubMed=29376823; DOI=10.7554/eLife.31628 Fu Y., Yang Y., Zhang H., Farley G., Wang J., Quarles K.A., Weng Z., Zamore P.D. The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology. eLife 7:E31628-E31628(2018) PubMed=30449074; DOI=10.1111/1755-0998.12966 Chen W.-B., Yang X.-W., Tetreau G., Song X.-Z., Coutu C., Hegedus D., Blissard G.W., Fei Z.-J., Wang P. A high-quality chromosome-level genome assembly of a generalist herbivore, Trichoplusia ni. Mol. Ecol. Resour. 19:485-496(2019) | https://en.wikipedia.org/wiki/High_Five_cells |
CCRC-1 | CVCL_LK64 | / | / | človek | Homo sapiens | ľudská | etická | Cell Collection and Research Center-1 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | kmeňové bunky | neurčené | dospelé | / | Characteristics: Susceptible to infection by a wide spectrum of viruses. Doubling time: 30.8 +- 6.2 hours (at 10th passage), 36.5 +- 4.0 hours (at 15th passage), 42.8 +- 2.3 hours (at 20th passage), 41.8 +- 4.3 hours (at 25th passage), 42.4 +- 3.4 hours (at 30th passage) (DOI=10.1038/s41598-017-11997-1). Kmeňové bunky z mezenchýmu (rôsolovitého embryonálneho väziva) z ľudského pupočníka (chorda umbilicalis) | PubMed=28970485; DOI=10.1038/s41598-017-11997-1 Chen P., Zhang K.-H., Na T., Wang L., Yin W.-D., Yuan B.-Z., Wang J.-Z. The hUC-MSCs cell line CCRC-1 represents a novel, safe and high-yielding HDCs for the production of human viral vaccines. Sci. Rep. 7:12484-12484(2017) | / |
COS-1-pA104R | CVCL_ZW94 | CVCL_0223 (COS-1) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 1891767; Simian virus 40 (SV40) [pSV6-1] | UniProtKB; P00552; Transposon Tn5 neo; UniProtKB; P68742; African swine fever virus (AFSV) isolate Ba71V pA104R. | Transformované bunkové línie | obličkové | mužské | dospelé | / | Group: Non-human primate cell line. | PubMed=31323824; DOI=10.3390/vaccines7030068 Freitas F.B., Simoes M., Frouco G., Martins C., Ferreira F. Towards the generation of an ASFV-pA104R DISC mutant and a complementary cell line -- a potential methodology for the production of a vaccine candidate. Vaccines (Basel). 7:68.1-68.16(2019) | / |
CRFK | CVCL_2426 | CVCL_DB45 (FCK) | CVCL_W183 (CCC3a subline 8C) CVCL_X693 (CRFK/FIV-AZR-1) CVCL_WL54 (Teth-CRFK) | mačka domáca | Felis silvestris catus | zvieracia | etická | CrFK; Crfk; Crandell Reese Feline Kidney; Crandell Feline Kidney; CCC; Crandell's Cat Cell | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | 3 mesiace | Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Biotechnology: Widely used to manufacture vaccines for parvoviruses such as feline panleukopenia virus (FPLV) and canine parvoviruses (CPVs). Characteristics: Persistently infected by feline endogenous virus RD-114. | PubMed=4130570; DOI=10.1007/BF02618435 Crandell R.A., Fabricant C.G., Nelson-Rees W.A. Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK). In Vitro 9:176-185(1973) PubMed=1313703; DOI=10.1292/jvms.54.173 Miyazawa T., Toyosaki T., Tomonaga K., Norimine J., Ohno K., Hasegawa A., Kai C., Mikami T. Further characterization of a feline T-lymphoblastoid cell line (MYA-1 cells) highly sensitive for feline immunodeficiency virus. J. Vet. Med. Sci. 54:173-175(1992) PubMed=9696876; DOI=10.1128/JVI.72.9.7685-7687.1998 Baumann J.G., Gunzburg W.H., Salmons B. CrFK feline kidney cells produce an RD114-like endogenous virus that can package murine leukemia virus-based vectors. J. Virol. 72:7685-7687(1998) PubMed=20631117; DOI=10.1128/JCM.00992-10 Yoshikawa R., Sato E., Igarashi T., Miyazawa T. Characterization of RD-114 virus isolated from a commercial canine vaccine manufactured using CRFK cells. J. Clin. Microbiol. 48:3366-3369(2010) PubMed=21029758; DOI=10.1016/j.virusres.2010.10.020 Okada M., Yoshikawa R., Shojima T., Baba K., Miyazawa T. Susceptibility and production of a feline endogenous retrovirus (RD-114 virus) in various feline cell lines. Virus Res. 155:268-273(2011) PubMed=23585909; DOI=10.1371/journal.pone.0061530 Fukuma A., Yoshikawa R., Miyazawa T., Yasuda J. A new approach to establish a cell line with reduced risk of endogenous retroviruses. PLoS ONE 8:E61530-E61530(2013) | http://www.rccc.cytspb.rssi.ru/ecellbank/animal/acrfk.htm |
DBS-FCL-1 | CVCL_4158 | / | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | DBS-FCL1; Division of Biologics Standards-Fetal Cercopithecus Lung-1 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | mužské | embryonálne | 135 fetálnych dní | Group: Non-human primate cell line. | PubMed=4633070; DOI=10.1007/BF02619057 Wallace R.E., Vasington P.J., Petricciani J.C., Hopps H.E., Lorenz D.E., Kadanka Z. Development and characterization of cell lines from subhuman primates. In Vitro 8:333-341(1973) PubMed=4203458 Petricciani J.C., Wallace R.E., McCoy D.W. A comparison of three in vivo assays for cell tumorigenicity. Cancer Res. 34:105-108(1974) Patent=US4040905 Hopps H.E., Lorenz D.E., Petricciani J.C., Vasington P.J., Wallace R.E. Sub-human primate diploid cell lines as substrates for virus vaccine production. Patent number US4040905, 09-Aug-1977 PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) | / |
DBS-FCL-2 | CVCL_4159 | / | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | DBS-FCL2; FCL-2; Division of Biologics Standards-Fetal Cercopithecus Lung-2 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | mužské | embryonálne | 141 fetálnych dní | Group: Non-human primate cell line. Characteristics: Senesces at ~12 PDL. | PubMed=4633070; DOI=10.1007/BF02619057 Wallace R.E., Vasington P.J., Petricciani J.C., Hopps H.E., Lorenz D.E., Kadanka Z. Development and characterization of cell lines from subhuman primates. In Vitro 8:333-341(1973) Patent=US4040905 Hopps H.E., Lorenz D.E., Petricciani J.C., Vasington P.J., Wallace R.E. Sub-human primate diploid cell lines as substrates for virus vaccine production. Patent number US4040905, 09-Aug-1977 PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) | / |
DBS-FRhL-2 | CVCL_4160 | / | / | makak rhesus | Macaca mulatta | zvieracia | etická | DBS-FRHL-2; DBSFRhL-2; DBSFRHL-2; DBSFRhL2; FRhL-2; FrHL-2; FrhL2; Division of Biologics Standards-Fetal Rhesus Lung-2 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | mužské | embryonálne | / | Group: Non-human primate cell line. Biotechnology: Was used from 1997 to 1999 for the production of the rhesus rotavirus vaccine-tetravalent (RRV-TV) by Wyeth Laboratories (Trade Name: RotaShield). Characteristics: Senesces at ~74 PDL. Discontinued: IZSLER; BS CL 215; probable. | PubMed=4348695; DOI=10.1007/BF02619056 Wallace R.E., Vasington P.J., Petricciani J.C., Hopps H.E., Lorenz D.E., Kadanka Z. Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production. In Vitro 8:323-332(1973) PubMed=4203458 Petricciani J.C., Wallace R.E., McCoy D.W. A comparison of three in vivo assays for cell tumorigenicity. Cancer Res. 34:105-108(1974) Patent=US4040905 Hopps H.E., Lorenz D.E., Petricciani J.C., Vasington P.J., Wallace R.E. Sub-human primate diploid cell lines as substrates for virus vaccine production. Patent number US4040905, 09-Aug-1977 PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) | / |
DEC+99 | CVCL_JF07 | / | / | kačica divá | Anas platyrhynchos / boschas | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | 14 fetálnych dní | Group: Bird cell line. Doubling time: ~36 hours (CelloPub=CLPUB00393). | CLPUB00393: Ivanov I.G., Kril A.I.: Establishment and characterization of a permanent duck embryo cell line. Exp. Pathol. Parasitol. 4:41-44(2000); CLPUB00394: Todorova K., Ivanov I., Georgieva A., Lazarova S., Milcheva R., Dimitrov P., Dimitrov R., Russev R.: Fumonisin B1 cytotoxicity and subcellular localization in duck embryo cell line DEC 99. C. R. Acad. Bulg. Sci. 68:617-622(2015) | / |
DuckCelt-T17 | CVCL_JF18 | Áno | CVCL_JF17 (T17-17703A) CVCL_JF15 (T17-17703B) CVCL_JF16 (T17-17703B2) | kačica pižmová | Cairina moschata | zvieracia | etická | DuckCeltTM-T17; T17 | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A] | UniProtKB; B7S5K9; Cairina moschata TERT | Telomerázou imortalizované bunkové línie | / | neurčené | / | / | Group: Bird cell line. Group: Serum/protein free medium cell line. From: Transgene SA; France. | CLPUB00392 Petiot E., Proust A., Traversier A., Rosa-Calatrava M., Balloul J.-M. Novel avian DuckCeltTM-T17 cell line for production of viral vaccines: application to influenza viruses production. (In) Vaccine Technology VI; Palomares L., Cox M., Mukhopadhyay T., Garcon N. (eds.); pp.56-56; ECI Symposium Series; New York (2016) PubMed=28571695; DOI=10.1016/j.vaccine.2017.03.102 Petiot E., Proust A., Traversier A., Durous L., Dappozze F., Gras M., Guillard C., Balloul J.-M., Rosa-Calatrava M. Influenza viruses production: evaluation of a novel avian cell line DuckCelt(R)-T17. Vaccine 36:3101-3111(2018) | / |
EB66 | CVCL_G703 | / | / | kačica divá | Anas platyrhynchos / boschas | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Embryonálne kmeňové bunky | / | mužské | embryonálne | blastocysta | Group: Bird cell line. Group: Serum/protein free medium cell line. From: Valneva SE; France. | PubMed=20562528 Olivier S., Jacoby M., Brillon C., Bouletreau S., Mollet T., Nerriere O., Angel A., Danet S., Souttou B., Guehenneux F., Gauthier L., Berthome M., Vie H., Beltraminelli N., Mehtali M. EB66 cell line, a duck embryonic stem cell-derived substrate for the industrial production of therapeutic monoclonal antibodies with enhanced ADCC activity. MAbs 2:405-415(2010) PubMed=21502045 Brown S.W., Mehtali M. The avian EB66(R) cell line, application to vaccines, and therapeutic protein production. PDA J. Pharm. Sci. Technol. 64:419-425(2010) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=26409141; DOI=10.1016/j.vaccine.2015.09.022 Naruse T., Fukuda T., Tanabe T., Ichikawa M., Oda Y., Tochihara S., Kimachi K., Kino Y., Ueda K. A clinical phase I study of an EB66 cell-derived H5N1 pandemic vaccine adjuvanted with AS03. Vaccine 33:6078-6084(2015) Patent=US9260694 Guehenneux F., Moreau K., Esnault M., Mehtali M. Generation of duck cell lines. Patent number US9260694, 16-Feb-2016 | http://www.valneva.com/en/technologies/82 |
ESK-4 | CVCL_3685 | / | / | diviak lesný | Sus scrofa | zvieracia | etická | ESK4; Embryonic Swine Kidney-4 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | obličkové | ženské | embryonálne | / | / | Patent=US4070453 Bordt D.E., Thomas P.C. Diploid porcine embryonic cell strains, cultures produced therefrom, and use of said cultures for production of vaccines. Patent number US4070453, 24-Jan-1978 PubMed=19508353; DOI=10.1111/j.1744-313X.2009.00853.x Ho C.S., Franzo-Romain M.H., Lee Y.J., Lee J.H., Smith D.M. Sequence-based characterization of swine leucocyte antigen alleles in commercially available porcine cell lines. Int. J. Immunogenet. 36:231-234(2009) | / |
FEL | CVCL_4199 | / | / | králik | Oryctolagus cuniculus | zvieracia | etická | Fibroblastes Embryonnaires de Lapin | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Characteristics: Susceptible to infection by rabies virus. | PubMed=4043531 Sureau P., Perrin P., Horaud F. A rabies vaccine produced in a non-tumorigenic rabbit cell line. Dev. Biol. Stand. 60:133-139(1985) | / |
GEK | CVCL_GU03 | / | / | koza domáca | Capra hircus | zvieracia | etická | Goat Embryonic Kidney | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | neurčené | embryonálne | / | Doubling time: ~49.5 hours (CelloPub=CLPUB00354). | CLPUB00354 Xiang M., Lu S., Gao Q.-H., Huang H.-J., Chen Z.-H., Tao B.-F., Zhan C.-Y., Qian Y.-G., Sun R.-L., Xia L., Tong W.-W., Wang L.-F., Hua J., Tao L.-W. A new cell line from goat embryonic kidney may be a candidate to produce influenza virus vaccine. Indian J. Anim. Sci. 85:828-831(2015) | / |
hCK | CVCL_WL43 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | HGNC; 10860; ST6GAL1 | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Characteristics: Will be useful for influenza virus research, particularly studies involving human A/H3N2 influenza viruses and possibly for vaccine production. Characteristics: Expresses large amounts of alpha-2,6-sialoglycans and small amounts of alpha-2,3-sialoglycans. Knockout cell: Method=CRISPR/Cas9; VGNC; 46850; ST3GAL1. Knockout cell: Method=CRISPR/Cas9; VGNC; 46851; ST3GAL2. Knockout cell: Method=CRISPR/Cas9; UniProtKB; F1PAE4; ST3GAL3. Knockout cell: Method=CRISPR/Cas9; VGNC; 46852; ST3GAL4. Knockout cell: Method=CRISPR/Cas9; VGNC; 46853; ST3GAL5. Knockout cell: Method=CRISPR/Cas9; VGNC; 46854; ST3GAL6. Knockout cell: Method=CRISPR/Cas9; UniProtKB; F1Q495; ST3GAL2L. | PubMed=31036910; DOI=10.1038/s41564-019-0433-6 Takada K., Kawakami C., Fan S., Chiba S., Zhong G., Gu C., Shimizu K., Takasaki S., Sakai-Tagawa Y., Lopes T.J.S., Dutta J., Khan Z., Kriti D., van Bakel H., Yamada S., Watanabe T., Imai M., Kawaoka Y. A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses. Nat. Microbiol. 4:1268-1273(2019) | / |
HEK293 | CVCL_0045 | Áno | CVCL_U658 (211A) CVCL_U659 (211B) CVCL_U660 (211R) CVCL_6351 (293 EcR Shh) CVCL_2285 (293 GTP-AC-free) CVCL_2286 (293 N3S) CVCL_4W25 (293 TRE/Cont) CVCL_4W26 (293 TRE/FLAG-POLK) CVCL_9832 (293-CD40) CVCL_4V25 (293-CD40L) CVCL_8468 (293-Db) CVCL_XI05 (293-ESM) CVCL_2283 (293-Hektor) CVCL_9831 (293-IL-1RI) CVCL_8469 (293-Kb) CVCL_A783 (293-LA) CVCL_VN85 (293-M7) CVCL_2284 (293-PERV-PK-CIRCE) CVCL_M907 (293-VnR) CVCL_RY64 (293_hEcad) CVCL_RY62 (293_hEcad/hSyn2) CVCL_RY72 (293_hSyn1) CVCL_RY63 (293_hSyn2) CVCL_RY68 (293_hSyn4) CVCL_DR94 (293/ACE2) CVCL_H362 (293/ADORA1/Galpha15) CVCL_KS32 (293/AP1-luc) CVCL_JZ01 (293/CFP) CVCL_6352 (293/CHE-Fc) CVCL_H364 (293/CRE-Luc) CVCL_KS33 (293/CREB-luc) CVCL_J499 (293/CrmA) CVCL_H366 (293/EP1) CVCL_H368 (293/FP/Galpha15) CVCL_JY88 (293/GFP) CVCL_H369 (293/GHRH/Galpha15) CVCL_KA76 (293/GNRHR/Galpha15) CVCL_H370 (293/H1) CVCL_Y384 (293/hMD2-CD14) CVCL_Y385 (293/hTLR1-HA) CVCL_Y417 (293/hTLR1-TLR2) CVCL_Y386 (293/hTLR10-HA) CVCL_Y387 (293/hTLR2) CVCL_Y388 (293/hTLR2-CD14) CVCL_Y389 (293/hTLR2-HA) CVCL_Y390 (293/hTLR2-TLR6) CVCL_Y391 (293/hTLR3) CVCL_Y392 (293/hTLR3-HA) CVCL_Y394 (293/hTLR4-HA) CVCL_Y393 (293/hTLR4A) CVCL_Y395 (293/hTLR4A-MD2-CD14) CVCL_Y396 (293/hTLR5) CVCL_Y397 (293/hTLR5-CD14) CVCL_Y398 (293/hTLR5-HA) CVCL_Y399 (293/hTLR6-HA) CVCL_9V14 (293/KDR) CVCL_Y101 (293/LacZ) CVCL_JY95 (293/Luc) CVCL_H372 (293/MCH1) CVCL_Y400 (293/mTLR1) CVCL_Y401 (293/mTLR1-TLR2) CVCL_Y402 (293/mTLR2) CVCL_Y403 (293/mTLR2-TLR6) CVCL_Y404 (293/mTLR3) CVCL_Y405 (293/mTLR4) CVCL_Y406 (293/mTLR4-MD2-CD14) CVCL_Y407 (293/mTLR5) CVCL_Y408 (293/mTLR6) CVCL_Y409 (293/mTLR9) CVCL_KS34 (293/NFkB-luc) CVCL_H373 (293/NPY1) CVCL_IM63 (293/pmiR-155) CVCL_IM64 (293/pmiR-K12-11) CVCL_UR29 (293/SF) CVCL_H375 (293/TP) CVCL_JY96 (293/YFP) CVCL_KA64 (293AAV) CVCL_KA63 (293AD) CVCL_E072 (293GP) CVCL_DD14 (293LAP10) CVCL_DD15 (293LAP13) CVCL_W338 (293RC21) CVCL_V648 (293sars181A) CVCL_Y381 (293XL/null) CVCL_6353 (2A) CVCL_6355 (2V6.11) CVCL_DD40 (35.32) CVCL_DD41 (37S2.8) CVCL_6361 (90.74) CVCL_6871 (AAV-293) CVCL_9804 (AD-293) CVCL_WI47 (AmphoPack-293) CVCL_W339 (AP-1 LUCPorter) CVCL_DD22 (BHH2C) CVCL_DD23 (BHH3) CVCL_DD24 (BHH8) CVCL_ZZ37 (C8) CVCL_9V15 (CRE8) CVCL_9867 (D1-HEK-293) CVCL_7261 (EcR-293) CVCL_VK71 (F2N78) CVCL_XB48 (FC33) CVCL_6902 (FIP293) CVCL_U421 (Flp-In-293) CVCL_U006 (Flp293A) CVCL_5285 (GFPu-1) CVCL_LB59 (GloResponse 9XGAL4UAS-luc2P HEK293) CVCL_LB60 (GloResponse CRE-luc2P HEK293) CVCL_LB61 (GloResponse NF-kappaB-RE-luc2P HEK293) CVCL_LB62 (GloResponse NFAT-RE-luc2P HEK293) CVCL_WI48 (GP2-293) CVCL_JQ47 (h-TREK-1/HEK) CVCL_KU63 (HEK 293 HTR2B Gq) CVCL_AQ26 (HEK 293 STF) CVCL_V349 (HEK 293 Tet-Off) CVCL_KU39 (HEK 293 Tet-Off Advanced) CVCL_KS31 (HEK 293 Tet-On) CVCL_V350 (HEK 293 Tet-On 3G) CVCL_KU43 (HEK 293 Tet-On Advanced) CVCL_V351 (HEK 293 tTS) CVCL_RQ74 (HEK 293/TLR3/NF-kB Luciferase Reporter) CVCL_RQ75 (HEK 293/TLR5/NF-kB Luciferase Reporter) CVCL_RQ76 (HEK 293/TLR7/NF-kB Luciferase Reporter) CVCL_RQ77 (HEK 293/TLR8/NF-kB Luciferase Reporter) CVCL_RQ78 (HEK 293/TLR9/NF-kB Luciferase Reporter) CVCL_YN15 (HEK-293 hNav1.9) CVCL_YN16 (HEK-293 mNav1.9) CVCL_YN17 (HEK-293 rNav1.9) CVCL_VT77 (HEK-293-AChE) CVCL_GR68 (HEK-293-Munc18b) CVCL_9868 (HEK-293-TrkB) CVCL_4W07 (HEK-293.2sus) CVCL_W457 (HEK-293B1) CVCL_9869 (HEK-293B2) CVCL_9870 (HEK-293CymR) CVCL_HB82 (HEK-3KO) CVCL_VV19 (HEK-Blue hDectin-1a) CVCL_VV20 (HEK-Blue hDectin-1b) CVCL_IM95 (HEK-Blue hMD2-CD14) CVCL_IM80 (HEK-Blue hTLR2) CVCL_IM81 (HEK-Blue hTLR3) CVCL_IM82 (HEK-Blue hTLR4) CVCL_IM83 (HEK-Blue hTLR5) CVCL_IM84 (HEK-Blue hTLR7) CVCL_IM85 (HEK-Blue hTLR8) CVCL_IM86 (HEK-Blue hTLR9) CVCL_KT26 (HEK-Blue IFN-alpha/beta) CVCL_UF30 (HEK-Blue IFN-gamma) CVCL_UF31 (HEK-Blue IL-12) CVCL_UF32 (HEK-Blue IL-17) CVCL_UF33 (HEK-Blue IL-18) CVCL_UF26 (HEK-Blue IL-2) CVCL_UF59 (HEK-Blue IL-33) CVCL_UF60 (HEK-Blue IL-6) CVCL_5I78 (HEK-Blue KD-TLR5) CVCL_VV21 (HEK-Blue mDectin-1b) CVCL_VV23 (HEK-Blue mDectin-2) CVCL_VV22 (HEK-Blue mMincle) CVCL_IM94 (HEK-Blue mTLR13) CVCL_IM87 (HEK-Blue mTLR2) CVCL_IM88 (HEK-Blue mTLR3) CVCL_IM89 (HEK-Blue mTLR4) CVCL_IM90 (HEK-Blue mTLR5) CVCL_IM91 (HEK-Blue mTLR7) CVCL_IM92 (HEK-Blue mTLR8) CVCL_IM93 (HEK-Blue mTLR9) CVCL_UF25 (HEK-Blue TNF-alpha) CVCL_E339 (HEK-CaSR) CVCL_WN84 (HEK-ptdTomato-N1 8) CVCL_IM79 (HEK-TLR2) CVCL_VI43 (HEK-TLR2-YFP) CVCL_VI44 (HEK-TLR4-YFP) CVCL_VI46 (HEK-TLR9-YFP) CVCL_2H48 (HEK1.1) CVCL_5I96 (HEK293 (+Galpha16) AequoScreen) CVCL_0296 (HEK293 482R) CVCL_ZV87 (HEK293 Actin-cpstFRET-Actin) CVCL_ZV88 (HEK293 Actinin-C-cpstFRET) CVCL_ZV89 (HEK293 Actinin-M-cpstFRET) CVCL_YJ96 (HEK293 ADCYAP1R1 HiTSeeker) CVCL_YJ97 (HEK293 ADORA2A HiTSeeker) CVCL_YJ98 (HEK293 ADORA2B HiTSeeker) CVCL_YJ99 (HEK293 ADRB2 HiTSeeker) CVCL_YK00 (HEK293 ADRB3 HiTSeeker) CVCL_5I97 (HEK293 AequoScreen) CVCL_YK01 (HEK293 AVPR1A HiTSeeker) CVCL_YK02 (HEK293 BDKRB1 HiTSeeker) CVCL_YK03 (HEK293 BDKRB2 HiTSeeker) CVCL_YK04 (HEK293 CALCR HiTSeeker) CVCL_UR28 (HEK293 Cas9) CVCL_HC62 (HEK293 Cav3.1) CVCL_HC63 (HEK293 Cav3.2) CVCL_HC64 (HEK293 Cav3.3) CVCL_YK05 (HEK293 CCKBR arrestin-Nomad) CVCL_YK06 (HEK293 CCKBR calcium-Nomad) CVCL_UF04 (HEK293 CD63 CRISPR) CVCL_YK07 (HEK293 CHRM1 HiTSeeker) CVCL_YI91 (HEK293 CNR1 cAMP-Nomad) CVCL_YK08 (HEK293 CNR1 HiTSeeker) CVCL_YK09 (HEK293 CNR2 HiTSeeker) CVCL_ZV86 (HEK293 cpstFRET-Actin) CVCL_YK10 (HEK293 CRHR2 HiTSeeker) CVCL_UH22 (HEK293 CYP19A1*1) CVCL_UH23 (HEK293 CYP19A1*3) CVCL_UH24 (HEK293 CYP19A1*4) CVCL_UG79 (HEK293 CYP1A1*1) CVCL_UG80 (HEK293 CYP1A1*1-V5) CVCL_UG81 (HEK293 CYP1A2*1A) CVCL_UG82 (HEK293 CYP1A2*1A-V5) CVCL_UG83 (HEK293 CYP1A2*21) CVCL_UG86 (HEK293 CYP2A13*1A) CVCL_UG87 (HEK293 CYP2A13*1A-V5) CVCL_UG84 (HEK293 CYP2A6*1A) CVCL_UG85 (HEK293 CYP2A6*1A-V5) CVCL_UG89 (HEK293 CYP2B6*1-V5) CVCL_UH00 (HEK293 CYP2C18*1-V5) CVCL_UH02 (HEK293 CYP2C19*1A-V5) CVCL_UH03 (HEK293 CYP2C19*1B-V5) CVCL_UH05 (HEK293 CYP2C19-E92D-V5) CVCL_UG90 (HEK293 CYP2C8*1-V5) CVCL_UG91 (HEK293 CYP2C8*2-V5) CVCL_UG92 (HEK293 CYP2C8*3-V5) CVCL_UG93 (HEK293 CYP2C8*4-V5) CVCL_UG94 (HEK293 CYP2C9*1) CVCL_UG95 (HEK293 CYP2C9*1-V5) CVCL_UG96 (HEK293 CYP2C9*2-V5) CVCL_UG97 (HEK293 CYP2C9*3-V5) CVCL_UG98 (HEK293 CYP2C9*8-V5) CVCL_UG99 (HEK293 CYP2C9*9-V5) CVCL_UH09 (HEK293 CYP2D6*10) CVCL_UH10 (HEK293 CYP2D6*17-V5) CVCL_UH07 (HEK293 CYP2D6*1A-V5) CVCL_UH08 (HEK293 CYP2D6*2-V5) CVCL_UH11 (HEK293 CYP2E1*1A) CVCL_UH12 (HEK293 CYP2E1*1A-V5) CVCL_UH13 (HEK293 CYP2J2*1-V5) CVCL_UH16 (HEK293 CYP3A4*15-V5) CVCL_UH15 (HEK293 CYP3A4*1A-V5) CVCL_UH17 (HEK293 CYP3A5*1) CVCL_UH18 (HEK293 CYP3A5*1-V5) CVCL_UH20 (HEK293 CYP3A7*2-V5) CVCL_UH21 (HEK293 CYP4A11*1-V5) CVCL_YK11 (HEK293 DRD1 cAMP-Nomad) CVCL_YK12 (HEK293 DRD1 HiTSeeker) CVCL_YK13 (HEK293 DRD5 HiTSeeker) CVCL_YK14 (HEK293 FSHR Fluo-HiTSeeker) CVCL_YK15 (HEK293 FSHR HiTSeeker) CVCL_XZ52 (HEK293 human APP695) CVCL_XZ53 (HEK293 human APP695 Swedish) CVCL_YK16 (HEK293 LHCGR Fluo-HiTSeeker) CVCL_YK17 (HEK293 LHCGR HiTSeeker) CVCL_YK18 (HEK293 MC4R HiTSeeker) CVCL_ZW92 (HEK293 Nav1.7) CVCL_KS50 (HEK293 p65-HaloTag) CVCL_YK19 (HEK293 PTGER2 HiTSeeker) CVCL_YK20 (HEK293 PTGER4 HiTSeeker) CVCL_RY69 (HEK293 rLN10) CVCL_YD69 (HEK293 RPS2 A226Y) CVCL_YD70 (HEK293 RPS2 WT) CVCL_RY71 (HEK293 rLN8) CVCL_WS18 (HEK293 SCN1A/SCN1B/SCN2B) CVCL_S025 (HEK293 SimpleCell O-GalNAc) CVCL_YK21 (HEK293 TACR1 HiTSeeker) CVCL_YK22 (HEK293 tGFP-BACE1) CVCL_YK23 (HEK293 TSHR HiTSeeker) CVCL_YK24 (HEK293 VIPR1 HiTSeeker) CVCL_JZ97 (HEK293_GS-KO) CVCL_6910 (HEK293-A) CVCL_E149 (HEK293-A7) CVCL_ZD63 (HEK293-CAGA) CVCL_YJ21 (HEK293-CB1) CVCL_6974 (HEK293-EBNA) CVCL_EP72 (HEK293-EPHB1) CVCL_EP73 (HEK293-EPHB2) CVCL_6996 (HEK293-ET) CVCL_6642 (HEK293-F) CVCL_6643 (HEK293-H) CVCL_ZC53 (HEK293-hCNR1) CVCL_ZC54 (HEK293-hCNR2) CVCL_ZC15 (HEK293-hGPR55) CVCL_VP06 (HEK293-HM3) CVCL_WI13 (HEK293-hNOTCH1) CVCL_WI14 (HEK293-hNOTCH2) CVCL_VP07 (HEK293-HR1) CVCL_ZC55 (HEK293-mCnr1) CVCL_ZC56 (HEK293-mCnr2) CVCL_ZC16 (HEK293-mGpr55) CVCL_5I43 (HEK293-Nav 1.3) CVCL_WG86 (HEK293-Nrf2 clone 1) CVCL_WG87 (HEK293-Nrf2 clone 2) CVCL_ZC57 (HEK293-rCnr1) CVCL_ZC58 (HEK293-rCnr2) CVCL_VR42 (HEK293-SREBP1-T2A-luciferase-KI) CVCL_RZ86 (HEK293-YFV-prM/E-opt) CVCL_H513 (HEK293/5-HT2C) CVCL_H514 (HEK293/AT1) CVCL_KA11 (HEK293/Galpha15) CVCL_H515 (HEK293/GCGR/Galpha15) CVCL_5A22 (HEK293/GFP-DFCP1) CVCL_H516 (HEK293/hERG) CVCL_H517 (HEK293/hKv1.5) CVCL_H518 (HEK293/hKv4.2) CVCL_H519 (HEK293/hNav1.5) CVCL_H520 (HEK293/hNav1.7) CVCL_KA65 (HEK293/NFAT/beta-lactamase) CVCL_KA07 (HEK293/PD-L1) CVCL_KA75 (HEK293/PTHR1/CRE/beta-lactamase) CVCL_M775 (HEK293L) CVCL_A784 (HEK293S) CVCL_0063 (HEK293T) CVCL_UL49 (HEK293TN) CVCL_HB83 (HEKR1) CVCL_HB84 (HEKR2) CVCL_HB85 (HEKR2R1) CVCL_HB86 (HEKR2R3) CVCL_HB87 (HEKR3) CVCL_HB88 (HEKR3R1) CVCL_2491 (HH-8) CVCL_E065 (HKb20) CVCL_N700 (HL-2) CVCL_WK50 (iLite VEGF Assay Ready Cells) CVCL_KW01 (InCELL Hunter HEK 293 BAZ2A Bromodomain) CVCL_KW02 (InCELL Hunter HEK 293 BRD2(1) Bromodomain) CVCL_KW03 (InCELL Hunter HEK 293 BRD2(1,2) Bromodomain) CVCL_KW04 (InCELL Hunter HEK 293 BRD3(1) Bromodomain) CVCL_KW05 (InCELL Hunter HEK 293 BRD3(1,2) Bromodomain) CVCL_KW06 (InCELL Hunter HEK 293 BRD4(1) Bromodomain) CVCL_KW07 (InCELL Hunter HEK 293 BRDT(1) Bromodomain) CVCL_KW08 (InCELL Hunter HEK 293 BRDT(1,2) Bromodomain) CVCL_KW09 (InCELL Hunter HEK 293 SMARCA4 Bromodomain) CVCL_KW10 (InCELL Hunter HEK 293 TAF1L(2) Bromodomain) CVCL_5I63 (K177) CVCL_YJ80 (LINTERNA HEK293) CVCL_0406 (MAIL8) CVCL_A9P3 (NF-KappaB reporter (Luc)-HEK293) CVCL_ZL50 (NOX1-HEK293) CVCL_ZL51 (NOX4-HEK293) CVCL_KZ31 (PathHunter HEK 293 ADRA1D(82-572) beta-arrestin) CVCL_KZ32 (PathHunter HEK 293 ADRB2 Total GPCR Internalization) CVCL_KZ33 (PathHunter HEK 293 AVPR2 beta-arrestin) CVCL_KZ34 (PathHunter HEK 293 BDKRB2 beta-arrestin) CVCL_KZ35 (PathHunter HEK 293 beta-arrestin1-EA Parental) CVCL_KZ36 (PathHunter HEK 293 beta-arrestin2-EA Parental) CVCL_KZ37 (PathHunter HEK 293 CCKAR beta-arrestin) CVCL_KZ38 (PathHunter HEK 293 CCR2 beta-arrestin) CVCL_KZ39 (PathHunter HEK 293 CCR7 beta-arrestin) CVCL_KZ40 (PathHunter HEK 293 CNR2 beta-arrestin) CVCL_KZ41 (PathHunter HEK 293 CXCR2 beta-arrestin) CVCL_KZ42 (PathHunter HEK 293 CXCR6 beta-arrestin) CVCL_KZ43 (PathHunter HEK 293 cyno CXCR1 beta-arrestin) CVCL_KZ44 (PathHunter HEK 293 cyno CXCR2 beta-arrestin) CVCL_KZ45 (PathHunter HEK 293 EDG1 Total GPCR Internalization) CVCL_KZ46 (PathHunter HEK 293 EDG3 beta-arrestin) CVCL_KZ47 (PathHunter HEK 293 F2RL1 beta-arrestin) CVCL_KZ48 (PathHunter HEK 293 FFAR1 beta-arrestin-1) CVCL_KZ49 (PathHunter HEK 293 GCGR Total GPCR Internalization) CVCL_KZ50 (PathHunter HEK 293 GPR119 beta-arrestin) CVCL_KZ51 (PathHunter HEK 293 GPR120L Total GPCR Internalization) CVCL_KZ52 (PathHunter HEK 293 GPR150 beta-arrestin) CVCL_KZ53 (PathHunter HEK 293 GPR152 beta-arrestin) CVCL_KZ54 (PathHunter HEK 293 GPR173 beta-arrestin) CVCL_KZ55 (PathHunter HEK 293 GPR20 beta-arrestin) CVCL_KZ56 (PathHunter HEK 293 GPR45 beta-arrestin) CVCL_KZ57 (PathHunter HEK 293 GRPR beta-arrestin) CVCL_KZ58 (PathHunter HEK 293 IkappaB Degradation) CVCL_KZ59 (PathHunter HEK 293 LXRbeta-NCoR1 Protein Interaction) CVCL_KZ60 (PathHunter HEK 293 mGPR120 beta-arrestin) CVCL_KZ61 (PathHunter HEK 293 P2RY4 beta-arrestin) CVCL_KZ62 (PathHunter HEK 293 PTGER2 beta-arrestin) CVCL_KZ63 (PathHunter HEK 293 PTGER4 beta-arrestin) CVCL_KZ64 (PathHunter HEK 293 PTGIR beta-arrestin) CVCL_KZ65 (PathHunter HEK 293 RELA-IkappaB Nuclear Translocation) CVCL_KZ66 (PathHunter HEK 293 SCTR beta-arrestin) CVCL_KZ67 (PathHunter HEK 293 SSTR3 beta-arrestin) CVCL_3772 (pEAK Rapid) CVCL_JY47 (PLT460F_(DDR2)) CVCL_RQ69 (PrecisION hCav1.2 alpha1C/beta2a/alpha2-delta1-HEK) CVCL_LC62 (PrecisION hERG-HEK) CVCL_RQ84 (PrecisION hHCN1-HEK) CVCL_RQ85 (PrecisION hHCN2-HEK) CVCL_RQ83 (PrecisION hHCN3-HEK) CVCL_RQ81 (PrecisION hNav1.1-HEK) CVCL_LC67 (PrecisION hNav1.5-HEK) CVCL_LC68 (PrecisION hNav1.6-HEK) CVCL_RQ80 (PrecisION hNav1.7-HEK) CVCL_8967 (ProPak-A.52) CVCL_8968 (ProPak-A.6) CVCL_8969 (ProPak-X.36) CVCL_VQ64 (SCL215) CVCL_VQ89 (SCL60) CVCL_6448 (SODk1) CVCL_D585 (T-REx-293) CVCL_8117 (Tet-iNOS-293) CVCL_2737 (tsA201) CVCL_5I80 (ValiScreen human TRPC3) CVCL_5I81 (ValiScreen human TRPC6) CVCL_YJ67 (VAMPIRO HEK293) CVCL_2767 (WSS-1) | človek | Homo sapiens | ľudská | neetická | Hek293; HEK-293; HEK/293; HEK 293; HEK;293; 293; 293 HEK; 293 Ad5; Human Embryonic Kidney 293 | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 | / | Transformované bunkové línie | obličkové | ženské | embryonálne | / | Part of: ENCODE project common cell types; tier 3. Part of: MD Anderson Cell Lines Project. Doubling time: ~30 hours (CLS); ~24-30 hours (DSMZ). Transformant: NCBI_TaxID; 28285; Adenovirus 5. Omics: Cell surface proteome. Omics: Deep antibody staining analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: Genome sequenced. Omics: DNA methylation analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: Metabolome analysis. Omics: Methylated arginine analysis by proteomics. Omics: Myristoylated proteins analysis by proteomics. Omics: Protein expression by reverse-phase protein arrays. Omics: Transcriptome analysis. Omics: Virome analysis using proteomics. Misspelling: HECK293; Occasionally. Misspelling: HEK239; Occasionally. | PubMed=886304; DOI=10.1099/0022-1317-36-1-59 Graham F.L., Smiley J., Russell W.C., Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-74(1977) PubMed=9217065; DOI=10.1006/viro.1997.8597 Louis N., Evelegh C., Graham F.L. Cloning and sequencing of the cellular-viral junctions from the human adenovirus type 5 transformed 293 cell line. Virology 233:423-429(1997) PubMed=15218237; DOI=10.1159/000078556 Bylund L., Kytola S., Lui W.-O., Larsson C., Weber G. Analysis of the cytogenetic stability of the human embryonal kidney cell line 293 by cytogenetic and STR profiling approaches. Cytogenet. Genome Res. 106:28-32(2004) PubMed=21502043 Rubino M.J. Experiences with HEK293: a human cell line. PDA J. Pharm. Sci. Technol. 64:392-395(2010) PubMed=21214938; DOI=10.1186/1471-2164-12-14 Atwood B.K., Lopez J., Wager-Miller J., Mackie K., Straiker A. Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. BMC Genomics 12:14-14(2011) PubMed=21269460; DOI=10.1186/1752-0509-5-17 Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J. Initial characterization of the human central proteome. BMC Syst. Biol. 5:17-17(2011) PubMed=22278370; DOI=10.1074/mcp.M111.014050 Geiger T., Wehner A., Schaab C., Cox J., Mann M. Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012) PubMed=23325432; DOI=10.1101/gr.147942.112 Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M. Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res. 23:555-567(2013) PubMed=24618588; DOI=10.1371/journal.pone.0091433 Chernobrovkin A.L., Zubarev R.A. Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins. PLoS ONE 9:E91433-E91433(2014) PubMed=25182477; DOI=10.1038/ncomms5767 Lin Y.-C., Boone M., Meuris L., Lemmens I., Van Roy N., Soete A., Reumers J., Moisse M., Plaisance S., Drmanac R., Chen J., Speleman F., Lambrechts D., Van de Peer Y., Tavernier J., Callewaert N. Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations. Nat. Commun. 5:4767-4767(2014) PubMed=25960936; DOI=10.4161/21624011.2014.954893 Boegel S., Lower M., Bukur T., Sahin U., Castle J.C. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. OncoImmunology 3:E954893-E954893(2014) PubMed=25807930; DOI=10.1002/anie.201500342 Broncel M., Serwa R.A., Ciepla P., Krause E., Dallman M.J., Magee A.I., Tate E.W. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. Angew. Chem. Int. Ed. 54:5948-5951(2015) PubMed=25894527; DOI=10.1371/journal.pone.0121314 Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B. A mass spectrometric-derived cell surface protein atlas. PLoS ONE 10:E0121314-E0121314(2015) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=27233776; DOI=10.1002/pmic.201500349 Lobas A.A., Karpov D.S., Kopylov A.T., Solovyeva E.M., Ivanov M.V., Ilina I.Y., Lazarev V.N., Kuznetsova K.G., Ilgisonis E.V., Zgoda V.G., Gorshkov M.V., Moshkovskii S.A. Exome-based proteogenomics of HEK-293 human cell line: coding genomic variants identified at the level of shotgun proteome. Proteomics 16:1980-1991(2016) PubMed=27577262; DOI=10.1126/scisignal.aaf7329 Larsen S.C., Sylvestersen K.B., Mund A., Lyon D., Mullari M., Madsen M.V., Daniel J.A., Jensen L.J., Nielsen M.L. Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells. Sci. Signal. 9:Rs9-Rs9(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) DOI=10.13005/bpj/1414 Yuan J., Xu W.W.-W., Jiang S.Y.-L., Yu H.X.-Y., Poon H.-F. The scattered twelve tribes of HEK293. Biomed. Pharmacol. J. 11:621-623(2018) PubMed=29660373; DOI=10.1016/j.bbagen.2018.04.012 Touat-Hamici Z., Bulteau A.-L., Bianga J., Jean-Jacques H., Szpunar J., Lobinski R., Chavatte L. Selenium-regulated hierarchy of human selenoproteome in cancerous and immortalized cells lines. Biochim. Biophys. Acta 1862:2493-2505(2018) PubMed=30260228; DOI=10.1021/acs.jproteome.8b00538 Knott M.E., Manzi M., Zabalegui N., Salazar M.O., Puricelli L.I., Monge M.E. Metabolic footprinting of a clear cell renal cell carcinoma in vitro model for human kidney cancer detection. J. Proteome Res. 17:3877-3888(2018) | https://en.wikipedia.org/wiki/HEK_293_cells |
Hi-5 Rix4446 | CVCL_RW20 | CVCL_C190 (BTI-Tn-5B1-4) | / | kapustník | Trichoplusia ni | zvieracia | etická | Hi-5 Rix 4446; Rix4446 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Insect cell line. Group: Recombinant protein production insect cell line. Biotechnology: Used for the production of the papilloma vaccine Cervarix. The C-terminally truncated protein L1 of HPV-16 and HPV-18 are separately produced in this cell line using a recombinantBaculovirus expression system. | / | |
HP PER.C6 | CVCL_A9E7 | CVCL_G704 (PER.C6) | / | človek | Homo sapiens | ľudská | neetická | Higher passage PER.C6 | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1] | / | Transformované bunkové línie | očné | neurčené | embryonálne | / | Characteristics: Has a greater capacity for adenovirus production than the parent cell line and is better adapted to suspension culture growth (PubMed=18052336). | PubMed=18052336; DOI=10.1021/bp070258u Berdichevsky M., Gentile M.P., Hughes B., Meis P., Peltier J., Blumentals I., Aunins J., Altaras N.E. Establishment of higher passage PER.C6 cells for adenovirus manufacture. Biotechnol. Prog. 24:158-165(2008) | |
IDE1 | CVCL_Z164 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Tick cell line. | PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 | |
IDE12 | CVCL_Z165 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | zmiešané | embryonálne | / | Group: Tick cell line. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. | PubMed=8057317; DOI=10.1093/jmedent/31.3.425 Chen C.-S., Munderloh U.G., Kurtti T.J. Cytogenetic characteristics of cell lines from Ixodes scapularis (Acari: Ixodidae). J. Med. Entomol. 31:425-434(1994) PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002 Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L. Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis. 3:137-146(2012) PubMed=25894426; DOI=10.1007/s10493-015-9908-1 Oliver J.D., Chavez A.S.O., Felsheim R.F., Kurtti T.J., Munderloh U.G. An Ixodes scapularis cell line with a predominantly neuron-like phenotype. Exp. Appl. Acarol. 66:427-442(2015) | https://www.dsmz.de/fileadmin/Bereiche/Microbiology/Dateien/Kultivierungshinweise/TickCellCultureMethods-4.pdf |
IDE2 | CVCL_Z166 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Tick cell line. Omics: Deep RNAseq analysis. | PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) PubMed=9364140; DOI=10.1099/00222615-46-10-839 Policastro P.F., Munderloh U.G., Fischer E.R., Hackstadt T. Rickettsia rickettsii growth and temperature-inducible protein expression in embryonic tick cell lines. J. Med. Microbiol. 46:839-845(1997) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=11257184; DOI=10.1099/0022-1317-82-4-795 Attoui H., Stirling J.M., Munderloh U.G., Billoir F., Brookes S.M., Burroughs J.N., de Micco P., Mertens P.P.C., de Lamballerie X. Complete sequence characterization of the genome of the St Croix River virus, a new orbivirus isolated from cells of Ixodes scapularis. J. Gen. Virol. 82:795-804(2001) PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002 Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L. Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis. 3:137-146(2012) PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015 Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L. The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit. Ticks Tick Borne Dis. 9:1364-1371(2018) | https://www.liverpool.ac.uk/infection-and-global-health/research/tick-cell-biobank/tick-cell-lines/ |
IDE8 | CVCL_Z167 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | zmiešané | embryonálne | / | Group: Tick cell line. Omics: Deep RNAseq analysis. | PubMed=8057317; DOI=10.1093/jmedent/31.3.425 Chen C.-S., Munderloh U.G., Kurtti T.J. Cytogenetic characteristics of cell lines from Ixodes scapularis (Acari: Ixodidae). J. Med. Entomol. 31:425-434(1994) PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) PubMed=8812616; DOI=10.1006/jipa.1996.0050 Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A., Mather T.N. Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis. J. Invertebr. Pathol. 67:318-321(1996) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=15053931; DOI=10.1016/j.jcpa.2003.12.002 Bell-Sakyi L. Ehrlichia ruminantium grows in cell lines from four ixodid tick genera. J. Comp. Pathol. 130:285-293(2004) PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) PubMed=20388200; DOI=10.1186/1756-3305-3-37 Lallinger G., Zweygarth E., Bell-Sakyi L., Passos L.M.F. Cold storage and cryopreservation of tick cell lines. Parasit. Vectors 3:37-37(2010) PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002 Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L. Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis. 3:137-146(2012) PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015 Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L. The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit. Ticks Tick Borne Dis. 9:1364-1371(2018) PubMed=32158404; DOI=10.3389/fphys.2020.00152 Al-Rofaai A., Bell-Sakyi L. Tick cell lines in research on tick control. Front. Physiol. 11:152-152(2020) | https://www.dsmz.de/fileadmin/Bereiche/Microbiology/Dateien/Kultivierungshinweise/TickCellCultureMethods-4.pdf |
ISE18 | CVCL_Z168 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | zmiešané | embryonálne | / | Group: Tick cell line. Omics: Deep RNAseq analysis. | PubMed=8057317; DOI=10.1093/jmedent/31.3.425 Chen C.-S., Munderloh U.G., Kurtti T.J. Cytogenetic characteristics of cell lines from Ixodes scapularis (Acari: Ixodidae). J. Med. Entomol. 31:425-434(1994) PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002 Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L. Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis. 3:137-146(2012) PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015 Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L. The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit. Ticks Tick Borne Dis. 9:1364-1371(2018) PubMed=32778731; DOI=10.1038/s41598-020-70330-5 Kotsarenko K., Vechtova P., Lieskovska J., Fussy Z., Cabral-de-Mello D.C., Rego R.O.M., Alberdi P., Collins M., Bell-Sakyi L., Sterba J., Grubhoffer L. Karyotype changes in long-term cultured tick cell lines. Sci. Rep. 10:13443-13443(2020) | https://www.vectorbase.org/vbsearch/details/VBRNAseq_group_1255 |
ISE5 | CVCL_Z169 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Tick cell line. Misspelling: ISE25; In PubMed=8812616. | PubMed=8064520; DOI=10.2307/3283188 Munderloh U.G., Liu Y., Wang M.-M., Chen C.-S., Kurtti T.J. Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J. Parasitol. 80:533-543(1994) PubMed=8812616; DOI=10.1006/jipa.1996.0050 Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A., Mather T.N. Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis. J. Invertebr. Pathol. 67:318-321(1996) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) | / |
ISE6 | CVCL_Z170 | / | / | kliešť čiernonohý | Ixodes scapularis | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | embryonálne | / | Group: Tick cell line. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: Metabolome analysis. | PubMed=8812616; DOI=10.1006/jipa.1996.0050 Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A., Mather T.N. Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis. J. Invertebr. Pathol. 67:318-321(1996) Patent=US5869335 Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A. Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever. Patent number US5869335, 09-Feb-1999 PubMed=16922866; DOI=10.1111/j.1462-5822.2006.00727.x Singu V., Peddireddi L., Sirigireddy K.R., Cheng C.-M., Munderloh U.G., Ganta R.R. Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis. Cell. Microbiol. 8:1475-1487(2006) PubMed=17662657; DOI=10.1016/j.pt.2007.07.009 Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F. Tick cell lines: tools for tick and tick-borne disease research. Trends Parasitol. 23:450-457(2007) PubMed=19242658; DOI=10.1007/s10493-009-9255-1 Billeter S.A., Diniz P.P.V.P., Battisti J.M., Munderloh U.G., Breitschwerdt E.B., Levy M.G. Infection and replication of Bartonella species within a tick cell line. Exp. Appl. Acarol. 49:193-208(2009) PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002 Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L. Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. Ticks Tick Borne Dis. 3:137-146(2012) PubMed=25894426; DOI=10.1007/s10493-015-9908-1 Oliver J.D., Chavez A.S.O., Felsheim R.F., Kurtti T.J., Munderloh U.G. An Ixodes scapularis cell line with a predominantly neuron-like phenotype. Exp. Appl. Acarol. 66:427-442(2015) PubMed=26424601; DOI=10.1074/mcp.M115.051938 Villar M., Ayllon N., Alberdi P., Moreno A., Moreno M., Tobes R., Mateos-Hernandez L., Weisheit S., Bell-Sakyi L., de la Fuente J. Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells. Mol. Cell. Proteomics 14:3154-3172(2015) PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015 Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L. The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit. Ticks Tick Borne Dis. 9:1364-1371(2018) PubMed=32158404; DOI=10.3389/fphys.2020.00152 Al-Rofaai A., Bell-Sakyi L. Tick cell lines in research on tick control. Front. Physiol. 11:152-152(2020) | https://www.liverpool.ac.uk/infection-and-global-health/research/tick-cell-biobank/tick-cell-lines/ |
KST | CVCL_6A74 | / | / | tur domáci | Bos taurus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | / | neurčené | embryonálne | / | / | PubMed=24000610 Bekhzadpur D., Belousova R.V., Ivanov I.V. Substantiation of optimum condition of parainfluenza-3 virus cultivation for production of vaccines on the finite cell line. Voen. Med. Zh. 334:27-31(2013) | http://www.rccc.cytspb.rssi.ru/ecellbank/animal/akst.htm |
LEK | CVCL_F742 | / | / | tur domáci | Bos taurus | zvieracia | etická | Legkoye Embrion Korova | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | / | neurčené | embryonálne | / | / | PubMed=24000610 Bekhzadpur D., Belousova R.V., Ivanov I.V. Substantiation of optimum condition of parainfluenza-3 virus cultivation for production of vaccines on the finite cell line. Voen. Med. Zh. 334:27-31(2013) | http://www.rccc.cytspb.rssi.ru/ecellbank/animal/alek.htm |
MDCC-JMV-1 | CVCL_T449 | / | / | kura bankivská | Gallus gallus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 10390; Gallid herpesvirus 2 (Marek's disease virus) | / | Rakovinové bunkové línie | / | neurčené | / | / | Group: Bird cell line. | PubMed=208974 Munch D., Hohlstein L., Sevoian M. In vitro establishment of Marek's disease herpesvirus-transformed productive and nonproductive lymphoblastoid cell lines. Infect. Immun. 20:315-318(1978) Patent=EP0244760A2 Sevoian M. Vaccine for the prevention of Marek's disease. Patent number EP0244760A2, 11-Nov-1987 PubMed=18766641; DOI=10.1080/03079458708436402 Nazerian K. An updated list of avian cell lines and transplantable tumours. Avian Pathol. 16:527-544(1987) PubMed=18670936; DOI=10.1080/03079459208418839 Keller L.H., Lillehoj H.S., Solnosky J.M. JMV-1 stimulation of avian natural killer cell activity. Avian Pathol. 21:239-250(1992) | / |
MDCK | CVCL_0422 | Áno | CVCL_4164 (DoCl1 (S+L-)) CVCL_WL43 (hCK) CVCL_YJ87 (LINTERNA MDCK)CVCL_GY95 (Luc9.1) CVCL_2A36 (MDCK 33016) CVCL_DF69 (MDCK 9B9-1B1)CVCL_DF70 (MDCK 9B9-1E4) CVCL_ZV91 (MDCK Actin-cpstFRET-Actin) CVCL_ZV92 (MDCK Actinin-C-cpstFRET)CVCL_ZV93 (MDCK Actinin-M-cpstFRET) CVCL_ZV90 (MDCK cpstFRET-Actin) CVCL_AP67 (MDCK Sky1023)CVCL_AP68 (MDCK Sky10234) CVCL_AP69 (MDCK Sky3851) CVCL_V359 (MDCK Tet-Off)CVCL_WL59 (MDCK-6A8) CVCL_K177 (MDCK-AD) CVCL_AP66 (MDCK-B-702)CVCL_AP70 (MDCK-C11) CVCL_0423 (MDCK-C7) CVCL_DF31 (MDCK-chAbcb1)CVCL_AQ31 (MDCK-E [Korea]) CVCL_Y089 (MDCK-E [Taiwan]) CVCL_AP75 (MDCK-F)CVCL_0592 (MDCK-I) CVCL_0424 (MDCK-II) CVCL_IZ19 (MDCK-P-gp)CVCL_JX35 (MDCK-Protein Free) CVCL_IQ72 (MDCK-S) CVCL_IQ73 (MDCK-SF101)CVCL_IQ74 (MDCK-SF102) CVCL_IQ75 (MDCK-SF103) CVCL_WL74 (MDCK-SFS)CVCL_Z936 (MDCK-SIAT1) CVCL_B033 (MDCK.1) CVCL_B034 (MDCK.2)CVCL_DE56 (MDCK.5F1) CVCL_2586 (MDCK.P3) CVCL_YZ44 (MDCK.STAT1 KO)CVCL_WL70 (MDCK.SUS1) CVCL_K241 (MDCK/60) CVCL_WC98 (MDCK/IgR)CVCL_WL76 (ssf-MDCK) CVCL_6452 (Super Dome) CVCL_6453 (Super Tube) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Caution: There seems to be two distinct cell lines which were assigned NCBI_Iran catalog number C426. | PubMed=13901412; DOI=10.1126/science.138.3536.42 Green I.J. Serial propagation of influenza B (Lee) virus in a transmissible line of canine kidney cells. Science 138:42-43(1962) PubMed=5918973; DOI=10.3181/00379727-122-31293 Gaush C.R., Hard W.L., Smith T.F. Characterization of an established line of canine kidney cells (MDCK). Proc. Soc. Exp. Biol. Med. 122:931-935(1966) PubMed=222773; DOI=10.1083/jcb.81.3.635 Rindler M.J., Chuman L.M., Shaffer L., Saier M.H. Jr. Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). J. Cell Biol. 81:635-648(1979) PubMed=12667817; DOI=10.1016/S0042-6822(02)00064-8 Romanova J., Katinger D., Ferko B., Voglauer R., Mochalova L., Bovin N., Lim W., Katinger H., Egorov A. Distinct host range of influenza H3N2 virus isolates in Vero and MDCK cells is determined by cell specific glycosylation pattern. Virology 307:90-97(2003) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=21819694 Omeir R.L., Teferedegne B., Foseh G.S., Beren J.J., Snoy P.J., Brinster L.R., Cook J.L., Peden K., Lewis A.M. Jr. Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby canine kidney cells. Comp. Med. 61:243-250(2011) PubMed=21982418; DOI=10.1186/1471-2121-12-43 Dukes J.D., Whitley P., Chalmers A.D. The MDCK variety pack: choosing the right strain. BMC Cell Biol. 12:43-43(2011) PubMed=24058646; DOI=10.1371/journal.pone.0075014 Lugovtsev V.Y., Melnyk D., Weir J.P. Heterogeneity of the MDCK cell line and its applicability for influenza virus research. PLoS ONE 8:E75014-E75014(2013) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) | https://en.wikipedia.org/wiki/Madin-Darby_Canine_Kidney_Cells |
MDCK 33016 | CVCL_2A36 | CVCL_0422 (MDCK) | CVCL_2A37 (MDCK 33016-PF) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK-33016 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2219 | Patent=US6455298 Groner A., Vorlop J. Animal cells and processes for the replication of influenza viruses. Patent number US6455298, 24-Sep-2002 PubMed=18485545; DOI=10.1016/j.vaccine.2008.03.075 Gregersen J.-P. A quantitative risk assessment of exposure to adventitious agents in a cell culture-derived subunit influenza vaccine. Vaccine 26:3332-3340(2008) | / |
MDCK 33016-PF | CVCL_2A37 | CVCL_2A36 (MDCK 33016) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK 33016 PF; MDCK 33016PF; MDCK-33016PF; MDCK subline 33016-PF | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Biotechnology: Used for the production of the influenza vaccine Optaflu. | PubMed=20071567; DOI=10.1128/JVI.01925-09 Suphaphiphat P., Keiner B., Trusheim H., Crotta S., Tuccino A.B., Zhang P., Dormitzer P.R., Mason P.W., Franti M. Human RNA polymerase I-driven reverse genetics for influenza a virus in canine cells. J. Virol. 84:3721-3725(2010) | / |
MDCK 9B9-1B1 | CVCL_DF69 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | / | Patent=US8846032 Liu J., Schwartz R., Thompson M., Maranga L., Ghosh M., Subramanian A., Hsu S.S.-T. MDCK cell lines supporting viral growth to high titers and bioreactor process using the same. Patent number US8846032, 30-Sep-2014 | / |
MDCK 9B9-1E4 | CVCL_DF70 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | / | PubMed=20307595; DOI=10.1016/j.vaccine.2010.03.005 Hussain A.I., Cordeiro M., Sevilla E., Liu J. Comparison of egg and high yielding MDCK cell-derived live attenuated influenza virus for commercial production of trivalent influenza vaccine: in vitro cell susceptibility and influenza virus replication kinetics in permissive and semi-permissive cells. Vaccine 28:3848-3855(2010) PubMed=22902973; DOI=10.1016/j.biologicals.2012.06.005 Vepachedu R.S., Menon A., Hussain A.I., Liu J. Evaluation of tumorigenic potential of high yielding cloned MDCK cells for live-attenuated influenza vaccine using in vitro growth characteristics, metastatic gene expression and in vivo nude mice model. Biologicals 40:482-494(2012) Patent=US8846032 Liu J., Schwartz R., Thompson M., Maranga L., Ghosh M., Subramanian A., Hsu S.S.-T. MDCK cell lines supporting viral growth to high titers and bioreactor process using the same. Patent number US8846032, 30-Sep-2014 | / |
MDCK Sky1023 | CVCL_AP67 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. | Patent=US9447383 Park Y.W., Lee K.S., Lee B.-Y., Park M., Kim H., Kim Y.-H., Lee S.-J. MDCK-derived cell lines adapted to serum-free culture and suspension culture and method for preparing vaccine virus using the cells. Patent number US9447383, 20-Sep-2016 | / |
MDCK Sky10234 | CVCL_AP68 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-3114. | Patent=US9447383 Park Y.W., Lee K.S., Lee B.-Y., Park M., Kim H., Kim Y.-H., Lee S.-J. MDCK-derived cell lines adapted to serum-free culture and suspension culture and method for preparing vaccine virus using the cells. Patent number US9447383, 20-Sep-2016 | / |
MDCK Sky3851 | CVCL_AP69 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-3113. | Patent=US9447383 Park Y.W., Lee K.S., Lee B.-Y., Park M., Kim H., Kim Y.-H., Lee S.-J. MDCK-derived cell lines adapted to serum-free culture and suspension culture and method for preparing vaccine virus using the cells. Patent number US9447383, 20-Sep-2016 | / |
MDCK-B-702 | CVCL_AP66 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | B-702 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-7449. | Patent=US6825036 Makizumi K., Masuda K., Kino Y., Tokiyoshi S. Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell. Patent number US6825036, 30-Nov-2004 | / |
MDCK-I | CVCL_0592 | CVCL_0422 (MDCK) | CVCL_VR38 (gMDCKI) CVCL_GZ12 (MDCKts.src) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK I; MDCKI; MDCK1; MDCK-1 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | / | PubMed=21982418; DOI=10.1186/1471-2121-12-43 Dukes J.D., Whitley P., Chalmers A.D. The MDCK variety pack: choosing the right strain. BMC Cell Biol. 12:43-43(2011) PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045 Donis R.O., Chen I.-M., Davis C.T., Foust A., Hossain M.J., Johnson A., Klimov A., Loughlin R., Xu X., Tsai T., Blayer S., Trusheim H., Colegate T., Fox J., Taylor B., Hussain A., Barr I., Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen O., Neumeier E., Ziegler T. Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing. Vaccine 32:6583-6590(2014) | / |
MDCK-II | CVCL_0424 | CVCL_0422 (MDCK) | CVCL_WY48 (MDCK-17) CVCL_ZW00 (MDCK-A3-10) CVCL_ZW01 (MDCK-A3-14)CVCL_ZV47 (MDCK-A3-15) CVCL_S586 (MDCK-MDR1) CVCL_X022 (MDCK-MRP2)CVCL_VR40 (MDCKII-LE) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK II; MDCKII; MDCK2; MDCK-2; MDCK Type II; MDCKII-WT | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Omics: Deep proteome analysis. | PubMed=1468552; DOI=10.1016/0014-5793(92)81476-3 Grunberg J., Luginbuhl U., Sterchi E.E. Proteolytic processing of human intestinal lactase-phlorizin hydrolase precursor is not a prerequisite for correct sorting in Madin Darby canine kidney (MDCK) cells. FEBS Lett. 314:224-228(1992) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=21766308; DOI=10.1002/jps.22674 Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y., Federico J.J. III, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D. Development of a new permeability assay using low-efflux MDCKII cells. J. Pharm. Sci. 100:4974-4985(2011) PubMed=21982418; DOI=10.1186/1471-2121-12-43 Dukes J.D., Whitley P., Chalmers A.D. The MDCK variety pack: choosing the right strain. BMC Cell Biol. 12:43-43(2011) PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045 Donis R.O., Chen I.-M., Davis C.T., Foust A., Hossain M.J., Johnson A., Klimov A., Loughlin R., Xu X., Tsai T., Blayer S., Trusheim H., Colegate T., Fox J., Taylor B., Hussain A., Barr I., Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen O., Neumeier E., Ziegler T. Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing. Vaccine 32:6583-6590(2014) | / |
MDCK.5F1 | CVCL_DE56 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | BV-5F1; BV5F1 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | / | PubMed=10494965 Percheson P.B., Trepanier P., Dugre R., Mabrouk T. A phase I, randomized controlled clinical trial to study the reactogenicity and immunogenicity of a new split influenza vaccine derived from a non-tumorigenic cell line. Dev. Biol. Stand. 98:127-132(1999) Patent=US20080254067 Trepanier P., Dugre R., Hassell T. Process for the production of an influenza vaccine. Patent number US20080254067, 16-Oct-2008 | / |
MDCK.STAT1 KO | CVCL_YZ44 | CVCL_0422 (MDCK) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | MDCK.STAT1KO | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Characteristics: Excellent cell model for virus propagation and viral vaccine production. It exhibits significant increased viral titer and enhanced virus production capability when compared to its parental cell line (ATCC). Doubling time: ~22 hours (ATCC). Knockout cell: Method=CRISPR/Cas9; UniProtKB; E2RI87; STAT1. | / | / |
MDCK.SUS1 | CVCL_WL70 | CVCL_0422 (MDCK) | CVCL_WL71 (MDCK.SUS2) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. Characteristics: Adapted to growth in suspension in SMIF8 medium. Doubling time: ~50 hours (PubMed=20638458). | PubMed=20638458; DOI=10.1016/j.vaccine.2010.07.004 Lohr V., Genzel Y., Behrendt I., Scharfenberg K., Reichl U. A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28:6256-6264(2010) | / |
MDCK.SUS2 | CVCL_WL71 | (CVCL_WL70) MDCK.SUS1 | CVCL_WL72 (MDCK.Xeno) | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Serum/protein free medium cell line. Characteristics: Adapted to growth in suspension in SMIF8 medium. Doubling time: 24 hours (in wave bioreactor), 37 hours (in stirred-tank reactor) (PubMed=20638458). | PubMed=20638458; DOI=10.1016/j.vaccine.2010.07.004 Lohr V., Genzel Y., Behrendt I., Scharfenberg K., Reichl U. A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28:6256-6264(2010) PubMed=25994255; DOI=10.1007/s00253-015-6636-8 Castro R., Fernandes P., Laske T., Sousa M.F.Q., Genzel Y., Scharfenberg K., Alves P.M., Coroadinha A.S. Production of canine adenovirus type 2 in serum-free suspension cultures of MDCK cells. Appl. Microbiol. Biotechnol. 99:7059-7068(2015) PubMed=31047676; DOI=10.1016/j.vaccine.2019.04.054 Bissinger T., Fritsch J., Mihut A., Wu Y.-X., Liu X.-P., Genzel Y., Tan W.-S., Reichl U. Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus production. Vaccine 37:7003-7010(2019) | / |
MDCK.Xeno | CVCL_WL72 | CVCL_WL71 (MDCK.SUS2) | / | pes domáci | Canis (lupus) familiaris | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | Group: Serum/protein free medium cell line. Characteristics: Adapted to growth in supsension in Xeno-S001S medium. Doubling time: <20 hours (PubMed=31047676). | PubMed=31047676; DOI=10.1016/j.vaccine.2019.04.054 Bissinger T., Fritsch J., Mihut A., Wu Y.-X., Liu X.-P., Genzel Y., Tan W.-S., Reichl U. Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus production. Vaccine 37:7003-7010(2019) | ||
MFF-8C1 | CVCL_1K31 | CVCL_R912 (MFF-1) | / | ostriež čínsky | Siniperca chuatsi | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | ikra | / | Group: Fish cell line. | PubMed=24101440; DOI=10.1007/s10616-013-9642-7 Dong C.-F., Shuang F., Weng S.-P., He J.-G. Cloning of a new fibroblast cell line from an early primary culture from mandarin fish (Siniperca chuatsi) fry for efficient proliferation of megalocytiviruses. Cytotechnology 66:883-890(2014) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) | / |
MRC-5 | CVCL_0440 | Áno | CVCL_2264 (1221) CVCL_2837 (A9(Neo1)) CVCL_2838 (A9(Neo11)) CVCL_2844 (A9(Neo19)) CVCL_2846 (A9(Neo20)) CVCL_2848 (A9(Neo4)) CVCL_WT86 (AG27415) CVCL_F664 (Flow13000) CVCL_JG29 (HuS-L12/10) CVCL_4W54 (HuSI-L23) CVCL_RG58 (iPSC D1) CVCL_RG59 (iPSC D4) CVCL_RB14 (IRR-MRC-5) CVCL_4W64 (L12.28-1/1) CVCL_U651 (L12.9-2(1)) CVCL_U661 (L23immo) CVCL_E260 (MRC-5 CV1) CVCL_2621 (MRC-5 pd13) CVCL_2622 (MRC-5 pd19) CVCL_2623 (MRC-5 pd25) CVCL_2624 (MRC-5 pd30) CVCL_JF54 (MRC-5 PDL12) CVCL_H749 (MRC-5 PDL27) CVCL_H748 (MRC-5 PDL40) CVCL_8B13 (MRC-5 PDL5.51) CVCL_2625 (MRC-5 SV1 TG1) CVCL_2626 (MRC-5 SV1 TG2) CVCL_3027 (MRC-5-30) CVCL_3028 (MRC-5-40) CVCL_3029 (MRC-5-50) CVCL_D690 (MRC-5V1) CVCL_2627 (MRC-5V2) CVCL_D923 (MRC-iPS-1) CVCL_D924 (MRC-iPS-10) CVCL_D925 (MRC-iPS-100) CVCL_D926 (MRC-iPS-101) CVCL_8343 (MRC-iPS-11) CVCL_D927 (MRC-iPS-12) CVCL_D928 (MRC-iPS-13) CVCL_D929 (MRC-iPS-14) CVCL_D930 (MRC-iPS-15) CVCL_D931 (MRC-iPS-16) CVCL_D932 (MRC-iPS-17) CVCL_8367 (MRC-iPS-18) CVCL_D933 (MRC-iPS-19) CVCL_D934 (MRC-iPS-2) CVCL_D935 (MRC-iPS-20) CVCL_D936 (MRC-iPS-21) CVCL_8426 (MRC-iPS-22) CVCL_D937 (MRC-iPS-23) CVCL_D938 (MRC-iPS-24) CVCL_8433 (MRC-iPS-25) CVCL_D939 (MRC-iPS-26) CVCL_8434 (MRC-iPS-27) CVCL_D940 (MRC-iPS-28) CVCL_D941 (MRC-iPS-29) CVCL_D942 (MRC-iPS-3) CVCL_D943 (MRC-iPS-30) CVCL_D944 (MRC-iPS-31) CVCL_D945 (MRC-iPS-32) CVCL_D946 (MRC-iPS-33) CVCL_D947 (MRC-iPS-34) CVCL_D948 (MRC-iPS-35) CVCL_D949 (MRC-iPS-36) CVCL_D950 (MRC-iPS-37) CVCL_D951 (MRC-iPS-38) CVCL_D952 (MRC-iPS-39) CVCL_D953 (MRC-iPS-4) CVCL_D954 (MRC-iPS-40) CVCL_D955 (MRC-iPS-41) CVCL_D956 (MRC-iPS-42) CVCL_D957 (MRC-iPS-43) CVCL_D958 (MRC-iPS-44) CVCL_D959 (MRC-iPS-45) CVCL_D960 (MRC-iPS-46) CVCL_D961 (MRC-iPS-47) CVCL_D962 (MRC-iPS-48) CVCL_D963 (MRC-iPS-49) CVCL_D964 (MRC-iPS-5) CVCL_D965 (MRC-iPS-50) CVCL_D966 (MRC-iPS-51) CVCL_D967 (MRC-iPS-52) CVCL_D968 (MRC-iPS-53) CVCL_D969 (MRC-iPS-54) CVCL_D970 (MRC-iPS-55) CVCL_D971 (MRC-iPS-56) CVCL_D972 (MRC-iPS-57) CVCL_D973 (MRC-iPS-58) CVCL_D974 (MRC-iPS-59) CVCL_D975 (MRC-iPS-6) CVCL_D976 (MRC-iPS-60) CVCL_D977 (MRC-iPS-61) CVCL_D978 (MRC-iPS-62) CVCL_D979 (MRC-iPS-63) CVCL_D980 (MRC-iPS-64) CVCL_D981 (MRC-iPS-65) CVCL_D982 (MRC-iPS-66) CVCL_D983 (MRC-iPS-67) CVCL_D984 (MRC-iPS-68) CVCL_D985 (MRC-iPS-69) CVCL_D986 (MRC-iPS-7) CVCL_D987 (MRC-iPS-70) CVCL_D988 (MRC-iPS-71) CVCL_D989 (MRC-iPS-72) CVCL_D990 (MRC-iPS-73) CVCL_D991 (MRC-iPS-74) CVCL_D992 (MRC-iPS-75) CVCL_D993 (MRC-iPS-76) CVCL_D994 (MRC-iPS-77) CVCL_D995 (MRC-iPS-78) CVCL_D996 (MRC-iPS-79) CVCL_D997 (MRC-iPS-8) CVCL_D998 (MRC-iPS-80) CVCL_D999 (MRC-iPS-81) CVCL_E000 (MRC-iPS-82) CVCL_E001 (MRC-iPS-83) CVCL_E002 (MRC-iPS-84) CVCL_E003 (MRC-iPS-85) CVCL_E004 (MRC-iPS-86) CVCL_E005 (MRC-iPS-87) CVCL_E006 (MRC-iPS-88) CVCL_E007 (MRC-iPS-89) CVCL_E008 (MRC-iPS-9) CVCL_E009 (MRC-iPS-90) CVCL_E010 (MRC-iPS-91) CVCL_E011 (MRC-iPS-92) CVCL_E012 (MRC-iPS-93) CVCL_E013 (MRC-iPS-94) CVCL_E014 (MRC-iPS-95) CVCL_E015 (MRC-iPS-96) CVCL_E016 (MRC-iPS-97) CVCL_E017 (MRC-iPS-98) CVCL_E018 (MRC-iPS-99) CVCL_C975 (MRC5-iPS12) CVCL_C974 (MRC5-iPS17) CVCL_V234 (MRC5-iPS2) CVCL_C976 (MRC5-RiPS-1.11) CVCL_C977 (MRC5-RiPS-1.2) CVCL_C978 (MRC5-RiPS-1.3) CVCL_C979 (MRC5-RiPS-1.8) CVCL_C980 (MRC5-RiPS-1.9) CVCL_Y625 (SR2) | človek | Homo sapiens | ľudská | neetická | MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | mužské | embryonálne | 14 fetálny týždeň | Biotechnology: Used for the production of the Human Diploid Cell Vaccine (HDCV) against rabies (Trade name: Imovax Rabies). Biotechnology: Used for the production of the Hepatitis A vaccines Avaxim, Epaxal, Havrix and Vaqta. Biotechnology: Used for the production of the live varicella virus vaccine (Trade name: Varivax). Biotechnology: Used for the production of the live zoster vaccine (Trade name: Zostavax). Characteristics: Senesces at 26 PDL (PubMed=17395773). Doubling time: ~34 hours (lot 06022011), ~1.5 days (lot 05202005), ~2 days (lot 05192003), 36 hours (lot 041392), ~5 days (lot 031098), ~38 hours (lot 04212016) (JCRB). Omics: DNA methylation analysis. Omics: Glycosphingolipids analysis. Omics: Proteome analysis by 2D-DE. Omics: Proteome analysis by 2D-DE/MS. Omics: Transcriptome analysis. Misspelling: MCR-5; Occasionally. | PubMed=4316953; DOI=10.1038/227168a0 Jacobs J.P., Jones C.M., Baille J.P. Characteristics of a human diploid cell designated MRC-5. Nature 227:168-170(1970) PubMed=932048; DOI=10.1016/0092-1157(76)90018-4 Jacobs J.P. The status of human diploid cell strain MRC-5 as an approved substrate for the production of viral vaccines. J. Biol. Stand. 4:97-99(1976) PubMed=1031681 Jacobs J.P. Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell strains. Dev. Biol. Stand. 37:155-156(1976) PubMed=211143 Friedman H.M., Koropchak C. Comparison of WI-38, MRC-5, and IMR-90 cell strains for isolation of viruses from clinical specimens. J. Clin. Microbiol. 7:368-371(1978) PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) PubMed=6538202; DOI=10.1083/jcb.98.3.1133 Azzarone B., Suarez H., Mingari M.-C., Moretta L., Fauci A.S. 4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin. J. Cell Biol. 98:1133-1137(1984) PubMed=3335022 Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589-601(1988) PubMed=1965304; DOI=10.1002/elps.1150111203 Celis J.E., Dejgaard K., Madsen P., Leffers H., Gesser B., Honore B., Rasmussen H.H., Olsen E., Lauridsen J.B., Ratz G., Mouritzen S., Basse B., Hellerup M., Celis A., Puype M., Van Damme J., Vandekerckhove J. The MRC-5 human embryonal lung fibroblast two-dimensional gel cellular protein database: quantitative identification of polypeptides whose relative abundance differs between quiescent, proliferating and SV40 transformed cells. Electrophoresis 11:1072-1113(1990) PubMed=10752125 Polianskaia G.G., Efremova T.N., Sakuta G.A. The effect of mycoplasmal contamination of human embryonic lung cell line MRC-5 on the karyotypic variability. Tsitologiia 42:190-195(2000) PubMed=17395773; DOI=10.1634/stemcells.2006-0504 Sudo K., Kanno M., Miharada K., Ogawa S., Hiroyama T., Saijo K., Nakamura Y. Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations. Stem Cells 25:1610-1617(2007) PubMed=19657000 Rubporn A., Srisomsap C., Subhasitanont P., Chokchaichamnankit D., Chiablaem K., Svasti J., Sangvanich P. Comparative proteomic analysis of lung cancer cell line and lung fibroblast cell line. Cancer Genomics Proteomics 6:229-237(2009) PubMed=21637780; DOI=10.1371/journal.pgen.1002085 Nishino K., Toyoda M., Yamazaki-Inoue M., Fukawatase Y., Chikazawa E., Sakaguchi H., Akutsu H., Umezawa A. DNA methylation dynamics in human induced pluripotent stem cells over time. PLoS Genet. 7:E1002085-E1002085(2011) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=26477663; DOI=10.1038/srep14988 Ojima T., Shibata E., Saito S., Toyoda M., Nakajima H., Yamazaki-Inoue M., Miyagawa Y., Kiyokawa N., Fujimoto J.I., Sato T., Umezawa A. Glycolipid dynamics in generation and differentiation of induced pluripotent stem cells. Sci. Rep. 5:14988-14988(2015) CLPUB00391 Wadman M. The vaccine race: science, politics, and the human costs of defeating disease. (In) ISBN 9780525427537; pp.1-436; Viking; New York (2016) | https://en.wikipedia.org/wiki/MRC-5 |
MRC-5 PDL12 | CVCL_JF54 | CVCL_0440 (MRC-5) | / | človek | Homo sapiens | ľudská | neetická | WHO MRC-5 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | mužské | embryonálne | 14 fetálny týždeň | / | / | http://www.who.int/biologicals/areas/vaccines/WHO_reference_cell_banks/en/ |
PBG.PK-21 | CVCL_WJ92 | / | / | diviak lesný | Sus scrofa | zvieracia | etická | PBG.PK2.1 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | / | neurčené | / | / | From: ProBioGen AG; Berlin; Germany. Characteristics: Free from porcine circovirus 1 (PCV1) infection. | PubMed=31005427; DOI=10.1016/j.vaccine.2019.04.030 Granicher G., Coronel J., Pralow A., Marichal-Gallardo P., Wolff M., Rapp E., Karlas A., Sandig V., Genzel Y., Reichl U. Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1. Vaccine 37:7019-7028(2019) | / |
PBS-1 | CVCL_1K16 | CVCL_Y589 (CHCC-OU2) | CVCL_1K17 (PBS-12SF) | kura bankivská | Gallus gallus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Bird cell line. | PubMed=18524432; DOI=10.1016/j.vaccine.2008.04.048 Smith K.A., Colvin C.J., Weber P.S.D., Spatz S.J., Coussens P.M. High titer growth of human and avian influenza viruses in an immortalized chick embryo cell line without the need for exogenous proteases. Vaccine 26:3778-3782(2008) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) DOI=10.4172/2157-7560.1000345 Sporer K.R.B., Carter J.L., Coussens P.M. The PBS-12SF cell line: development of an alternative cell line for influenza vaccine production. J. Vaccines Vaccin. 7:345-345(2016) | / |
PBS-12SF | CVCL_1K17 | CVCL_Y589 (CHCC-OU2) | CVCL_1K17 (PBS-12SF) | kura bankivská | Gallus gallus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Bird cell line. | PubMed=18524432; DOI=10.1016/j.vaccine.2008.04.048 Smith K.A., Colvin C.J., Weber P.S.D., Spatz S.J., Coussens P.M. High titer growth of human and avian influenza viruses in an immortalized chick embryo cell line without the need for exogenous proteases. Vaccine 26:3778-3782(2008) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) DOI=10.4172/2157-7560.1000345 Sporer K.R.B., Carter J.L., Coussens P.M. The PBS-12SF cell line: development of an alternative cell line for influenza vaccine production. J. Vaccines Vaccin. 7:345-345(2016) | / |
PER.C6 | CVCL_G704 | Áno | CVCL_A9E7 (HP PER.C6) | človek | Homo sapiens | ľudská | neetická | Per.C6; PER C6; PERC6; PerC6; Perc6; PER cell clone 6 | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B] | / | Transformované bunkové línie | očné | neurčené | embryonálne | / | From: Crucell (now part of Johnson & Johnson Janssen). Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 96022940. Biotechnology: Used for the production of follitropin delta (Trade name: Rekovelle). Misspelling: Per.Co6; Occasionally. Derived from sampling site: Eye; retina; retinoblast. Originate from same individual CVCL_1K15 ! 911 | PubMed=9741429; DOI=10.1089/hum.1998.9.13-1909 Fallaux F.J., Bout A., van der Velde I., van den Wollenberg D.J.M., Hehir K.M., Keegan J., Auger C., Cramer S.J., van Ormondt H., van der Eb A.J., Valerio D., Hoeben R.C. New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses. Hum. Gene Ther. 9:1909-1917(1998) PubMed=11257414; DOI=10.1016/S0264-410X(00)00508-9 Pau M.G., Ophorst C., Koldijk M.H., Schouten G., Mehtali M., Uytdehaag F. The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 19:2716-2721(2001) Patent=US6602706 Fallaux F.J., Hoeben R.C., van der Eb A.J., Bout A., Valerio D. Packaging systems for human recombinant adenovirus to be used in gene therapy. Patent number US6602706, 05-Aug-2003 PubMed=16566444 Lewis J.A., Brown E.L., Duncan P.A. Approaches to the release of a master cell bank of PER.C6 cells; a novel cell substrate for the manufacture of human vaccines. Dev. Biol. (Basel) 123:165-176(2006) PubMed=18052336; DOI=10.1021/bp070258u Berdichevsky M., Gentile M.P., Hughes B., Meis P., Peltier J., Blumentals I., Aunins J., Altaras N.E. Establishment of higher passage PER.C6 cells for adenovirus manufacture. Biotechnol. Prog. 24:158-165(2008) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) Patent=US9469865 Zijlstra G.M., Hof R.P., Schilder J. Process for the culturing of cells. Patent number US9469865, 18-Oct-2016 PubMed=28450423; DOI=10.1530/EC-17-0067 Koechling W., Plaksin D., Croston G.E., Jeppesen J.V., Macklon K.T., Andersen C.Y. Comparative pharmacology of a new recombinant FSH expressed by a human cell line. Endocr. Connect. 6:297-305(2017) | https://web.archive.org/web/20140721200546/http://www.crucell.com/page/downloads/Factsheet_PER.C6_Technology.pdf |
911 | CVCL_1K15 | / | / | človek | Homo sapiens | ľudská | neetická | HER;911; HER911; Human Embryonic Retinoblasts 911 | Pomocné bunkové línie | NCBI_TaxID; 28285; Adenovirus 5 [E1] | / | Transformované bunkové línie | očné | neurčené | embryonálne | / | Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 95062101. Derived from sampling site: Eye; retina; retinoblast. Originate from same individual CVCL_G704 ! PER.C6 | PubMed=8788172; DOI=10.1089/hum.1996.7.2-215 Fallaux F.J., Kranenburg O., Cramer S.J., Houweling A., van Ormondt H., Hoeben R.C., van der Eb A.J. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum. Gene Ther. 7:215-222(1996) Patent=US6602706 Fallaux F.J., Hoeben R.C., van der Eb A.J., Bout A., Valerio D. Packaging systems for human recombinant adenovirus to be used in gene therapy. Patent number US6602706, 05-Aug-2003 | / |
PK-15S | CVCL_YB14 | CVCL_2160 (PK-15) | / | diviak lesný | Sus scrofa | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | mužské | dospelé | / | Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-3307. | Patent=US20190300863 Jordan I., Sandig V., Horn D., John K. Novel porcine cell line for virus production. Patent number US20190300863, 03-Oct-2019 | / |
PT-80 | CVCL_4629 | / | / | tur domáci | Bos taurus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | obličkové | neurčené | / | / | / | PubMed=24000610 Bekhzadpur D., Belousova R.V., Ivanov I.V. Substantiation of optimum condition of parainfluenza-3 virus cultivation for production of vaccines on the finite cell line. Voen. Med. Zh. 334:27-31(2013) | / |
QN10S | CVCL_UG18 | CVCL_UG12 (AH927) | / | mačka domáca | Felis silvestris catus | zvieracia | etická | S+L- AH927 | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 11801; Moloney murine leukemia virus (MoMuLV) | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Derived from sampling site: Fibroblast. | PubMed=8825325; DOI=10.1136/vr.138.1.7 Jarrett O., Ganiere J.-P. Comparative studies of the efficacy of a recombinant feline leukaemia virus vaccine. Vet. Rec. 138:7-11(1996) PubMed=19122411; DOI=10.1292/jvms.70.1383 Sakaguchi S., Baba K., Ishikawa M., Yoshikawa R., Shojima T., Miyazawa T. Focus assay on RD114 virus in QN10S cells. J. Vet. Med. Sci. 70:1383-1386(2008) PubMed=21029758; DOI=10.1016/j.virusres.2010.10.020 Okada M., Yoshikawa R., Shojima T., Baba K., Miyazawa T. Susceptibility and production of a feline endogenous retrovirus (RD-114 virus) in various feline cell lines. Virus Res. 155:268-273(2011) | / |
QOR/2E11 | CVCL_1K18 | / | / | Prepelica virgínska | Colinus / Tetrao virginianus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCIt; C17231; Ultraviolet radiation | / | Transformované bunkové línie | / | neurčené | embryonálne | / | Group: Bird cell line. | PubMed=22373530; DOI=10.1186/1753-6561-5-S8-P52 Kraus B., von Fircks S., Feigl S., Koch S.M., Fleischanderl D., Terler K., Dersch-Pourmojib M., Konetschny C., Grillberger L., Reiter M. Avian cell line - technology for large scale vaccine production. BMC Proc. 5 Suppl. 8:P52-P52(2011) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) | / |
Sf9 | CVCL_0549 | CVCL_0518 (Sf21) | CVCL_1D71 (Sf-9ET) CVCL_JF76 (Sf-RVN) CVCL_JX36 (Sf9 TiterHigh AC free) CVCL_UF23 (sf9-ht33) CVCL_UF24 (sf9-ht35) CVCL_Z457 (Sf9-P35AcV5-1) CVCL_Z458 (Sf9-P35AcV5-3) CVCL_4U10 (Sf900+) CVCL_Z459 (Sf9S) CVCL_Z364 (Sfbeta4GalT) CVCL_Z454 (VE-CL-01) CVCL_Z455 (VE-CL-02) CVCL_Z456 (VE-CL-03) | červ armádny | Spodoptera frugiperda | zvieracia | etická | SF9; sf9; SF-9; Sf-9; sf-9; Sf 9; Spodoptera frugiperda clone 9; Sf clone 9; IPLB-Sf-9AE; IPLB-SF-9AE; IPLB-SF-9; IPLB-Sf-9; IPLB-Sf9 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | vaječníkové | ženské | kukla | / | Group: Insect cell line. Group: Recombinant protein production insect cell line. Group: Space-flown cell line (cellonaut). Doubling time: 27 hours (PubMed=21667340); ~50 hours (DSMZ). Karyotypic information: Heterogeneous, contains a mixture of diploid and tetraploid cells. Omics: ESTs sequenced. Omics: Transcriptome analysis. Omics: Genome sequenced. Anecdotal: Have been flown in space on shuttle flights STS-50 (USML-1), STS-54 and STS-57 (Spacehab-1) to study growth in microgravity (PubMed=8050503). Caution: The SfRV rhabdovirus found in Sf9 cells of ATCC CRL-1711 lot 5807852 (PubMed=24672045) does not seem to be expressed in CRL-1711 lot 5814 from 1987 (PubMed=28423032). The SfRV genome is integrated in the Sf9 genome. Derived from sampling site: Ovary. | PubMed=1367489; DOI=10.1021/bp00007a002 Hink W.F., Thomsen D.R., Davidson D.J., Meyer A.L., Castellino F.J. Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines. Biotechnol. Prog. 7:9-14(1991) PubMed=1369220; DOI=10.1021/bp00017a003 Wickham T.J., Davis T., Granados R.R., Shuler M.L., Wood H.A. Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnol. Prog. 8:391-396(1992) PubMed=8314732; DOI=10.1007/BF02633986 Davis T.R., Wickham T.J., McKenna K.A., Granados R.R., Shuler M.L., Wood H.A. Comparative recombinant protein production of eight insect cell lines. In Vitro Cell. Dev. Biol. Anim. 29:388-390(1993) PubMed=8050503; DOI=10.1006/excr.1994.1223 Moos P.J., Fattaey H.K., Johnson T.C. Cell proliferation inhibition in reduced gravity. Exp. Cell Res. 213:458-462(1994) PubMed=7615077; DOI=10.1016/0014-5793(95)00640-u Tremblay G.B., Sohi S.S., Retnakaran A., MacKenzie R.E. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is targeted to the cytoplasm in insect cell lines. FEBS Lett. 368:177-182(1995) PubMed=8799737; DOI=10.1111/j.1365-2583.1996.tb00053.x McIntosh A.H., Grasela J.J., Matteri R.L. Identification of insect cell lines by DNA amplification fingerprinting (DAF). Insect Mol. Biol. 5:187-195(1996) PubMed=10777062; DOI=10.1290/1071-2690(2000)036<0205:EOTGFP>2.0.CO;2 Grasela J.J., McIntosh A.H., Goodman C.L., Wilson L.E., King L.A. Expression of the green fluorescent protein carried by Autographa californica multiple nucleopolyhedrovirus in insect cell lines. In Vitro Cell. Dev. Biol. Anim. 36:205-210(2000) DOI=10.11416/jibs2001.71.25 Iwahori S., Ikeda M., Kobayashi M. Comparative characterization of pcna genes from Hyphantria cunea nucleopolyhedrovirus, and two cell lines from the fall armyworm, Spodoptera frugiperda, and the fall webworm, Hyphantria cunea. J. Insect Biotech. Sericol. 71:25-34(2002) PubMed=12052082; DOI=10.1021/bp020028 Jarman-Smith R.F., Armstrong S.J., Mannix C.J., Al-Rubeai M. Chromosome instability in Spodoptera frugiperda Sf-9 cell line. Biotechnol. Prog. 18:623-628(2002) PubMed=14668217; DOI=10.1093/bioinformatics/btg324 Landais I., Ogliastro M., Mita K., Nohata J., Lopez-Ferber M., Duonor-Cerutti M., Shimada T., Fournier P., Devauchelle G. Annotation pattern of ESTs from Spodoptera frugiperda Sf9 cells and analysis of the ribosomal protein genes reveal insect-specific features and unexpectedly low codon usage bias. Bioinformatics 19:2343-2350(2003) PubMed=19003226; DOI=10.1023/B:CYTO.0000043394.40309.48 Jarman-Smith R.F., Mannix C.J., Al-Rubeai M. Characterisation of tetraploid and diploid clones of Spodoptera frugiperda cell line. Cytotechnology 44:15-25(2004) PubMed=15926859; DOI=10.1290/0412081.1 Chen Y.P., Gundersen-Rindal D.E., Lynn D.E. Baculovirus-based expression of an insect viral protein in 12 different insect cell lines. In Vitro Cell. Dev. Biol. Anim. 41:43-49(2005) DOI=10.3923/jas.2007.4040.4043 Sadeq K.N.A., Yao H.-C., Peng J.-X. Identification of insect cell lines from 8 lepidopteran species by DNA amplification fingerprinting. J. Appl. Sci. 7:4040-4044(2007) DOI=10.1111/j.1439-0418.2010.01574.x Wu C.-Y., Lin H.-F., Wang C.-H., Lo C.-F. Identification of insect cell lines and cell-line cross-contaminations by nuclear ribosomal ITS sequences. J. Appl. Entomol. 135:601-610(2010) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=20300881; DOI=10.1007/s12033-010-9268-3 Krammer F., Schinko T., Palmberger D., Tauer C., Messner P., Grabherr R. Trichoplusia ni cells (High Five) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vaccines. Mol. Biotechnol. 45:226-234(2010) PubMed=21667340; DOI=10.1007/s12250-011-3177-x Wu Y.-L., Jiang L., Hashimoto Y., Granados R.R., Li G.-X. Establishment, growth kinetics, and susceptibility to AcMNPV of heat tolerant lepidopteran cell lines. Virol. Sin. 26:198-205(2011) PubMed=23891577; DOI=10.1016/j.tiv.2013.07.007 Curtis T.M., Collins A.M., Gerlach B.D., Brennan L.M., Widder M.W., van der Schalie W.H., Vo N.T.K., Bols N.C. Suitability of invertebrate and vertebrate cells in a portable impedance-based toxicity sensor: temperature mediated impacts on long-term survival. Toxicol. In Vitro 27:2061-2066(2013) PubMed=24375231; DOI=10.1007/s10529-013-1429-6 Wilde M., Klausberger M., Palmberger D., Ernst W., Grabherr R. Tnao38, high five and Sf9 -- evaluation of host-virus interactions in three different insect cell lines: baculovirus production and recombinant protein expression. Biotechnol. Lett. 36:743-749(2014) PubMed=24672045; DOI=10.1128/JVI.00780-14 Ma H., Galvin T.A., Glasner D.R., Shaheduzzaman S., Khan A.S. Identification of a novel rhabdovirus in Spodoptera frugiperda cell lines. J. Virol. 88:6576-6585(2014) PubMed=28423032; DOI=10.1371/journal.pone.0175633 Hashimoto Y., Macri D., Srivastava I., McPherson C., Felberbaum R., Post P., Cox M. Complete study demonstrating the absence of rhabdovirus in a distinct Sf9 cell line. PLoS ONE 12:E0175633-E0175633(2017) PubMed=28839023; DOI=10.1128/genomeA.00829-17 Nandakumar S., Ma H., Khan A.S. Whole-genome sequence of the Spodoptera frugiperda Sf9 insect cell line. Genome Announc. 5:e00829.17-e00829.17(2017) PubMed=29038528; DOI=10.1038/s41598-017-12713-9 Shu B.-S., Zhang J.-J., Sethuraman V., Cui G.-F., Yi X., Zhong G.-H. Transcriptome analysis of Spodoptera frugiperda Sf9 cells reveals putative apoptosis-related genes and a preliminary apoptosis mechanism induced by azadirachtin. Sci. Rep. 7:13231-13231(2017) PubMed=29133148; DOI=10.1016/j.pep.2017.11.002 Geisler C., Jarvis D.L. Adventitious viruses in insect cell lines used for recombinant protein expression. Protein Expr. Purif. 144:25-32(2017) | https://en.wikipedia.org/wiki/Sf9_(cells) |
SOgE | CVCL_Y592 | CVCL_3450 (QM7) | / | prepelica japonská | Coturnix coturnix japonica | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA) | / | Rakovinové bunkové línie | svalové | neurčené | dospelé | 1-3 týždne | Group: Bird cell line. | PubMed=12124462; DOI=10.1099/0022-1317-83-8-1987 Schumacher D., Tischer B.K., Teifke J.-P., Wink K., Osterrieder N. Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein E. J. Gen. Virol. 83:1987-1992(2002) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) | / |
ST-2014S | CVCL_XI68 | CVCL_2204 (ST [Pig testis]) | / | diviak lesný | Sus scrofa | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | semenníkové | mužské | embryonálne | 80-90 fetálnych dní | Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201567. Characteristics: Adapted to growth in suspension mode. | Patent=CN105112352B Li S.-Y., Xu S.-L., Wu H.-W., Xu G.-K. ST cell adapting to full-suspension culture, and application thereof, and vaccine virus culturing method. Patent number CN105112352B, 24-Jul-2018 | http://www.cellresource.cn/fdetail.aspx?id=2585 |
STS | CVCL_YB15 | CVCL_2204 (ST [Pig testis]) | / | diviak lesný | Sus scrofa | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | semenníkové | mužské | embryonálne | 80-90 fetálnych dní | Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-3308. | Patent=US20190300863 Jordan I., Sandig V., Horn D., John K. Novel porcine cell line for virus production. Patent number US20190300863, 03-Oct-2019 | / |
sVero p66 | CVCL_JX48 | CVCL_0574 (Vero C1008) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | sVero; Vero E6 AGS | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2791. Characteristics: Adapted to suspension growth in serum-free media. Doubling time: 24 hours (Patent=US20090203112). Derived from sampling site: Kidney; epithelium. | Patent=US20090203112 Daelli M.G., Forno G., Paillet P., Etcheverrigaray M., Kratje R. Vero cell line which is adapted to grow in suspension. Patent number US20090203112, 13-Aug-2009 PubMed=19559123; DOI=10.1016/j.vaccine.2009.06.020 Paillet C., Forno G., Kratje R., Etcheverrigaray M. Suspension-Vero cell cultures as a platform for viral vaccine production. Vaccine 27:6464-6467(2009) | / |
T17-17703A | CVCL_JF17 | CVCL_JF18 (DuckCelt-T17) | / | kačica pižmová | Cairina moschata | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A] | UniProtKB; B7S5K9; Cairina moschata TERT | Telomerázou imortalizované bunkové línie | / | neurčené | / | / | Group: Bird cell line. Group: Serum/protein free medium cell line. Group: Vaccine production cell line. From: Transgene SA; France. Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 09070703. Doubling time: 47 hours (Patent=US8513018). | Patent=US8513018 Erbs P., Kapfer M., Silvestre N. Immortalized avian cell lines. Patent number US8513018, 20-Aug-2013 | / |
T17-17703B | CVCL_JF15 | CVCL_JF18 (DuckCelt-T17) | / | kačica pižmová | Cairina moschata | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A] | UniProtKB; B7S5K9; Cairina moschata TERT | Telomerázou imortalizované bunkové línie | / | neurčené | / | / | Group: Bird cell line. Group: Serum/protein free medium cell line. From: Transgene SA; France. Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 09070701. Doubling time: 35 hours (Patent=US8513018). | Patent=US8513018 Erbs P., Kapfer M., Silvestre N. Immortalized avian cell lines. Patent number US8513018, 20-Aug-2013 | / |
T17-17703B2 | CVCL_JF16 | CVCL_JF18 (DuckCelt-T17) | / | kačica pižmová | Cairina moschata | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5 [E1A] | UniProtKB; B7S5K9; Cairina moschata TERT | Telomerázou imortalizované bunkové línie | / | neurčené | / | / | Group: Bird cell line. Group: Serum/protein free medium cell line. Group: Vaccine production cell line. From: Transgene SA; France. Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 09070702. Doubling time: 30 hours (Patent=US8513018). | Patent=US8513018 Erbs P., Kapfer M., Silvestre N. Immortalized avian cell lines. Patent number US8513018, 20-Aug-2013 | / |
Teth-CRFK | CVCL_WL54 | CVCL_2426 (CRFK) | / | mačka domáca | Felis silvestris catus | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | HGNC; 1119; BST2 | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | 3 mesiace | Characteristics: Has a reduced risk of RD-114 contamination by suppressing the release of infectious RD-114 from cells by the antiviral action of BST2/tetherin. Characteristics: Persistently infected by feline endogenous virus RD-114. | PubMed=23585909; DOI=10.1371/journal.pone.0061530 Fukuma A., Yoshikawa R., Miyazawa T., Yasuda J. A new approach to establish a cell line with reduced risk of endogenous retroviruses. PLoS ONE 8:E61530-E61530(2013) | / |
Vero | CVCL_0059 | Áno | CVCL_HA73 (BER-40) CVCL_4518 (ECTC) CVCL_WJ16 (SVP) CVCL_RW60 (VD60) CVCL_L035 (Vero 303) CVCL_0603 (Vero 76) CVCL_L036 (Vero F6) CVCL_EJ70 (Vero M) CVCL_RX68 (Vero Mx-Luc) CVCL_RX03 (Vero Mx13) CVCL_JF53 (Vero RCB 10-87) CVCL_1912 (Vero-B4) CVCL_ZX02 (Vero-CD4/CCR5) CVCL_4334 (Vero-Hektor) CVCL_ZW93 (Vero-pA104R) CVCL_1K11 (Vero-SF-ACF) CVCL_AS92 (Vero-SF-adapted) CVCL_GA12 (Vero-SV2neo clone VN5) CVCL_YZ45 (Vero.STAT1 KO) CVCL_L037 (Vero/hSLAM) CVCL_WC99 (VERO/IgR) CVCL_GA11 (Vero/PPRV H) CVCL_1K13 (Vero/SF) CVCL_YQ48 (Vero/TMPRSS2) CVCL_ZW77 (VeroS) CVCL_WL55 (VK219) CVCL_3807 (W162) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO; VeroCCL81; Vero 81; Verda reno | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Vaccine production cell line. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Biotechnology: Used for the production of the Japanese encephalitis virus (JEV) vaccine (Trade name: IXIARO/JESPECT). Biotechnology: Used for the production of the inactivated poliovirus vaccine (Trade name: Imovax Polio). Biotechnology: Used for the production of the Purified Vero-cell Rabies Vaccine (PVRV) (Trade name: VERORAB). Biotechnology: Used for the production of the Chromatographically Purified Rabies Vaccine (CPRV). Biotechnology: Used for the production of the live oral rotavirus vaccine (Trade Name: Rotarix). Biotechnology: Used for the production of the tetravalent dengue vaccine (Trade Name: Dengvaxia). Characteristics: Susceptible to SARS coronavirus (SARS-CoV) infection (PubMed=16494729). Characteristics: Susceptible to SARS coronavirus 2 (SARS-CoV-2) infection (COVID-19). But Vero C1008 (often known as Vero E6) (CVCL_0574) seems to be more appropriate for amplification and quantification (PubMed=32511316). Omics: Genome sequenced. Anecdotal: Verda reno means green kidney in Esperanto and Vero means truth also in Esperanto. | CLPUB00126 Yasumura Y., Kawakita Y. Studies on SV40 in tissue culture: preliminary step for cancer research in vitro. Nihon Rinsho 21:1201-1219(1963) PubMed=6027511; DOI=10.3181/00379727-125-32029 Simizu B., Rhim J.S., Wiebenga N.H. Characterization of the Tacaribe group of arboviruses. I. Propagation and plaque assay of Tacaribe virus in a line of African green monkey kidney cells (Vero). Proc. Soc. Exp. Biol. Med. 125:119-123(1967) PubMed=6298990; DOI=10.1016/0378-1135(82)90056-6 McPhee D.A., Parsonson I.M., Della-Porta A.J. Comparative studies on the growth of Australian bluetongue virus serotypes in continuous cell lines and embryonated chicken eggs. Vet. Microbiol. 7:401-410(1982) PubMed=4043530 Whitaker A.M., Hayward C.J. The characterization of three monkey kidney cell lines. Dev. Biol. Stand. 60:125-131(1985) CLPUB00328 Earley E., Johnson K. The lineage of Vero, Vero 76 and its clone C1008 in the United States. (In) Vero cells: origin, properties and biomedical applications; Simizu B., Terasima T. (eds.); pp.26-29; Department of Microbiology School of Medicine Chiba University; Chiba (1988) PubMed=10403033; DOI=10.1006/biol.1998.0156 Lang J., Cetre J.C., Picot N., Lanta M., Briantais P., Vital S., Le Mener V., Lutsch C., Rotivel Y. Immunogenicity and safety in adults of a new chromatographically purified Vero-cell rabies vaccine (CPRV): a randomized, double-blind trial with purified Vero-cell rabies vaccine (PVRV). Biologicals 26:299-308(1998) PubMed=10494966 Montagnon B.J., Vincent-Falquet J.-C., Saluzzo J.-F. Experience with Vero cells at Pasteur Merieux Connaught. Dev. Biol. Stand. 98:137-140(1999) PubMed=12667817; DOI=10.1016/S0042-6822(02)00064-8 Romanova J., Katinger D., Ferko B., Voglauer R., Mochalova L., Bovin N., Lim W., Katinger H., Egorov A. Distinct host range of influenza H3N2 virus isolates in Vero and MDCK cells is determined by cell specific glycosylation pattern. Virology 307:90-97(2003) PubMed=16494729; DOI=10.3201/eid1201.050496 Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J., Catton M., Birch C. SARS-associated coronavirus replication in cell lines. Emerg. Infect. Dis. 12:128-133(2006) DOI=10.12665/J63.Morgan Morgan J.H. Vero cells in vaccine production. BioProcess. J. 6:12-17(2007) PubMed=19016439; DOI=10.1002/9780471729259.mca04es11 Ammerman N.C., Beier-Sexton M., Azad A.F. Growth and maintenance of Vero cell lines. Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008) PubMed=19768803; DOI=10.1002/btpr.279 Rourou S., van der Ark A., van der Velden T., Kallel H. Development of an animal-component free medium for Vero cells culture. Biotechnol. Prog. 25:1752-1761(2009) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=22059503; DOI=10.1186/1472-6750-11-102 Almeida J.L., Hill C.R., Cole K.D. Authentication of African green monkey cell lines using human short tandem repeat markers. BMC Biotechnol. 11:102-102(2011) PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045 Donis R.O., Chen I.-M., Davis C.T., Foust A., Hossain M.J., Johnson A., Klimov A., Loughlin R., Xu X., Tsai T., Blayer S., Trusheim H., Colegate T., Fox J., Taylor B., Hussain A., Barr I., Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen O., Neumeier E., Ziegler T. Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing. Vaccine 32:6583-6590(2014) PubMed=25267831; DOI=10.1093/dnares/dsu029 Osada N., Kohara A., Yamaji T., Hirayama N., Kasai F., Sekizuka T., Kuroda M., Hanada K. The genome landscape of the African green monkey kidney-derived Vero cell line. DNA Res. 21:673-683(2014) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) PubMed=32511316; DOI=10.1101/2020.03.02.972935 Harcourt J., Tamin A., Lu X., Kamili S., Sakthivel S.K., Murray J., Queen K., Tao Y., Paden C.R., Zhang J., Li Y., Uehara A., Wang H., Goldsmith C., Bullock H.A., Wang L., Whitaker B., Lynch B., Gautam R., Schindewolf C., Lokugamage K.G., Scharton D., Plante J.A., Mirchandani D., Widen S.G., Narayanan K., Makino S., Ksiazek T.G., Plante K.S., Weaver S.C., Lindstrom S., Tong S., Menachery V.D., Thornburg N.J. Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient. bioRxiv 2020:972935-972935(2020) | https://en.wikipedia.org/wiki/Vero_cell |
Vero 303 | CVCL_L035 | CVCL_0059 (Vero) | CVCL_3863 (Vero 317) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. | / | / |
Vero 317 | CVCL_3863 | CVCL_L035 (Vero 303) | CVCL_T368 (Verots S3) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | Vero-317; Vero317 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. | / | / |
Vero 76 | CVCL_0603 | CVCL_0059 (Vero) | CVCL_0574 (Vero C1008) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO 76; Vero-76; VERO-76; VERO76; Vero76; Vero from pool #76 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. | CLPUB00328 Earley E., Johnson K. The lineage of Vero, Vero 76 and its clone C1008 in the United States. (In) Vero cells: origin, properties and biomedical applications; Simizu B., Terasima T. (eds.); pp.26-29; Department of Microbiology School of Medicine Chiba University; Chiba (1988) PubMed=19016439; DOI=10.1002/9780471729259.mca04es11 Ammerman N.C., Beier-Sexton M., Azad A.F. Growth and maintenance of Vero cell lines. Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008) PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 Karger A., Bettin B., Lenk M., Mettenleiter T.C. Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing. J. Virol. Methods 164:116-121(2010) PubMed=22059503; DOI=10.1186/1472-6750-11-102 Almeida J.L., Hill C.R., Cole K.D. Authentication of African green monkey cell lines using human short tandem repeat markers. BMC Biotechnol. 11:102-102(2011) PubMed=24973239; DOI=10.1099/vir.0.065995-0 Richter M., Reimann I., Schirrmeier H., Kirkland P.D., Beer M. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. J. Gen. Virol. 95:2216-2222(2014) | http://www.rccc.cytspb.rssi.ru/ecellbank/animal/avero_76.htm |
Vero C1008 | CVCL_0574 | CVCL_0603 (Vero 76) | CVCL_JX48 (sVero p66) CVCL_XD71 (Vero E6-S) CVCL_YZ66 (Vero E6/NPC1-KO cl.19)CVCL_YQ49 (VeroE6/TMPRSS2) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO C1008; VeroC1008; VEROC1008; VERO C 1008; Vero 76 clone E6; Vero 76 clone E-6; Vero E-6; Vero E6; VERO E6; Vero-E6; VeroE6 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Characteristics: Susceptible to infection by many viruses. Supports the growth of slowly replicating viruses (ATCC). Characteristics: Susceptible to SARS coronavirus (SARS-CoV) infection (PubMed=16494729). Characteristics: Susceptible to SARS coronavirus 2 (SARS-CoV-2) infection (COVID-19) (PubMed=32020029; PubMed=32511316). Doubling time: 22 hours (ATCC). | CLPUB00328 Earley E., Johnson K. The lineage of Vero, Vero 76 and its clone C1008 in the United States. (In) Vero cells: origin, properties and biomedical applications; Simizu B., Terasima T. (eds.); pp.26-29; Department of Microbiology School of Medicine Chiba University; Chiba (1988) PubMed=16494729; DOI=10.3201/eid1201.050496 Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J., Catton M., Birch C. SARS-associated coronavirus replication in cell lines. Emerg. Infect. Dis. 12:128-133(2006) PubMed=19016439; DOI=10.1002/9780471729259.mca04es11 Ammerman N.C., Beier-Sexton M., Azad A.F. Growth and maintenance of Vero cell lines. Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008) PubMed=32020029; DOI=10.1038/s41422-020-0282-0 Wang M.-L., Cao R.-Y., Zhang L.-K., Yang X.-L., Liu J., Xu M.-Y., Shi Z.-L., Hu Z.-H., Zhong W., Xiao G.-F. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30:269-271(2020) PubMed=32511316; DOI=10.1101/2020.03.02.972935 Harcourt J., Tamin A., Lu X., Kamili S., Sakthivel S.K., Murray J., Queen K., Tao Y., Paden C.R., Zhang J., Li Y., Uehara A., Wang H., Goldsmith C., Bullock H.A., Wang L., Whitaker B., Lynch B., Gautam R., Schindewolf C., Lokugamage K.G., Scharton D., Plante J.A., Mirchandani D., Widen S.G., Narayanan K., Makino S., Ksiazek T.G., Plante K.S., Weaver S.C., Lindstrom S., Tong S., Menachery V.D., Thornburg N.J. Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient. bioRxiv 2020:972935-972935(2020) | http://en.vircell.com/products/vero-e6-cell-line/ |
Vero E6-S | CVCL_XD71 | CVCL_0574 (Vero C1008) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C2017101. Characteristics: Adapted to suspension growth. | Patent=CN107267443A Li S.-Y., Xu S.-L. Vero E6 cell strain adapting to full-suspension culture and application thereof. Patent number CN107267443A, 20-Oct-2017 | http://www.cellresource.cn/fdetail.aspx?id=2954 |
Vero RCB 10-87 | CVCL_JF53 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | Vero (WHO); Vero(WHO); Vero-WHO; WHO Vero 10-87; 10-87 Vero | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Characteristics: A World Health Organisation (WHO) working cell bank of 1000 ampoules deposited at ECACC, derived from an original American Type Culture Collection (ATCC) ampoule. Available free of charge to organisations producing vaccines following receipt of approval to supply from WHO. | PubMed=10494966 Montagnon B.J., Vincent-Falquet J.-C., Saluzzo J.-F. Experience with Vero cells at Pasteur Merieux Connaught. Dev. Biol. Stand. 98:137-140(1999) DOI=10.12665/J63.Morgan Morgan J.H. Vero cells in vaccine production. BioProcess. J. 6:12-17(2007) PubMed=19016439; DOI=10.1002/9780471729259.mca04es11 Ammerman N.C., Beier-Sexton M., Azad A.F. Growth and maintenance of Vero cell lines. Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008) | http://www.who.int/biologicals/areas/vaccines/WHO_reference_cell_banks/en/ |
Vero-B4 | CVCL_1912 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO-B4; Vero B4; VeroB4 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Vaccine production cell line. Characteristics: Susceptible to infection by Middle East respiratory syndrome coronavirus (MERS-CoV) (PubMed=25531820). Doubling time: ~25 hours (DSMZ). | PubMed=25531820; DOI=10.3201/eid2101.141342 Meyer B., Garcia-Bocanegra I., Wernery U., Wernery R., Sieberg A., Muller M.A., Drexler J.F., Drosten C., Eckerle I. Serologic assessment of possibility for MERS-CoV infection in equids. Emerg. Infect. Dis. 21:181-182(2015) | / |
Vero-Hektor | CVCL_4334 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | Vero Hektor | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. | / | / |
Vero-pA104R | CVCL_ZW93 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | UniProtKB; P00552; Transposon Tn5 neo; UniProtKB; P68742; African swine fever virus (AFSV) isolate Ba71V pA104R. | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. | PubMed=31323824; DOI=10.3390/vaccines7030068 Freitas F.B., Simoes M., Frouco G., Martins C., Ferreira F. Towards the generation of an ASFV-pA104R DISC mutant and a complementary cell line -- a potential methodology for the production of a vaccine candidate. Vaccines (Basel). 7:68.1-68.16(2019) | / |
Vero-SF-ACF | CVCL_1K11 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | Vero-Serum Free-Animal Component Free | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. Characteristics: Adapted to serum-free and animal component-free medium. | / | / |
Vero-SF-adapted | CVCL_AS92 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO-SF | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. | / | / |
Vero.STAT1 KO | CVCL_YZ45 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Vaccine production cell line. Characteristics: Excellent cell model for virus propagation and viral vaccine production. It exhibits significant increased viral titer and enhanced virus production capability when compared to its parental cell line (ATCC). Doubling time: ~28 hours (ATCC). Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9RIE1; STAT1. | / | / |
Vero/SF | CVCL_1K13 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | VERO/SF | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. | / | / |
VeroS | CVCL_ZW77 | CVCL_0059 (Vero) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Characteristics: Adapted to suspension growth. | / | / |
Verots S3 | CVCL_T368 | CVCL_3863 (Vero 317) | CVCL_T369 (Verots S3(SF)) | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA58] | / | Transformované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. | PubMed=1368119; DOI=10.1007/BF00365927 Ohno T., Wang X., Kurashima J., Saijo-Kurita K., Hirono M. A novel Vero cell line for use as a mammalian host-vector system in serum-free medium. Cytotechnology 7:165-172(1991) | / |
Verots S3(SF) | CVCL_T369 | CVCL_T368 (Verots S3) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA58] | / | Transformované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Group: Serum/protein free medium cell line. | / | / |
Walvax-2 | CVCL_5J50 | Áno | / | človek | Homo sapiens | ľudská | neetická | WALVAX-2; WALVAX 2; Walvax 2; WALVAX2; Walvax2 | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | / | ženské | embryonálne | 3 fetálne mesiace | Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201055. Characteristics: Maintains excellent capabilities for growth and proliferation until PDL 50 (max PDL is 58). Doubling time: 39-41 hours (at 28th passage), 40-42 hours (at 38th passage), 57-62 hours (at 48th passage) (PubMed=25803132). Anecdotal: Is causing an outrage in some pro-lifer circles because it is a cell line originating from an aborted (for medical reasons) 3-month old female fetus. | Patent=CN102911910A Huang Z., He L.-F., Zhang W., Ma B., Wang L.-L., Zhao Q.-Y., Zhang Y., Wu W.-J., Chen M., Wang X., Tang Y.-F. Human embryo lung fibroblast strain and method for using human embryo lung fibroblast strain for producing hand-foot-mouth viral vaccine. Patent number CN102911910A, 06-Feb-2013 Patent=CN103525770B Ma B., Yang Z., He L.-F., Wang L.-L., Chen M., Wang X. Application of human fetal lung fibroblast line in preparation of hepatitis A vaccines. Patent number CN103525770B, 19-Aug-2015 PubMed=25803132; DOI=10.1080/21645515.2015.1009811 Ma B., He L.-F., Zhang Y.-L., Chen M., Wang L.-L., Yang H.-W., Yan T., Sun M.-X., Zheng C.-Y. Characteristics and viral propagation properties of a new human diploid cell line, Walvax-2, and its suitability as a candidate cell substrate for vaccine production. Hum. Vaccin. Immunother. 11:998-1009(2015) PubMed=26116706; DOI=10.1096/fj.14-266718 Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y. Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China. FASEB J. 29:4268-4272(2015) | http://www.cellresource.cn/fdetail.aspx?id=1875 |
WI-38 | CVCL_0579 | Áno | CVCL_1R80 (GM08854) CVCL_1R88 (GM10322) CVCL_1R89 (GM10323) CVCL_3142 (PSV811) CVCL_7871 (UTHs) CVCL_YU09 (WI-38 (HSV-2)Tr) CVCL_L281 (WI-38 CT-1) CVCL_5605 (WI-38 Tr) CVCL_2759 (WI-38 VA13 subline 2RA) CVCL_2812 (WI-38-30) CVCL_2813 (WI-38-40) CVCL_N806 (WI-38/hTERT/GFP-RAF-ER) | človek | Homo sapiens | ľudská | neetická | Wi-38; WI 38; WI38; Wistar Institute-38; AG06814-J; AG06814-M; AG06814-N | Bunková línia využívaná pri produkcii vakcín | / | / | Konečné bunkové línie | pľúcne | ženské | embryonálne | 16 fetálny týždeň | Group: Space-flown cell line (cellonaut). Group: Vaccine production cell line. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Biotechnology: Used for the production of RA27/3 - the first rubella virus vaccine. Biotechnology: Used for the production of live oral adenovirus type 4 and type 7 vaccine used by the US military. Produced first by Wyeth Laboratories from 1971 to 1999 and from 2011 onward by Barr Pharmaceuticals. Biotechnology: Was used in the early 1970's for the production of the Human Diploid Cell Vaccine (HDCV) vaccine against rabies by Institut Merieux. Characteristics: Used in many context such as senescence and aging studies. Characteristics: Life expectancy of 50 +- 10 population doublings. Characteristics: Senesces at 38 PDL (PubMed=17395773). Doubling time: ~24 hours (ATCC; ECACC). Omics: miRNA expression profiling. Omics: SNP array analysis. Omics: Transcriptome analysis. Anecdotal: Hayflick when numbering diploid cell strains 'jumped' directly from WI-27 (which failed) to WI-38 (CelloPub=CLPUB00391). Anecdotal: Have been flown in space on Skylab-3 to study growth in microgravity (PubMed=352912). | PubMed=14064953; DOI=10.1164/arrd.1963.88.3P2.387 Hayflick L. A comparison of primary monkey kidney, heteroploid cell lines, and human diploid cell strains for human virus vaccine preparation. Am. Rev. Respir. Dis. 88 Suppl. 3:387-393(1963) PubMed=14218592 Wiktor T.J., Fernandes M.V., Koprowski H. Cultivation of rabies virus in human diploid cell strain WI-38. J. Immunol. 93:353-366(1964) PubMed=5834207; DOI=10.1001/archpedi.1965.02090030401007 Plotkin S.A., Cornfeld D., Ingalls T.H. Studies of immunization with living rubella virus. Trials in children with a strain cultured from an aborted fetus. Am. J. Dis. Child. 110:381-389(1965) PubMed=14315085; DOI=10.1016/0014-4827(65)90211-9 Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614-636(1965) PubMed=5956336; DOI=10.1038/210100a0 Jacobs J.P. A simple medium for the propagation and maintenance of human diploid cell strains. Nature 210:100-101(1966) PubMed=5668122; DOI=10.3181/00379727-128-33119 Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R. Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms. Proc. Soc. Exp. Biol. Med. 128:772-776(1968) PubMed=5347639; DOI=10.1016/0014-4827(69)90166-9 Stanbridge E., Onen M., Perkins F.T., Hayflick L. Karyological and morphological characteristics of human diploid cell strain WI-38 infected with mycoplasmas. Exp. Cell Res. 57:397-410(1969) PubMed=4329447; DOI=10.1084/jem.133.3.454 Giraldo G., Beth E., Hirshaut Y., Aoki T., Old L.J., Boyse E.A., Chopra H.C. Human sarcomas in culture. Foci of altered cells and a common antigen; induction of foci and antigen in human fibroblast cultures by filtrates. J. Exp. Med. 133:454-478(1971) PubMed=4203458 Petricciani J.C., Wallace R.E., McCoy D.W. A comparison of three in vivo assays for cell tumorigenicity. Cancer Res. 34:105-108(1974) PubMed=4817727; DOI=10.1016/0014-4827(74)90416-9 Dell'Orco R.T., Mertens J.G., Kruse P.F. Jr. Doubling potential, calendar time, and donor age of human diploid cells in culture. Exp. Cell Res. 84:363-366(1974) PubMed=1031681 Jacobs J.P. Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell strains. Dev. Biol. Stand. 37:155-156(1976) PubMed=17792436; DOI=10.1126/science.192.4235.125 Wade N. Hayflick's tragedy: the rise and fall of a human cell line. Science 192:125-127(1976) PubMed=211143 Friedman H.M., Koropchak C. Comparison of WI-38, MRC-5, and IMR-90 cell strains for isolation of viruses from clinical specimens. J. Clin. Microbiol. 7:368-371(1978) PubMed=352912; DOI=10.1007/BF02618218 Montgomery P.O. Jr., Cook J.E., Reynolds R.C., Paul J.S., Hayflick L., Stock D., Schulz W.W., Kimsey S., Thirolf R.G., Rogers T., Campbell D. The response of single human cells to zero gravity. In Vitro 14:165-173(1978) PubMed=656543; DOI=10.1016/S0006-3495(78)85487-3 Ehmann U.K., Cook K.H., Friedberg E.C. The kinetics of thymine dimer excision in ultraviolet-irradiated human cells. Biophys. J. 22:249-264(1978) PubMed=699332; DOI=10.1016/0009-8981(78)90444-8 Knaup G., Pfleiderer G., Bayreuther K. Human diploid lung fibroblast cell lines WI 26 and WI 38 exhibit isozyme shift of alkaline phosphatase after viral transformation. Clin. Chim. Acta 88:375-383(1978) PubMed=535915; DOI=10.1007/BF02618249 Houghton B.A., Stidworthy G.H. A growth history comparison of the human diploid cells WI-38 and IMR-90: proliferative capacity and cell sizing analysis. In Vitro 15:697-702(1979) PubMed=6256643; DOI=10.1038/288724a0 Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature 288:724-727(1980) PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222 Hay R.J., Williams C.D., Macy M.L., Lavappa K.S. Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection. Am. Rev. Respir. Dis. 125:222-232(1982) PubMed=6409440; DOI=10.1093/carcin/4.7.911 Smith P.J., Greene M.H., Adams D., Paterson M.C. Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma. Carcinogenesis 4:911-916(1983) DOI=10.1016/B978-0-12-007903-2.50014-3 Hayflick L. The coming of age of WI-38. Adv. Cell Cult. 3:303-316(1984) PubMed=6538202; DOI=10.1083/jcb.98.3.1133 Azzarone B., Suarez H., Mingari M.-C., Moretta L., Fauci A.S. 4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin. J. Cell Biol. 98:1133-1137(1984) PubMed=7972006; DOI=10.1073/pnas.91.23.11045 Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B., Serrano M., Beach D.H., Harris C.C. Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994) DOI=10.11418/jtca1981.16.3_147 Hayflick L. The use of human cells for production of human biologicals. Tissue Cult. Res. Commun. 16:147-156(1997) PubMed=17395773; DOI=10.1634/stemcells.2006-0504 Sudo K., Kanno M., Miharada K., Ogawa S., Hiroyama T., Saijo K., Nakamura Y. Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations. Stem Cells 25:1610-1617(2007) PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013 Wilson P.F., Nham P.B., Urbin S.S., Hinz J.M., Jones I.M., Thompson L.H. Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. Mutat. Res. 683:91-97(2010) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=22984048; DOI=10.1126/science.337.6100.1292-a Hayflick L. Paying for tissue: the case of WI-38. Science 337:1292-1292(2012) DOI=10.1038/498407a Nature editorial staff A culture of consent. Nature 498:407-407(2013) DOI=10.1038/498422a Wadman M. Medical research: cell division. Nature 498:422-426(2013) PubMed=25063771; DOI=10.18632/aging.100679 Sidler C., Woycicki R., Kovalchuk I., Kovalchuk O. WI-38 senescence is associated with global and site-specific hypomethylation. Aging (Albany NY) 6:564-574(2014) PubMed=25903999; DOI=10.1002/biot.201400388 Genzel Y. Designing cell lines for viral vaccine production: where do we stand? Biotechnol. J. 10:728-740(2015) CLPUB00391 Wadman M. The vaccine race: science, politics, and the human costs of defeating disease. (In) ISBN 9780525427537; pp.1-436; Viking; New York (2016) | https://en.wikipedia.org/wiki/WI-38 |
VeroE6/TMPRSS2 | CVCL_YQ49 | CVCL_0574 (Vero C1008) | / | mačiak obecný (bielozelený) | Cercopithecus / Chlorocebus aethiops | zvieracia | etická | / | Bunková línia využívaná pri produkcii vakcín | / | HGNC; 11876; TMPRSS2; UniProtKB; P00552; Transposon Tn5 neo | Spontánne imortalizované bunkové línie | obličkové | ženské | dospelé | / | Group: Non-human primate cell line. Characteristics: Highly susceptible to Middle East respiratory syndrome coronavirus (MERS-CoV), SARS coronavirus (SARS-CoV) and SARS coronavirus 2 (SARS-CoV-2) infection (PubMed=32165541). | PubMed=31013314; DOI=10.1371/journal.pone.0215822 Nao N., Sato K., Yamagishi J., Tahara M., Nakatsu Y., Seki F., Katoh H., Ohnuma A., Shirogane Y., Hayashi M., Suzuki T., Kikuta H., Nishimura H., Takeda M. Consensus and variations in cell line specificity among human metapneumovirus strains. PLoS ONE 14:E0215822-E0215822(2019) PubMed=32165541; DOI=10.1073/pnas.2002589117 Matsuyama S., Nao N., Shirato K., Kawase M., Saito S., Takayama I., Nagata N., Sekizuka T., Katoh H., Kato F., Sakata M., Tahara M., Kutsuna S., Ohmagari N., Kuroda M., Suzuki T., Kageyama T., Takeda M. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proc. Natl. Acad. Sci. U.S.A. 117:7001-7003(2020) | / |
Caco-2 | CVCL_0025 | Áno | CVCL_1096 (C2BBe1) CVCL_Z582 (C2BBe2) CVCL_YP11 (Caco-2 Cu Pro-R) CVCL_YP12 (Caco-2 CuSO4-R) CVCL_HA82 (Caco-2-RCAr clone 2) CVCL_0232 (Caco-2/15) CVCL_Z578 (Caco-2/3) CVCL_Z579 (Caco-2/PD-10) CVCL_Z580 (Caco-2/PD-7) CVCL_Z581 (Caco-2/PF-11) CVCL_0233 (Caco-2/TC-7) | človek | Homo sapiens | ľudská | etická | CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II | Bunková línia využívaná pri produkcii vakcín | / | / | Rakovinové bunkové línie | črevný karcinóm | mužské | dospelé | 72 rokov | Part of: AstraZeneca Colorectal cell line (AZCL) panel. Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: ENCODE project common cell types; tier 3. Part of: MD Anderson Cell Lines Project. Characteristics: Highly permissive to SARS coronavirus (SARS-Cov) infection (PubMed=15316659). Doubling time: ~80 hours (DSMZ); ~32 hours (PBCF); ~60-70 hours (CLS). Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; PubMed=28683746). Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K27me3 ChIP-seq epigenome analysis. Omics: H3K36me3 ChIP-seq epigenome analysis. Omics: miRNA expression profiling. Omics: N-glycan profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. | PubMed=327080; DOI=10.1093/jnci/59.1.221 Fogh J., Fogh J.M., Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59:221-226(1977) PubMed=833871; DOI=10.1093/jnci/58.2.209 Fogh J., Wright W.C., Loveless J.D. Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J. Natl. Cancer Inst. 58:209-214(1977) PubMed=6935474; DOI=10.1093/jnci/66.2.239 Wright W.C., Daniels W.P., Fogh J. Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis. J. Natl. Cancer Inst. 66:239-247(1981) PubMed=7459858 Rousset M., Zweibaum A., Fogh J. Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins. Cancer Res. 41:1165-1170(1981) PubMed=3518877; DOI=10.3109/07357908609038260 Fogh J. Human tumor lines for cancer research. Cancer Invest. 4:157-184(1986) PubMed=3349466 Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A. Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines. Cancer Res. 48:1936-1942(1988) PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4 Hidalgo I.J., Raub T.J., Borchardt R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749(1989) PubMed=9294210; DOI=10.1073/pnas.94.19.10330 Ilyas M., Tomlinson I.P.M., Rowan A., Pignatelli M., Bodmer W.F. Beta-catenin mutations in cell lines established from human colorectal cancers. Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997) PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., Neumann T., Jauho A., Auer G., Ried T. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 27:183-190(2000) PubMed=10737795; DOI=10.1073/pnas.97.7.3352 Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M. APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'. Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000) PubMed=11414198; DOI=10.1007/s004320000207 Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J. Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J. Cancer Res. Clin. Oncol. 127:375-386(2001) PubMed=12584437; DOI=10.1159/000068544 Melcher R., Koehler S., Steinlein C., Schmid M., Mueller C.R., Luehrs H., Menzel T., Scheppach W., Moerk H., Scheurlen M., Koehrle J., Al-Taie O. Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway. Cytogenet. Genome Res. 98:22-28(2002) PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media. Toxicol. In Vitro 17:761-767(2003) PubMed=15316659; DOI=10.1007/s00018-004-4222-9 Cinatl J. Jr., Hoever G., Morgenstern B., Preiser W., Vogel J.-U., Hofmann W.-K., Bauer G., Michaelis M., Rabenau H.F., Doerr H.-W. Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. Cell. Mol. Life Sci. 61:2100-2112(2004) PubMed=15868485; DOI=10.1007/s10565-005-0085-6 Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 21:1-26(2005) PubMed=16418264; DOI=10.1073/pnas.0510146103 Liu Y., Bodmer W.F. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006) PubMed=16854228; DOI=10.1186/1476-4598-5-29 Bandres E., Cubedo E., Agirre X., Malumbres R., Zarate R., Ramirez N., Abajo A., Navarro A., Moreno I., Monzo M., Garcia-Foncillas J. Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol. Cancer 5:29-29(2006) PubMed=18258742; DOI=10.1073/pnas.0712176105 Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M. Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells. Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008) PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192 Janakiraman M., Vakiani E., Zeng Z., Pratilas C.A., Taylor B.S., Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C., Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B. Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Res. 70:5901-5911(2010) PubMed=20606684; DOI=10.1038/sj.bjc.6605780 Bracht K., Nicholls A.M., Liu Y., Bodmer W.F. 5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency. Br. J. Cancer 103:340-346(2010) PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x Ma Y.-L., Zhang P., Wang F., Moyer M.P., Yang J.-J., Liu Z.-H., Peng J.-Y., Chen H.-Q., Zhou Y.-K., Liu W.-J., Qin H.-L. Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b. J. Cell. Mol. Med. 15:1941-1954(2011) PubMed=21607810; DOI=10.1208/s12248-011-9283-8 Borchardt R.T. Hidalgo, I.J., Raub, T.J., and Borchardt, R.T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736-749, 1989 -- the backstory. AAPS J. 13:323-327(2011) PubMed=23272949; DOI=10.1186/1755-8794-5-66 Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med. Genomics 5:66-66(2012) PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032 Salendo J., Spitzner M., Kramer F., Zhang X., Jo P., Wolff H.A., Kitz J., Kaulfuss S., Beissbarth T., Dobbelstein M., Ghadimi M., Grade M., Gaedcke J. Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g. Radiother. Oncol. 108:451-457(2013) PubMed=24042735; DOI=10.1038/oncsis.2013.35 Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M., Hektoen M., Lind G.E., Lothe R.A. Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis 2:E71-E71(2013) PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013 Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 74:3238-3247(2014) PubMed=25960936; DOI=10.4161/21624011.2014.954893 Boegel S., Lower M., Bukur T., Sahin U., Castle J.C. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. OncoImmunology 3:E954893-E954893(2014) PubMed=25485619; DOI=10.1038/nbt.3080 Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 33:306-312(2015) PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019 Piersma S.R., Knol J.C., de Reus I., Labots M., Sampadi B.K., Pham T.V., Ishihama Y., Verheul H.M.W., Jimenez C.R. Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines. J. Proteomics 127:247-258(2015) PubMed=25926053; DOI=10.1038/ncomms8002 Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A. The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. Nat. Commun. 6:7002-7002(2015) PubMed=26537799; DOI=10.1074/mcp.M115.051235 Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., Tollenaar R.A., Rombouts Y., Wuhrer M. N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression. Mol. Cell. Proteomics 15:124-140(2016) PubMed=26869432; DOI=10.1016/j.xphs.2015.10.030 Olander M., Wisniewski J.R., Matsson P., Lundquist P., Artursson P. The proteome of filter-grown Caco-2 cells with a focus on proteins involved in drug disposition. J. Pharm. Sci. 105:817-827(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=28683746; DOI=10.1186/s12943-017-0691-y Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J., Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E., Myklebost O., Skotheim R.I., Sveen A., Lothe R.A. Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies. Mol. Cancer 16:116-116(2017) PubMed=29101300; DOI=10.15252/msb.20177701 Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B. Pharmacoproteomic characterisation of human colon and rectal cancer. Mol. Syst. Biol. 13:951-951(2017) PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019) PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019) PubMed=31981602; DOI=10.1016/j.tiv.2020.104773 O'Doherty C., Keenan J., Henry M., Meleady P., Sinkunaite I., Clynes M., O'Sullivan F., Horgan K., Murphy R. Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line. Toxicol. In Vitro 65:104773-104773(2020) | https://en.wikipedia.org/wiki/Caco-2 |
Calu-3 | CVCL_0609 | Áno | CVCL_YZ47 (Calu-3 2B4) CVCL_EQ19 (Calu3-GemR) | človek | Homo sapiens | ľudská | etická | CaLu-3; CALU-3; Calu 3; Calu3; CALU3 | Bunková línia využívaná pri produkcii vakcín | / | / | Rakovinové bunkové línie | pľúcny kacinóm | mužské | dospelé | 25 rokov | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-533. Doubling time: 35 hours (in RPMI 1640 + 10% FBS), 45 hours (in ACL-3), 37 hours (in ACL-3+BSA) (PubMed=3940644); 40.1 hours (PubMed=29681454). Microsatellite instability: Stable (MSS) (Sanger). Omics: Cell surface proteome. Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. Misspelling: CALV3; In Cosmic 1434969. | PubMed=327080; DOI=10.1093/jnci/59.1.221 Fogh J., Fogh J.M., Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59:221-226(1977) PubMed=7459858 Rousset M., Zweibaum A., Fogh J. Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins. Cancer Res. 41:1165-1170(1981) PubMed=6220172 Dracopoli N.C., Fogh J. Polymorphic enzyme analysis of cultured human tumor cell lines. J. Natl. Cancer Inst. 70:469-476(1983) PubMed=3518877; DOI=10.3109/07357908609038260 Fogh J. Human tumor lines for cancer research. Cancer Invest. 4:157-184(1986) PubMed=3940644 Brower M., Carney D.N., Oie H.K., Gazdar A.F., Minna J.D. Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Cancer Res. 46:798-806(1986) PubMed=3129183 Hubbard W.C., Alley M.C., McLemore T.L., Boyd M.R. Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas. Cancer Res. 48:2674-2677(1988) PubMed=3335022 Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589-601(1988) PubMed=7515578; DOI=10.1152/ajplung.1994.266.5.L493 Shen B.Q., Finkbeiner W.E., Wine J.J., Mrsny R.J., Widdicombe J.H. Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion. Am. J. Physiol. 266:L493-L501(1994) PubMed=9636188; DOI=10.1073/pnas.95.13.7556 Kaplan D.H., Shankaran V., Dighe A.S., Stockert E., Aguet M., Old L.J., Schreiber R.D. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 95:7556-7561(1998) PubMed=10523844; DOI=10.1038/sj.onc.1202957 Agochiya M., Brunton V.G., Owens D.W., Parkinson E.K., Paraskeva C., Keith W.N., Frame M.C. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 18:5646-5653(1999) PubMed=11064206; DOI=10.1016/S0378-5173(00)00452-X Foster K.A., Avery M.L., Yazdanian M., Audus K.L. Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Int. J. Pharm. 208:1-11(2000) PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Gruenert D.C., Willems M., Cassiman J.J., Frizzell R.A. Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004) PubMed=17483357; DOI=10.1158/0008-5472.CAN-06-4495 Tooker P., Yen W.-C., Ng S.-C., Negro-Vilar A., Hermann T.W. Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res. 67:4425-4433(2007) PubMed=18083107; DOI=10.1016/j.cell.2007.11.025 Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-1203(2007) PubMed=19472407; DOI=10.1002/humu.21028 Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M. A gene-alteration profile of human lung cancer cell lines. Hum. Mutat. 30:1199-1206(2009) PubMed=20090954; DOI=10.1371/journal.pone.0008729 Yoshikawa T., Hill T.E., Yoshikawa N., Popov V.L., Galindo C.L., Garner H.R., Peters C.J., Tseng C.-T. Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection. PLoS ONE 5:E8729-E8729(2010) PubMed=20164919; DOI=10.1038/nature08768 Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R. Signatures of mutation and selection in the cancer genome. Nature 463:893-898(2010) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=22460905; DOI=10.1038/nature11003 Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483:603-607(2012) PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112 Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov. 2:798-811(2012) PubMed=24207061; DOI=10.1186/1559-0275-10-16 Cerciello F., Choi M., Nicastri A., Bausch-Fluck D., Ziegler A., Vitek O., Felley-Bosco E., Stahel R.A., Aebersold R., Wollscheid B. Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring. Clin. Proteomics 10:16-16(2013) PubMed=25485619; DOI=10.1038/nbt.3080 Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 33:306-312(2015) PubMed=25555374; DOI=10.1016/j.ejps.2014.12.017 Kreft M.E., Jerman U.D., Lasic E., Hevir-Kene N., Rizner T.L., Peternel L., Kristan K. The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function. Eur. J. Pharm. Sci. 69:1-9(2015) PubMed=25894527; DOI=10.1371/journal.pone.0121314 Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B. A mass spectrometric-derived cell surface protein atlas. PLoS ONE 10:E0121314-E0121314(2015) PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J. A landscape of pharmacogenomic interactions in cancer. Cell 166:740-754(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=29681454; DOI=10.1016/j.cell.2018.03.028 McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A., Gibbs R.A., Hwang T.-H., Heymach J.V., Wistuba I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., Deberardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A. Chemistry-first approach for nomination of personalized treatment in lung cancer. Cell 173:864-878.e29(2018) PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019) PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019) | https://en.wikipedia.org/wiki/Calu-3 |
HEK293T | CVCL_0063 | CVCL_0045 (HEK293) | CVCL_JZ09 (293LTV) CVCL_JZ10 (293RTV) CVCL_UE53 (293T cyno BCMA) CVCL_UE54 (293T cyno CCR6) CVCL_UE55 (293T cyno CD123) CVCL_UE56 (293T cyno CD137) CVCL_XY80 (293T cyno CD40) CVCL_XY81 (293T cyno CSF1R) CVCL_UE58 (293T cyno DLL3) CVCL_XY82 (293T cyno GITR) CVCL_UE57 (293T cyno LAG3) CVCL_UE59 (293T cyno OX40) CVCL_XY83 (293T cyno PDL1) CVCL_XY84 (293T dog CSF1R) CVCL_XY85 (293T dog GITR) CVCL_0V13 (293T GNE) CVCL_UE34 (293T human B7H4) CVCL_UE35 (293T human BCMA) CVCL_UE36 (293T human CCR6) CVCL_UC03 (293T human CD123) CVCL_UE19 (293T human CD133) CVCL_UE20 (293T human CD137) CVCL_XY87 (293T human CD137L) CVCL_UE21 (293T human CD138) CVCL_UE22 (293T human CD154(CD40L)) CVCL_UE23 (293T human CD22) CVCL_XY88 (293T human CD25) CVCL_UE24 (293T human CD33) CVCL_UE25 (293T human CD40) CVCL_XY89 (293T human CD47) CVCL_UC04 (293T human CLDN18.1) CVCL_XY90 (293T human CLDN18.1-Flag) CVCL_UE18 (293T human CLDN18.2) CVCL_XY91 (293T human CLDN18.2-M4) CVCL_XY86 (293T human CSF1R) CVCL_UE37 (293T human CTLA4) CVCL_UE38 (293T human DLL3) CVCL_UE93 (293T human EGFR vIII) CVCL_UE39 (293T human Epcam) CVCL_UE40 (293T human FOLH1) CVCL_UE41 (293T human GPC3) CVCL_UE42 (293T human LAG3) CVCL_UE43 (293T human NRP1) CVCL_UE44 (293T human OX40) CVCL_UE45 (293T human OX40L) CVCL_UE46 (293T human PD-1) CVCL_UE47 (293T human PDL1) CVCL_UE48 (293T human PDL2) CVCL_XY92 (293T human PVR) CVCL_UE49 (293T human ROR1) CVCL_UE50 (293T human TIGIT) CVCL_UE51 (293T human TIM3) CVCL_UE52 (293T human TROP2) CVCL_UE60 (293T mouse CCR6) CVCL_UE61 (293T mouse CLDN18.2) CVCL_XY93 (293T mouse CSF1R) CVCL_XY94 (293T mouse GITR) CVCL_XY95 (293T NF-kb luciferase reporter) CVCL_UE94 (293T OS8) CVCL_UE95 (293T OS8-hB7H4) CVCL_UE96 (293T OS8-hPDL1) CVCL_RU09 (293T R-Spondin1 expressing) CVCL_XY96 (293T rabbit CSF1R) CVCL_XY97 (293T rat CSF1R) CVCL_XY98 (293T rat GITR) CVCL_1H20 (293T-CEP4SIVtat) CVCL_LC70 (293T-S) CVCL_YZ65 (293T/ACE2) CVCL_W645 (293T/APOBEC3G) CVCL_H376 (293T/AT1) CVCL_JZ02 (293T/GFP-Puro) CVCL_KS35 (293T/NFkB-luc) CVCL_H377 (293T/NMU2) CVCL_LC69 (293T/pAPtag-4) CVCL_BT05 (293Ta) CVCL_AR71 (293TGPRT+R1) CVCL_9705 (293TsiLL) CVCL_1D85 (293TT) CVCL_0P39 (5H7) CVCL_VT57 (BPKU) CVCL_KS65 (CellSensor AP1-bla HEK 293T) CVCL_KS67 (CellSensor c-fos-bla HEK 293T) CVCL_KS57 (CellSensor CRE-bla HEK 293T) CVCL_KS62 (CellSensor ISRE-bla HEK 293T) CVCL_KB26 (CellSensor NFAT-bla HEK 293T) CVCL_KS61 (CellSensor NFkB-bla HEK 293T) CVCL_KS17 (CellSensor SBE-bla HEK 293T) CVCL_KS27 (CellSensor SIE-bla HEK 293T) CVCL_LF40 (GeneBLAzer UAS-bla HEK 293T) CVCL_RU08 (HA-R-Spondin1-Fc 293T) CVCL_RW32 (Hana3A) CVCL_4U22 (HEK-SC-293T) CVCL_ZM06 (HEK293T Control-PEROXO) CVCL_WN31 (HEK293T G6PD p.Gly131Val) CVCL_VR11 (HEK293T GALE KO clone 4) CVCL_VR12 (HEK293T GALK1 KO clone 10) CVCL_VR13 (HEK293T GALK2 KO clone 7) CVCL_YM16 (HEK293T GAPDH-KD) CVCL_ZM07 (HEK1293T HA-PEROXO) CVCL_QZ51 (HEK293T shPARG) CVCL_ZC45 (HEK293T SIRT1 KO) CVCL_QW54 (HEK293T SMARCB1-/-) CVCL_HA71 (HEK293T(DMT1)) CVCL_1926 (HEK293T/17) CVCL_1H36 (HZ-293TS) CVCL_YA24 (IDG-HEK293T-CACNA2D4-V5-OE) CVCL_YA25 (IDG-HEK293T-CACNB1-V5-OE) CVCL_YA26 (IDG-HEK293T-CACNB2-V5-OE) CVCL_YA27 (IDG-HEK293T-CACNB4-V5-OE) CVCL_YA28 (IDG-HEK293T-CACNG1-V5-OE) CVCL_YA29 (IDG-HEK293T-CACNG3-V5-OE) CVCL_YA30 (IDG-HEK293T-CACNG5-V5-OE) CVCL_YA31 (IDG-HEK293T-CACNG7-V5-OE) CVCL_YA32 (IDG-HEK293T-CACNG8-V5-OE) CVCL_YA44 (IDG-HEK293T-CALHM4-V5-OE) CVCL_YA33 (IDG-HEK293T-CATSPER2-V5-OE) CVCL_YA34 (IDG-HEK293T-CHRNA10-V5-OE) CVCL_YA35 (IDG-HEK293T-CHRNA2-V5-OE) CVCL_YA36 (IDG-HEK293T-CHRNB1-V5-OE) CVCL_YA37 (IDG-HEK293T-CHRND-V5-OE) CVCL_YA38 (IDG-HEK293T-CLCA4-V5-OE) CVCL_YA39 (IDG-HEK293T-CLCN6-V5-OE) CVCL_YA40 (IDG-HEK293T-CLCNKA-V5-OE) CVCL_YA41 (IDG-HEK293T-CLIC2-V5-OE) CVCL_YA42 (IDG-HEK293T-CLIC5-V5-OE) CVCL_YA43 (IDG-HEK293T-CNGA4-V5-OE) CVCL_YA45 (IDG-HEK293T-FXYD3-V5-OE) CVCL_YA46 (IDG-HEK293T-FXYD7-V5-OE) CVCL_YA47 (IDG-HEK293T-GABRA5-V5-OE) CVCL_YA48 (IDG-HEK293T-GABRG1-V5-OE) CVCL_YA49 (IDG-HEK293T-GABRP-V5-OE) CVCL_YA50 (IDG-HEK293T-GABRR1-V5-OE) CVCL_YA51 (IDG-HEK293T-GLRA3-V5-OE) CVCL_YA52 (IDG-HEK293T-GRID1-isoform-1-V5-OE) CVCL_YA53 (IDG-HEK293T-GRID1-isoform-2-V5-OE) CVCL_YA54 (IDG-HEK293T-HTR3C-V5-OE) CVCL_YA55 (IDG-HEK293T-HTR3D-V5-OE) CVCL_YA56 (IDG-HEK293T-HTR3E-V5-OE) CVCL_YA57 (IDG-HEK293T-KCNA6-V5-OE) CVCL_YA58 (IDG-HEK293T-KCNA7-V5-OE) CVCL_YA59 (IDG-HEK293T-KCNAB2-V5-OE) CVCL_YA60 (IDG-HEK293T-KCNAB3-V5-OE) CVCL_YA61 (IDG-HEK293T-KCNG4-V5-OE) CVCL_YA62 (IDG-HEK293T-KCNIP1-V5-OE) CVCL_YA63 (IDG-HEK293T-KCNIP4-V5-OE) CVCL_YA64 (IDG-HEK293T-KCNJ14-V5-OE) CVCL_YA65 (IDG-HEK293T-KCNJ15-V5-OE) CVCL_YA66 (IDG-HEK293T-KCNK12-V5-OE) CVCL_YA67 (IDG-HEK293T-KCNK4-V5-OE) CVCL_YA68 (IDG-HEK293T-KCNK7-V5-OE) CVCL_YA69 (IDG-HEK293T-KCNS1-V5-OE) CVCL_YA70 (IDG-HEK293T-KCNS2-V5-OE) CVCL_YA71 (IDG-HEK293T-KCNS3-V5-OE) CVCL_YA73 (IDG-HEK293T-LRRC55-V5-OE) CVCL_YA74 (IDG-HEK293T-PANX2-V5-OE) CVCL_YA75 (IDG-HEK293T-PKD1L2-V5-OE) CVCL_YA76 (IDG-HEK293T-PKD2L2-V5-OE) CVCL_YA77 (IDG-HEK293T-PLLP-V5-OE) CVCL_YA78 (IDG-HEK293T-SCN2B-V5-OE) CVCL_YA79 (IDG-HEK293T-SCNN1B-V5-OE) CVCL_YA80 (IDG-HEK293T-SCNN1D-V5-OE) CVCL_YA81 (IDG-HEK293T-TMC4-V5-OE) CVCL_YA82 (IDG-HEK293T-TMEM63A-V5-OE) CVCL_YA83 (IDG-HEK293T-TMEM63B-V5-OE) CVCL_YA84 (IDG-HEK293T-TMEM63C-V5-OE) CVCL_YA85 (IDG-HEK293T-TTYH2-V5-OE) CVCL_YZ81 (LentiPro26) CVCL_KS48 (MultiScreen HEK293T mGluR2) CVCL_KS49 (MultiScreen HEK293T mGluR4) CVCL_RN04 (PDIS-1) CVCL_RN05 (PDIS-12) CVCL_RN07 (PDIS-2) CVCL_RN08 (PDIS-22) CVCL_H716 (Phoenix-Ampho) CVCL_H717 (Phoenix-Eco) CVCL_H718 (Phoenix-gp) CVCL_B489 (Plat-A) CVCL_B488 (Plat-E) CVCL_B490 (Plat-GP) CVCL_ZU61 (RIG-I(-/-) 293T) CVCL_AR73 (STAR) CVCL_DA04 (Tau RD P301S FRET Biosensor) | človek | Homo sapiens | ľudská | neetická | Hek293T; HEK-293T; HEK 293T; HEK-293-T; HEK 293 T; 293-T; 293 T; 293T; Human Embryonic Kidney 293T; 293tsA1609neo | Bunková línia využívaná pri produkcii vakcín | NCBI_TaxID; 28285; Adenovirus 5; NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA] | UniProtKB; P00552; Transposon Tn5 neo | Transformované bunkové línie | obličkové | ženské | embryonálne | / | Part of: ENCODE project common cell types; tier 3. Part of: MD Anderson Cell Lines Project. Doubling time: ~24-30 hours (DSMZ). Transfected with: UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 28285; Adenovirus 5. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA]. Omics: Deep proteome analysis. Omics: Genome sequenced. Omics: miRNA expression profiling. Omics: Protein expression by reverse-phase protein arrays. Misspelling: HECK293T; Occasionally. Misspelling: HEK239T; Occasionally. | PubMed=3031469; DOI=10.1128/MCB.7.1.379 DuBridge R.B., Tang P., Hsia H.C., Leong P.-M., Miller J.H., Calos M.P. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 7:379-387(1987) PubMed=15900046; DOI=10.1093/jnci/dji133 Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J. Natl. Cancer Inst. 97:765-777(2005) PubMed=25182477; DOI=10.1038/ncomms5767 Lin Y.-C., Boone M., Meuris L., Lemmens I., Van Roy N., Soete A., Reumers J., Moisse M., Plaisance S., Drmanac R., Chen J., Speleman F., Lambrechts D., Van de Peer Y., Tavernier J., Callewaert N. Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations. Nat. Commun. 5:4767-4767(2014) PubMed=26694163; DOI=10.1371/journal.pone.0144924 Janiszewska J., Szaumkessel M., Kostrzewska-Poczekaj M., Bednarek K., Paczkowska J., Jackowska J., Grenman R., Szyfter K., Wierzbicka M., Giefing M., Jarmuz-Szymczak M. Global miRNA expression profiling identifies miR-1290 as novel potential oncomiR in laryngeal carcinoma. PLoS ONE 10:E0144924-E0144924(2015) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=28601559; DOI=10.1016/j.cels.2017.05.009 Bekker-Jensen D.B., Kelstrup C.D., Batth T.S., Larsen S.C., Haldrup C., Bramsen J.B., Sorensen K.D., Hoyer S., Orntoft T.F., Andersen C.L., Nielsen M.L., Olsen J.V. An optimized shotgun strategy for the rapid generation of comprehensive human proteomes. Cell Syst. 4:587-599.e4(2017) DOI=10.13005/bpj/1414 Yuan J., Xu W.W.-W., Jiang S.Y.-L., Yu H.X.-Y., Poon H.-F. The scattered twelve tribes of HEK293. Biomed. Pharmacol. J. 11:621-623(2018) | http://genome.ucsc.edu/ENCODE/protocols/cell/human/HEK293T_Crawford_protocol.pdf |
Huh-7 | CVCL_0336 | Áno | CVCL_U442 (B76/Huh7) CVCL_RW46 (HG23) CVCL_X943 (Huh-5-2) CVCL_ZW90 (HuH-7-END) CVCL_JG51 (Huh-7-Luc) CVCL_U459 (Huh-7-Lunet) CVCL_7927 (Huh-7.5) CVCL_WJ09 (Huh-7/F24) CVCL_XE85 (Huh-7/M8) CVCL_2957 (Huh-7D12) CVCL_LG22 (HuH-7T1) CVCL_UZ56 (Huh7 IFITM2-/-) CVCL_HA62 (HUH7-ins) CVCL_4W53 (Huh7S1) CVCL_VN30 (OR6 [Human]) | človek | Homo sapiens | ľudská | etická | HuH-7; HUH-7; HuH7; Huh7; HUH7; HUH7.0; JTC-39; Japanese Tissue Culture-39 | Bunková línia využívaná pri produkcii vakcín | / | / | Rakovinové bunkové línie | pečeňový karcinóm | mužské | dospelé | 57 rokov | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 3. Part of: JFCR45 cancer cell line panel. Part of: Liver Cancer Model Repository (LIMORE). Part of: MD Anderson Cell Lines Project. Part of: TCGA-110-CL cell line panel. Population: Japanese. Doubling time: 32.2 hours (PubMed=31378681); ~48 hours (CLS). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Genome sequenced. Omics: miRNA expression profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis. | PubMed=6203805; DOI=10.20772/cancersci1959.75.2_151 Nakabayashi H., Taketa K., Yamane T., Miyazaki M., Miyano K., Sato J. Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Gann 75:151-158(1984) DOI=10.1007/978-4-431-68349-0_4 Alexander J.J. Human hepatoma cell lines. (In) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo (1987) DOI=10.11418/jtca1981.12.3_221 Namba M., Nakabayashi H., Doi I., Sato J., Miyazaki M. Cellular characteristics and utilization of human hepatoma cell lines which were established in our laboratory and distributed by Japanese Cancer Research Resources Bank. Tissue Cult. Res. Commun. 12:221-227(1993) PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613 Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E., Ponchel F., Yakicier C., Ji J., Ozturk M. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J. 7:1407-1413(1993) PubMed=8389256; DOI=10.1093/carcin/14.5.987 Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C. p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 14:987-992(1993) PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A Tsuboi S., Nagamori S., Miyazaki M., Mihara K., Fukaya K., Teruya K., Kosaka T., Tsuji T., Namba M. Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines. J. Med. Virol. 48:133-140(1996) DOI=10.11418/jtca1981.16.3_173 Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ohashi R., Namba M. The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory. Tissue Cult. Res. Commun. 16:173-178(1997) PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog. 19:243-253(1997) PubMed=9359923; DOI=10.18926/AMO/30789 Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ishioka C., Namba M. Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory. Acta Med. Okayama 51:261-265(1997) PubMed=10523694; DOI=10.3892/or.6.6.1267 Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M. Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma. Oncol. Rep. 6:1267-1271(1999) PubMed=12029633; DOI=10.1053/jhep.2002.33683 Yasui K., Arii S., Zhao C., Imoto I., Ueda M., Nagai H., Emi M., Inazawa J. TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology 35:1476-1484(2002) PubMed=15708988; DOI=10.1128/JVI.79.5.2689-2699.2005 Sumpter R. Jr., Loo Y.-M., Foy E., Li K., Yoneyama M., Fujita T., Lemon S.M., Gale M. Jr. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J. Virol. 79:2689-2699(2005) PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234 Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T. Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays. Mol. Cancer Ther. 4:399-412(2005) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=22460905; DOI=10.1038/nature11003 Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483:603-607(2012) PubMed=23285155; DOI=10.1371/journal.pone.0052697 Murayama A., Sugiyama N., Yoshimura S., Ishihara-Sugano M., Masaki T., Kim S., Wakita T., Mishiro S., Kato T. A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest. PLoS ONE 7:E52697-E52697(2012) PubMed=23505090; DOI=10.1002/hep.26402 Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J. Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma. Hepatology 58:706-717(2013) PubMed=23887712; DOI=10.1038/ncomms3218 Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat. Commun. 4:2218-2218(2013) PubMed=24973239; DOI=10.1099/vir.0.065995-0 Richter M., Reimann I., Schirrmeier H., Kirkland P.D., Beer M. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus. J. Gen. Virol. 95:2216-2222(2014) PubMed=25485619; DOI=10.1038/nbt.3080 Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 33:306-312(2015) PubMed=25574106; DOI=10.3748/wjg.v21.i1.311 Cevik D., Yildiz G., Ozturk M. Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations. World J. Gastroenterol. 21:311-317(2015) PubMed=27329724; DOI=10.18632/oncotarget.10161 Watari K., Nishitani A., Shibata T., Noda M., Kawahara A., Akiba J., Murakami Y., Yano H., Kuwano M., Ono M. Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma. Oncotarget 7:47403-47417(2016) PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J. A landscape of pharmacogenomic interactions in cancer. Cell 166:740-754(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=29610054; DOI=10.1016/j.dmpk.2018.03.003 Shi J., Wang X., Lyu L., Jiang H., Zhu H.-J. Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes. Drug Metab. Pharmacokinet. 33:133-140(2018) PubMed=29774518; DOI=10.1007/s13577-018-0212-3 Kasai F., Hirayama N., Ozawa M., Satoh M., Kohara A. HuH-7 reference genome profile: complex karyotype composed of massive loss of heterozygosity. Hum. Cell 31:261-267(2018) PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019) PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001 Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S. Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response. Gastroenterology 157:760-776(2019) PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019) PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001 Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J. A pharmacogenomic landscape in human liver cancers. Cancer Cell 36:179-193.e11(2019) PubMed=31395879; DOI=10.1038/s41467-019-11415-2 Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M. Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. Nat. Commun. 10:3574-3574(2019) DOI=10.1101/2020.02.17.953281 Kawamoto M., Yamaji T., Saito K., Satomura K., Endo T., Fukasawa M., Hanada K., Osada N. Identification of characteristic genomic markers in human hepatoma Huh7 and Huh7.5.1-8 cell lines. bioRxiv 2020:953281-953281(2020) PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P. Quantitative proteomics of the Cancer Cell Line Encyclopedia. Cell 180:387-402.e16(2020) PubMed=32899426; DOI=10.3390/cancers12092510 Scherer D., Davila Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Bermejo J.L. RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling. Cancers (Basel) 12:2510.1-2510.14(2020) | https://en.wikipedia.org/wiki/Huh7 |
LLC-MK2 | CVCL_3009 | Áno | CVCL_U988 (NCTC 3196) CVCL_3069 (NCTC 3526) | makak rhesus | Macaca mulatta | zvieracia | etická | Llc-Mk2; LLC-MK-2; LLCMK2; LLcMK2; Lilly Laboratories Cell-Monkey Kidney 2 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | obličkové | neučené | dospelé | / | Group: Non-human primate cell line. Characteristics: Derived from the trypsinization of a pool of kidneys from 6 adult rhesus monkeys. Characteristics: Susceptible to SARS coronavirus (SARS-CoV) infection (PubMed=16494729). | PubMed=13821019; DOI=10.1093/oxfordjournals.aje.a120078 Evans V.J., Kerr H.A., McQuilkin W.T., Earle W.R., Hull R.N. Growth in vitro of a long-term strain of monkey-kidney cells in medium NCTC 109 free of any added protein. Am. J. Hyg. 70:297-302(1959) PubMed=14449901; DOI=10.1084/jem.115.5.903 Hull R.N., Cherry W.R., Tritch O.J. Growth characteristics of monkey kidney cell strains LLC-MK1, LLC-MK2, and LLC-MK2(NCTC-3196) and their utility in virus research. J. Exp. Med. 115:903-918(1962) PubMed=14185313; DOI=10.1126/science.146.3641.241 Cell Culture Collection Committee Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells. Science 146:241-243(1964) PubMed=18605421; DOI=10.1093/jnci/45.5.951 Ikeuchi T., Sandberg A.A. Chromosome pulverization in virus-induced heterokaryons of mammalian cells from different species. J. Natl. Cancer Inst. 45:951-963(1970) PubMed=4203458 Petricciani J.C., Wallace R.E., McCoy D.W. A comparison of three in vivo assays for cell tumorigenicity. Cancer Res. 34:105-108(1974) PubMed=6298990; DOI=10.1016/0378-1135(82)90056-6 McPhee D.A., Parsonson I.M., Della-Porta A.J. Comparative studies on the growth of Australian bluetongue virus serotypes in continuous cell lines and embryonated chicken eggs. Vet. Microbiol. 7:401-410(1982) PubMed=16494729; DOI=10.3201/eid1201.050496 Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J., Catton M., Birch C. SARS-associated coronavirus replication in cell lines. Emerg. Infect. Dis. 12:128-133(2006) | http://fluoview.magnet.fsu.edu/gallery/cells/llcmk2/llcmk2cells.html |
Efk3B | CVCL_GZ34 | / | / | netopier hnedý | Eptesicus / Vespertilio fuscus | zvieracia | etická | EFK3B; Efk-3B; Efk3 clone 3B; Eptesicus fuscus kidney 3B | Bunková línia využívaná pri produkcii vakcín | Myotis polyomavirus large T-antigen (MyPVTag) | / | Transformované bunkové línie | obličkové | mužské | / | / | Group: Bat cell line. Characteristics: Can be used to cultivate viruses from the Coronaviridae, Filoviridae, Herpesviridae, Paramyxoviridae and Rhabdoviridae. Doubling time: 24 hours (Kerafast). Transformant: Myotis polyomavirus large T-antigen (MyPVTag). | PubMed=27639955; DOI=10.1016/j.jviromet.2016.09.008 Banerjee A., Rapin N., Miller M., Griebel P., Zhou Y., Munster V.J., Misra V. Generation and characterization of Eptesicus fuscus (Big brown bat) kidney cell lines immortalized using the Myotis polyomavirus large T-antigen. J. Virol. Methods 237:166-173(2016) | http://usask.technologypublisher.com/tech/Eptesicus_fuscus_(Big_Brown_Bat)_kidney_immortalized_cell_line |
CHO-K1 | CVCL_0214 | CVCL_0213 (CHO) | CVCL_8544 (AR-EcoScreen) CVCL_J386 (C54) CVCL_J387 (C55.7) CVCL_KU72 (cAMP Hunter CHO-K1 ADCYAP1R1 Gs/Gq) CVCL_KU73 (cAMP Hunter CHO-K1 ADORA1 Gi) CVCL_KU74 (cAMP Hunter CHO-K1 ADORA2B Gs) CVCL_KU75 (cAMP Hunter CHO-K1 ADORA3 Gi) CVCL_KU76 (cAMP Hunter CHO-K1 ADRA2A Gi) CVCL_KU77 (cAMP Hunter CHO-K1 ADRA2C Gi) CVCL_KU78 (cAMP Hunter CHO-K1 ADRB1 Gs) CVCL_KU79 (cAMP Hunter CHO-K1 ADRB2 Gs) CVCL_KU80 (cAMP Hunter CHO-K1 AGTRL1 Gi) CVCL_KU81 (cAMP Hunter CHO-K1 AVPR2 Gs) CVCL_KU82 (cAMP Hunter CHO-K1 C3AR1 Gi) CVCL_KU83 (cAMP Hunter CHO-K1 C5AR1 Gi) CVCL_KU84 (cAMP Hunter CHO-K1 CALCR Gs) CVCL_KU85 (cAMP Hunter CHO-K1 CALCRL-RAMP1 Gs) CVCL_KU86 (cAMP Hunter CHO-K1 CALCRL-RAMP3 Gs) CVCL_KU87 (cAMP Hunter CHO-K1 CCR1 Gi) CVCL_KU88 (cAMP Hunter CHO-K1 CCR10 Gi) CVCL_KU89 (cAMP Hunter CHO-K1 CCR5 Gi) CVCL_KU90 (cAMP Hunter CHO-K1 CCR6 Gi) CVCL_KU91 (cAMP Hunter CHO-K1 CCR7 Gi) CVCL_KU92 (cAMP Hunter CHO-K1 CHRM2 Gs) CVCL_KU93 (cAMP Hunter CHO-K1 CHRM4 Gs) CVCL_KU94 (cAMP Hunter CHO-K1 CMKLR1 Gi) CVCL_KU95 (cAMP Hunter CHO-K1 CNR1 Gi) CVCL_KU96 (cAMP Hunter CHO-K1 CNR2 Gi) CVCL_KU97 (cAMP Hunter CHO-K1 CRHR1 Gs) CVCL_KU98 (cAMP Hunter CHO-K1 CRHR2 Gs) CVCL_KU99 (cAMP Hunter CHO-K1 CRTH2 Gi) CVCL_KV00 (cAMP Hunter CHO-K1 CXCR1 Gi) CVCL_KV01 (cAMP Hunter CHO-K1 CXCR2 Gi) CVCL_KV02 (cAMP Hunter CHO-K1 CXCR3 Gi) CVCL_KV03 (cAMP Hunter CHO-K1 CXCR4 Gi) CVCL_KV04 (cAMP Hunter CHO-K1 CXCR5 Gi) CVCL_KV05 (cAMP Hunter CHO-K1 CXCR6 Gi) CVCL_KV06 (cAMP Hunter CHO-K1 DRD1 Gs) CVCL_KV07 (cAMP Hunter CHO-K1 DRD2L Gi) CVCL_KV08 (cAMP Hunter CHO-K1 DRD2S Gi) CVCL_KV09 (cAMP Hunter CHO-K1 DRD4 Gi) CVCL_KV10 (cAMP Hunter CHO-K1 DRD5 Gs) CVCL_KV11 (cAMP Hunter CHO-K1 EBI2 Gi) CVCL_KV12 (cAMP Hunter CHO-K1 EDG1 Gi) CVCL_KV13 (cAMP Hunter CHO-K1 EDG2 Gi) CVCL_KV14 (cAMP Hunter CHO-K1 FFAR3 Gi) CVCL_KV15 (cAMP Hunter CHO-K1 FPR1 Gi) CVCL_KV16 (cAMP Hunter CHO-K1 FPR3 Gi) CVCL_KV17 (cAMP Hunter CHO-K1 FPRL1 Gi) CVCL_KV18 (cAMP Hunter CHO-K1 FSHR Gs) CVCL_KV19 (cAMP Hunter CHO-K1 GABBR1-GABBR2 Gi) CVCL_KV20 (cAMP Hunter CHO-K1 GALR1 Gi) CVCL_KV21 (cAMP Hunter CHO-K1 GCGR Gs) CVCL_KV22 (cAMP Hunter CHO-K1 GHRHR Gs) CVCL_KV23 (cAMP Hunter CHO-K1 GIPR Gs) CVCL_KV24 (cAMP Hunter CHO-K1 GLP1R Gs) CVCL_KV25 (cAMP Hunter CHO-K1 GLP2R Gs) CVCL_KV26 (cAMP Hunter CHO-K1 GPBAR1 Gs) CVCL_KV27 (cAMP Hunter CHO-K1 GPR109A Gi) CVCL_KV28 (cAMP Hunter CHO-K1 GPR109B Gi) CVCL_KV29 (cAMP Hunter CHO-K1 GPR35 Gi) CVCL_KV30 (cAMP Hunter CHO-K1 GPR81 Gi) CVCL_KV31 (cAMP Hunter CHO-K1 GPR84 Gi) CVCL_KV32 (cAMP Hunter CHO-K1 GRM2 Gi) CVCL_KV33 (cAMP Hunter CHO-K1 GRM3 Gi) CVCL_KV34 (cAMP Hunter CHO-K1 GRM4 Gi) CVCL_KV35 (cAMP Hunter CHO-K1 GRM6 Gi) CVCL_KV36 (cAMP Hunter CHO-K1 HRH2 Gs/Gq) CVCL_KV37 (cAMP Hunter CHO-K1 HRH3 Gi) CVCL_KV38 (cAMP Hunter CHO-K1 HTR1A Gi) CVCL_KV39 (cAMP Hunter CHO-K1 HTR1B Gi) CVCL_KV40 (cAMP Hunter CHO-K1 HTR1F Gi) CVCL_KV41 (cAMP Hunter CHO-K1 HTR5A Gi) CVCL_KV42 (cAMP Hunter CHO-K1 HTR7A Gs) CVCL_KV43 (cAMP Hunter CHO-K1 LHCGR Gs) CVCL_KV44 (cAMP Hunter CHO-K1 LTB4R Gi) CVCL_KV45 (cAMP Hunter CHO-K1 MC1R Gs) CVCL_KV46 (cAMP Hunter CHO-K1 MC3R Gs) CVCL_KV47 (cAMP Hunter CHO-K1 MC4R Gs) CVCL_KV48 (cAMP Hunter CHO-K1 MC5R Gs) CVCL_KV49 (cAMP Hunter CHO-K1 MCHR1 Gi) CVCL_KV50 (cAMP Hunter CHO-K1 mGIPR Gs) CVCL_KV51 (cAMP Hunter CHO-K1 mRXFP1 Gs) CVCL_KV52 (cAMP Hunter CHO-K1 mTAAR1 Gs) CVCL_KV53 (cAMP Hunter CHO-K1 MTNR1A Gi) CVCL_KV54 (cAMP Hunter CHO-K1 MTNR1B Gi) CVCL_KV55 (cAMP Hunter CHO-K1 NPBWR1 Gi) CVCL_KV56 (cAMP Hunter CHO-K1 NPBWR2 Gi) CVCL_KV57 (cAMP Hunter CHO-K1 NPFFR1 Gi) CVCL_KV58 (cAMP Hunter CHO-K1 NPY2R Gi) CVCL_KV59 (cAMP Hunter CHO-K1 OPRD1 Gi) CVCL_KV60 (cAMP Hunter CHO-K1 OPRK1 Gi) CVCL_KV61 (cAMP Hunter CHO-K1 OPRL1 Gi) CVCL_KV62 (cAMP Hunter CHO-K1 OPRM1 Gi) CVCL_KV63 (cAMP Hunter CHO-K1 OXER1 Gi) CVCL_KV64 (cAMP Hunter CHO-K1 PPYR1 Gi) CVCL_KV65 (cAMP Hunter CHO-K1 PROKR1 Gs) CVCL_KV66 (cAMP Hunter CHO-K1 PTAFR Gi) CVCL_KV67 (cAMP Hunter CHO-K1 PTGDR Gs) CVCL_KV68 (cAMP Hunter CHO-K1 PTGER3 Gi) CVCL_KV69 (cAMP Hunter CHO-K1 PTGIR Gs) CVCL_KV70 (cAMP Hunter CHO-K1 PTHR1 Gs/Gq) CVCL_KV71 (cAMP Hunter CHO-K1 PTHR2 Gs/Gq) CVCL_KV72 (cAMP Hunter CHO-K1 rDRD1 Gs) CVCL_KV73 (cAMP Hunter CHO-K1 rDRD2L Gi) CVCL_KV74 (cAMP Hunter CHO-K1 rDRD2S Gi) CVCL_KV75 (cAMP Hunter CHO-K1 rTAAR1 Gs) CVCL_KV76 (cAMP Hunter CHO-K1 RXFP1 Gs) CVCL_KV77 (cAMP Hunter CHO-K1 RXFP2 Gs) CVCL_KV78 (cAMP Hunter CHO-K1 RXFP3 Gi) CVCL_KV79 (cAMP Hunter CHO-K1 RXFP4 Gi) CVCL_KV80 (cAMP Hunter CHO-K1 SCTR Gs) CVCL_KV81 (cAMP Hunter CHO-K1 SSTR2 Gi) CVCL_KV82 (cAMP Hunter CHO-K1 SSTR3 Gi) CVCL_KV83 (cAMP Hunter CHO-K1 SSTR4 Gi) CVCL_KV84 (cAMP Hunter CHO-K1 SSTR5 Gi) CVCL_KV85 (cAMP Hunter CHO-K1 TAAR1 Gs) CVCL_KV86 (cAMP Hunter CHO-K1 TACR3 Gs/Gq) CVCL_KV87 (cAMP Hunter CHO-K1 TSHR(L) Gs) CVCL_KV88 (cAMP Hunter CHO-K1 VIPR1 Gs/Gq) CVCL_KV89 (cAMP Hunter CHO-K1 VIPR2 Gs) CVCL_KV90 (cAMP Hunter CHO-K1 XCR1 Gi) CVCL_KR97 (CellSensor CRE-bla CHO-K1) CVCL_KB29 (CellSensor NFAT-bla CHO-K1) CVCL_AZ68 (CHO 13-5-1) CVCL_AZ69 (CHO 14-2-1) CVCL_VU04 (CHO 15B) CVCL_4V31 (CHO 15DACT) CVCL_JL49 (CHO 1C T6) CVCL_GX98 (CHO 22H11) CVCL_U429 (CHO 25-RA) CVCL_K254 (CHO 4364) CVCL_HC66 (CHO 7PA2) CVCL_HC65 (CHO 7WD10) CVCL_1N32 (CHO Ade-A) CVCL_1N33 (CHO Ade-B) CVCL_1N34 (CHO Ade-C) CVCL_1N35 (CHO Ade-D) CVCL_1N36 (CHO Ade-E) CVCL_1N37 (CHO Ade-F) CVCL_1N38 (CHO Ade-G) CVCL_1N39 (CHO Ade-H) CVCL_1N40 (CHO Ade-I) CVCL_1N41 (CHO Ade-PAB) CVCL_UZ04 (CHO Ade-PcG) CVCL_UZ89 (CHO BLMR-1) CVCL_UZ90 (CHO BLMR-2) CVCL_UZ91 (CHO BLMR-3) CVCL_UZ92 (CHO BLMR-4) CVCL_DR98 (CHO CAT-S) CVCL_GP77 (CHO CERT) CVCL_RW58 (CHO DRA10) CVCL_9Y69 (CHO HcD6) CVCL_1Y10 (CHO JR-FL gp160 (Clone A19)) CVCL_1H27 (CHO NL4-3 gp120) CVCL_1G49 (CHO NL4-3 gp160) CVCL_1Y08 (CHO PBj gp130) CVCL_UZ06 (CHO SH-87) CVCL_W649 (CHO ST4.2) CVCL_V348 (CHO Tet-On 3G) CVCL_GP78 (CHO XBP1s) CVCL_U217 (CHO(pMAM-HSluc)) CVCL_U218 (CHO(pMAM-luc)) CVCL_V326 (CHO-22) CVCL_XD05 (CHO-5-HT1B) CVCL_4700 (CHO-6) CVCL_D893 (CHO-7) CVCL_V327 (CHO-91) CVCL_V328 (CHO-91-22) CVCL_V329 (CHO-91-22-47-67) CVCL_V330 (CHO-91-47-67) CVCL_H340 (CHO-A7) CVCL_DE19 (CHO-AT3-2) CVCL_VR93 (CHO-CH3S) CVCL_U002 (CHO-CHRM1) CVCL_U003 (CHO-CHRM2) CVCL_U004 (CHO-CHRM5) CVCL_U000 (CHO-CNR1) CVCL_5A37 (CHO-CUR2) CVCL_D583 (CHO-CUR3) CVCL_S542 (CHO-EE) CVCL_U005 (CHO-FFAR2) CVCL_T763 (CHO-FLAG-hBLT1) CVCL_1N80 (CHO-GAT) CVCL_U406 (CHO-glyA) CVCL_U407 (CHO-glyB) CVCL_U007 (CHO-GPR120) CVCL_H215 (CHO-GS) CVCL_T764 (CHO-HA-hBLT2) CVCL_LH55 (CHO-hAANAT) CVCL_1B31 (CHO-hD3) CVCL_X975 (CHO-hL1) CVCL_1F91 (CHO-hNCX1) CVCL_UW80 (CHO-HPX) CVCL_XD06 (CHO-HRH1) CVCL_1F92 (CHO-hTRPV1) CVCL_AS85 (CHO-ICAM-1Fc) CVCL_5I89 (CHO-K1 (+Galpha16) AequoScreen) CVCL_5I90 (CHO-K1 (+Gqi5) AequoScreen) CVCL_LF20 (CHO-K1 (GS Null) HD-BIOP3) CVCL_U864 (CHO-K1 (SC)) CVCL_KU49 (CHO-K1 ADRA1A Gq) CVCL_5I91 (CHO-K1 AequoScreen) CVCL_KU50 (CHO-K1 BDKRB1 Gq) CVCL_KU51 (CHO-K1 BRS3 Gq) CVCL_VG09 (CHO-K1 cat FFAR4) CVCL_XZ32 (CHO-K1 cyno ICOS) CVCL_XZ33 (CHO-K1 cyno MSLN) CVCL_XZ34 (CHO-K1 cyno TNFRSF1B) CVCL_XZ35 (CHO-K1 cyno TPBG) CVCL_KU52 (CHO-K1 CYSLTR2 Gq) CVCL_YD16 (CHO-K1 Dd-B6) CVCL_YD17 (CHO-K1 Dd-B7) CVCL_XZ36 (CHO-K1 dog CD47) CVCL_YD18 (CHO-K1 Ed-A1) CVCL_YD19 (CHO-K1 Ed-B8) CVCL_KU53 (CHO-K1 EDG3 Gq) CVCL_KU54 (CHO-K1 EDG4 Gq) CVCL_KU55 (CHO-K1 F2RL1 Gq) CVCL_KU56 (CHO-K1 FFAR1 Gq) CVCL_KU57 (CHO-K1 FFAR2 Gq) CVCL_KU58 (CHO-K1 GALR2 Gq) CVCL_KU59 (CHO-K1 GNRHR Gq) CVCL_KU60 (CHO-K1 GPR17 Gq) CVCL_LC01 (CHO-K1 h-GABA-b R1a/R2) CVCL_XZ37 (CHO-K1 human CD154(CD40L)) CVCL_XZ38 (CHO-K1 human CD16a-F158) CVCL_XZ39 (CHO-K1 human CD16a-V158) CVCL_UE26 (CHO-K1 human CD47) CVCL_XZ40 (CHO-K1 human CD70) CVCL_XZ41 (CHO-K1 human CLDN18.1) CVCL_XZ42 (CHO-K1 human CLDN18.2) CVCL_UE27 (CHO-K1 human INSR) CVCL_UE28 (CHO-K1 human MSLN) CVCL_XZ43 (CHO-K1 human NTRK1) CVCL_XZ44 (CHO-K1 human TNFRSF1B) CVCL_VU05 (CHO-K1 MMC-1) CVCL_VU06 (CHO-K1 MMC-2) CVCL_VU07 (CHO-K1 MMC-3) CVCL_VU08 (CHO-K1 MMC-4) CVCL_VU09 (CHO-K1 MMC-5) CVCL_XZ45 (CHO-K1 mouse ICOS) CVCL_XZ46 (CHO-K1 OS8) CVCL_XZ47 (CHO-K1 OS8-SIGLEC15) CVCL_KU61 (CHO-K1 PTGER1 Gq) CVCL_KU62 (CHO-K1 PTGFR Gq) CVCL_XZ48 (CHO-K1 rabbit CD47) CVCL_XZ49 (CHO-K1 rat CD47) CVCL_KU42 (CHO-K1 Tet-On) CVCL_ZE99 (CHO-K1 UA10) CVCL_AR65 (CHO-K1-AC-free) CVCL_Y502 (CHO-K1-BH4) CVCL_XI04 (CHO-K1-ESM) CVCL_1F96 (CHO-K1-Gln(-)) CVCL_9U94 (CHO-K1-SFM) CVCL_UW12 (CHO-K1-XIAP) CVCL_DE93 (CHO-K1.Cl-0204) CVCL_DE94 (CHO-K1.Cl-0205) CVCL_DE95 (CHO-K1.Cl-0206) CVCL_DE96 (CHO-K1.Cl-0235) CVCL_DE97 (CHO-K1.Cl-0236) CVCL_DE98 (CHO-K1.Cl-0237) CVCL_DE99 (CHO-K1.Cl-0238) CVCL_DF00 (CHO-K1.Cl-0239) CVCL_DF01 (CHO-K1.Cl-0270) CVCL_DF02 (CHO-K1.Cl6) CVCL_DF03 (CHO-K1.Cl7) CVCL_KA46 (CHO-K1/4-1BB) CVCL_H379 (CHO-K1/5-HT2A) CVCL_H380 (CHO-K1/5-HT2B) CVCL_H381 (CHO-K1/5-HT2C) CVCL_H387 (CHO-K1/ADRA1A) CVCL_H388 (CHO-K1/ADRA1B) CVCL_H389 (CHO-K1/ADRA1D) CVCL_H396 (CHO-K1/AM1) CVCL_KA47 (CHO-K1/B7-H3) CVCL_KA48 (CHO-K1/B7-H4) CVCL_H404 (CHO-K1/BB1) CVCL_H405 (CHO-K1/BB2) CVCL_H406 (CHO-K1/BB3) CVCL_KA49 (CHO-K1/BTLA) CVCL_H408 (CHO-K1/CASR) CVCL_H410 (CHO-K1/CB2) CVCL_H412 (CHO-K1/CCKB) CVCL_KA24 (CHO-K1/CD160) CVCL_KA22 (CHO-K1/CD16A 158F) CVCL_KA23 (CHO-K1/CD16B) CVCL_KA25 (CHO-K1/CD200 R1) CVCL_KA26 (CHO-K1/CD27) CVCL_KA28 (CHO-K1/CD32A 131Arg) CVCL_KA27 (CHO-K1/CD32A 131His) CVCL_KA29 (CHO-K1/CD32B 232Ile) CVCL_KA30 (CHO-K1/CD32B 232Thr) CVCL_KA31 (CHO-K1/CD32C 13Gln) CVCL_KA32 (CHO-K1/CD38) CVCL_KA33 (CHO-K1/CD40) CVCL_KA34 (CHO-K1/CD47) CVCL_KA35 (CHO-K1/CD80) CVCL_KA36 (CHO-K1/CD86) CVCL_H414 (CHO-K1/CRE-Luc) CVCL_KA77 (CHO-K1/CRE/Luc) CVCL_KA67 (CHO-K1/CT) CVCL_KA37 (CHO-K1/CTLA4) CVCL_KA50 (CHO-K1/cyno 4-1BB) CVCL_KA51 (CHO-K1/cyno CTLA4) CVCL_KA52 (CHO-K1/cyno FLT3) CVCL_KA53 (CHO-K1/cyno PD-1) CVCL_KA54 (CHO-K1/cyno PD-L1) CVCL_H419 (CHO-K1/CysLT2) CVCL_H420 (CHO-K1/D1) CVCL_H426 (CHO-K1/EDNRA) CVCL_H427 (CHO-K1/EDNRB) CVCL_KA38 (CHO-K1/FLT3) CVCL_H434 (CHO-K1/GAL2) CVCL_H446 (CHO-K1/Galpha15) CVCL_H435 (CHO-K1/GCGR/Galpha15) CVCL_H436 (CHO-K1/GHSR) CVCL_KA39 (CHO-K1/GITR) CVCL_H441 (CHO-K1/GPBAR1) CVCL_H447 (CHO-K1/Gqi5) CVCL_H512 (CHO-K1/hERG) CVCL_H452 (CHO-K1/KiSS1) CVCL_KA40 (CHO-K1/Lag3) CVCL_H454 (CHO-K1/M1) CVCL_H456 (CHO-K1/M3) CVCL_H458 (CHO-K1/M5) CVCL_H463 (CHO-K1/MCH2) CVCL_KA55 (CHO-K1/mouse 4-1BB) CVCL_KA19 (CHO-K1/mouse ADORA2A) CVCL_KA56 (CHO-K1/mouse CTLA4) CVCL_KA57 (CHO-K1/mouse FLT3) CVCL_KA58 (CHO-K1/mouse PD-1) CVCL_KA59 (CHO-K1/mouse PD-L1) CVCL_KA06 (CHO-K1/mouse TIGIT) CVCL_H465 (CHO-K1/MRGPRX2) CVCL_H470 (CHO-K1/NK1) CVCL_H471 (CHO-K1/NK2) CVCL_H472 (CHO-K1/NK3) CVCL_H473 (CHO-K1/NMU1) CVCL_H482 (CHO-K1/NTS1) CVCL_KA41 (CHO-K1/OX-40) CVCL_KA42 (CHO-K1/OX-40L) CVCL_H487 (CHO-K1/OX1) CVCL_H488 (CHO-K1/OX2) CVCL_H491 (CHO-K1/OXTR) CVCL_H494 (CHO-K1/PAR4) CVCL_KA44 (CHO-K1/PD-L1) CVCL_KA43 (CHO-K1/PD1) CVCL_H495 (CHO-K1/PRLHR) CVCL_H496 (CHO-K1/PTAFR) CVCL_8850 (CHO-K1/SF) CVCL_KA60 (CHO-K1/SIRP alpha) CVCL_KA61 (CHO-K1/SIRP gamma) CVCL_KA05 (CHO-K1/TIGIT) CVCL_KA45 (CHO-K1/Tim3) CVCL_H505 (CHO-K1/TRH1) CVCL_H507 (CHO-K1/V1A) CVCL_H508 (CHO-K1/V1B) CVCL_KA62 (CHO-K1/VISTA) CVCL_6F16 (CHO-K1v) CVCL_J422 (CHO-LY-A) CVCL_4701 (CHO-LY-B) CVCL_H628 (CHO-M19) CVCL_CW95 (CHO-mB7) CVCL_U366 (CHO-MCHR2) CVCL_S408 (CHO-MK42) CVCL_X976 (CHO-mL1) CVCL_DG55 (CHO-MOG) CVCL_YA13 (CHO-mPDPN) CVCL_U001 (CHO-NPY1R) CVCL_U008 (CHO-OPRL1) CVCL_S541 (CHO-PI) CVCL_VA36 (CHO-R5) CVCL_4669 (CHO-RD) CVCL_S543 (CHO-SEC) CVCL_EP77 (CHO-SNS22) CVCL_T760 (CHO-SPB-1) CVCL_U009 (CHO-SSTR1) CVCL_U420 (CHO-TRVb) CVCL_5A23 (CHO-UKB25) CVCL_S544 (CHO-WT) CVCL_5A38 (CHO-xrs-1) CVCL_5A39 (CHO-xrs-4) CVCL_4601 (CHO-xrs-5) CVCL_4340 (CHO-xrs-6) CVCL_5A40 (CHO-xrs-7) CVCL_T032 (CHO.1F8) CVCL_A8V4 (CHO/CD20) CVCL_KS38 (CHO/CREB-luc) CVCL_IY41 (CHO/Galpha16) CVCL_IY42 (CHO/Gqi5 G418-resistant) CVCL_IY43 (CHO/Gqi5 hygromycin-resistant) CVCL_IY44 (CHO/Gqo5) CVCL_IY45 (CHO/Gqs5 G418-resistant) CVCL_IY46 (CHO/Gqs5 hygromycin-resistant) CVCL_IY47 (CHO/Gqz5 G418-resistant) CVCL_IY48 (CHO/Gqz5 hygromycin-resistant) CVCL_HC54 (CHO/Kcnk3) CVCL_HC55 (CHO/Kcnk3/Kcnk9) CVCL_HC56 (CHO/Kcnk9) CVCL_F973 (CHO/OAR2-3) CVCL_F974 (CHO/OAR6-6) CVCL_RU92 (CHO10PV) CVCL_IM59 (CHO12RO) CVCL_RU93 (CHO181PV) CVCL_RU94 (CHO191PV) CVCL_RU95 (CHO192PV) CVCL_RU96 (CHO201PV) CVCL_RU97 (CHO202PV) CVCL_RU98 (CHO203PV) CVCL_RU99 (CHO204PV) CVCL_RV00 (CHO205PV) CVCL_RV01 (CHO211PV) CVCL_RV02 (CHO23PV) CVCL_RV03 (CHO2PV) CVCL_RV04 (CHO302PV) CVCL_RV05 (CHO30PV) CVCL_IM60 (CHO33RO) CVCL_RV06 (CHO3PV) CVCL_RV07 (CHO40PV) CVCL_RV08 (CHO421PV) CVCL_RV09 (CHO423PV) CVCL_IM61 (CHO43RO) CVCL_RV10 (CHO4PV) CVCL_RV11 (CHO50PV) CVCL_RV12 (CHO51PV) CVCL_RV13 (CHO5PV) CVCL_RV14 (CHO60PV) CVCL_RV15 (CHO7PV) CVCL_RV16 (CHO9PV) CVCL_VN06 (CHOExpress) CVCL_DR95 (CHOK1SV) CVCL_RJ71 (CHOP-TU) CVCL_HA81 (CHOR 3-4) CVCL_UG11 (CHOR16) CVCL_HB34 (CHOTKa) CVCL_RN03 (CHOZN GS-/-) CVCL_DD09 (CsR-1000) CVCL_U417 (DTE 1-6-4) CVCL_U418 (DTF 1-5-1) CVCL_U419 (DTG 1-5-4) CVCL_VU25 (E46.4) CVCL_VU26 (E77.4) CVCL_U424 (Flp-In-CHO) CVCL_KR96 (GeneBLAzer CMV-bla CHO-K1) CVCL_1S10 (GM10926) CVCL_1S24 (GM11418) CVCL_DD03 (HA-CHO) CVCL_VL22 (hD2L-CHO) CVCL_VL23 (hD3-CHO) CVCL_6G75 (IA1-7) CVCL_VL74 (JPO2) CVCL_VL73 (JPO9) CVCL_W354 (JW152) CVCL_1V03 (LdlD) CVCL_JY00 (LdlF) CVCL_A9P5 (LIGHT-CHO) CVCL_YJ77 (LINTERNA CHO-K1) CVCL_3842 (M1WT2) CVCL_3843 (M1WT3) CVCL_3844 (M1WT5) CVCL_4579 (M3WT4) CVCL_4580 (M3WT5) CVCL_4581 (M3WT8) CVCL_IP24 (MI5-4) CVCL_IP25 (MI8-5) CVCL_HC53 (mRG1) CVCL_0442 (MT58) CVCL_JA54 (NCI-CHOdeltafurin) CVCL_A9P1 (NF-KappaB reporter (Luc)-CHO-K1) CVCL_U863 (NLS-6-5) CVCL_KW22 (PathHunter CHO-K1 ADCYAP1R1 beta-arrestin) CVCL_KW23 (PathHunter CHO-K1 ADORA1 beta-arrestin) CVCL_KW24 (PathHunter CHO-K1 ADORA3 beta-arrestin) CVCL_KW25 (PathHunter CHO-K1 ADRA1B beta-arrestin) CVCL_KW26 (PathHunter CHO-K1 ADRA2A beta-arrestin) CVCL_KW27 (PathHunter CHO-K1 ADRA2B beta-arrestin) CVCL_KW28 (PathHunter CHO-K1 ADRA2C beta-arrestin) CVCL_KW29 (PathHunter CHO-K1 ADRB1 beta-arrestin) CVCL_KW30 (PathHunter CHO-K1 ADRB2 beta-arrestin) CVCL_KW31 (PathHunter CHO-K1 AGTR1 beta-arrestin) CVCL_KW32 (PathHunter CHO-K1 AGTRL1 beta-arrestin) CVCL_KW33 (PathHunter CHO-K1 AGTRL1 beta-arrestin-1) CVCL_KW34 (PathHunter CHO-K1 AR Protein Interaction) CVCL_KW35 (PathHunter CHO-K1 AVPR1B beta-arrestin) CVCL_KW36 (PathHunter CHO-K1 AVPR2 beta-arrestin) CVCL_KW37 (PathHunter CHO-K1 BAI1 beta-arrestin) CVCL_KW38 (PathHunter CHO-K1 BAI2 beta-arrestin) CVCL_KW39 (PathHunter CHO-K1 BAI3 beta-arrestin) CVCL_KW40 (PathHunter CHO-K1 BDKRB1 beta-arrestin) CVCL_KW41 (PathHunter CHO-K1 BDKRB2 beta-arrestin) CVCL_KW42 (PathHunter CHO-K1 beta-arrestin1-EA Parental) CVCL_KW43 (PathHunter CHO-K1 beta-arrestin2-EA Parental) CVCL_KW44 (PathHunter CHO-K1 BRS3 beta-arrestin) CVCL_KW45 (PathHunter CHO-K1 C5AR1 beta-arrestin) CVCL_KW46 (PathHunter CHO-K1 C5L2 beta-arrestin) CVCL_KW47 (PathHunter CHO-K1 CALCR beta-arrestin) CVCL_KW48 (PathHunter CHO-K1 CALCR-RAMP1 beta-arrestin) CVCL_KW51 (PathHunter CHO-K1 CALCR-RAMP2 beta-arrestin) CVCL_KW52 (PathHunter CHO-K1 CALCR-RAMP3 beta-arrestin) CVCL_KW49 (PathHunter CHO-K1 CALCRL-RAMP2 beta-arrestin) CVCL_KW50 (PathHunter CHO-K1 CALCRL-RAMP3 beta-arrestin) CVCL_KW53 (PathHunter CHO-K1 CCKAR beta-arrestin) CVCL_KW54 (PathHunter CHO-K1 CCKBR beta-arrestin) CVCL_KW55 (PathHunter CHO-K1 CCR1 beta-arrestin) CVCL_KW56 (PathHunter CHO-K1 CCR2 beta-arrestin) CVCL_KW57 (PathHunter CHO-K1 CCR3 beta-arrestin) CVCL_KW58 (PathHunter CHO-K1 CCR4 beta-arrestin) CVCL_KW59 (PathHunter CHO-K1 CCR5 beta-arrestin) CVCL_KW60 (PathHunter CHO-K1 CCR6 beta-arrestin) CVCL_KW61 (PathHunter CHO-K1 CCR7 beta-arrestin) CVCL_KW62 (PathHunter CHO-K1 CCR8 beta-arrestin) CVCL_KW63 (PathHunter CHO-K1 CCR9 beta-arrestin) CVCL_KW64 (PathHunter CHO-K1 CCRL1 beta-arrestin) CVCL_KW65 (PathHunter CHO-K1 CCRL2 beta-arrestin) CVCL_KW66 (PathHunter CHO-K1 cEDG5 beta-arrestin) CVCL_KW67 (PathHunter CHO-K1 CHRM1 beta-arrestin) CVCL_KW68 (PathHunter CHO-K1 CHRM2 beta-arrestin) CVCL_KW69 (PathHunter CHO-K1 CHRM4 beta-arrestin) CVCL_KW70 (PathHunter CHO-K1 CHRM5 beta-arrestin) CVCL_KW71 (PathHunter CHO-K1 CMKLR1 beta-arrestin) CVCL_KW72 (PathHunter CHO-K1 CNR1 beta-arrestin) CVCL_KW73 (PathHunter CHO-K1 CNR2 beta-arrestin) CVCL_KW74 (PathHunter CHO-K1 CRHR1 beta-arrestin) CVCL_KW75 (PathHunter CHO-K1 CRHR2 beta-arrestin) CVCL_KW76 (PathHunter CHO-K1 CRTH2 beta-arrestin) CVCL_KW77 (PathHunter CHO-K1 CX3CR1 beta-arrestin) CVCL_KW78 (PathHunter CHO-K1 CXCR2 beta-arrestin) CVCL_KW79 (PathHunter CHO-K1 CXCR3 beta-arrestin) CVCL_KW80 (PathHunter CHO-K1 CXCR5 beta-arrestin) CVCL_KW81 (PathHunter CHO-K1 CXCR6 beta-arrestin) CVCL_KW82 (PathHunter CHO-K1 CXCR7 beta-arrestin) CVCL_KW83 (PathHunter CHO-K1 cyno GPR120 beta-arrestin) CVCL_KW84 (PathHunter CHO-K1 DARC beta-arrestin) CVCL_KW85 (PathHunter CHO-K1 DRD1 beta-arrestin) CVCL_KW86 (PathHunter CHO-K1 DRD2L beta-arrestin) CVCL_KW87 (PathHunter CHO-K1 DRD2S beta-arrestin) CVCL_KW88 (PathHunter CHO-K1 DRD3 beta-arrestin) CVCL_KW89 (PathHunter CHO-K1 DRD4 beta-arrestin) CVCL_KW90 (PathHunter CHO-K1 DRD5 beta-arrestin) CVCL_KW91 (PathHunter CHO-K1 EBI2 beta-arrestin) CVCL_KW92 (PathHunter CHO-K1 EDG1 beta-arrestin) CVCL_KW93 (PathHunter CHO-K1 EDG2 beta-arrestin) CVCL_KW94 (PathHunter CHO-K1 EDG3 beta-arrestin) CVCL_KW95 (PathHunter CHO-K1 EDG4 beta-arrestin) CVCL_KW96 (PathHunter CHO-K1 EDG5 beta-arrestin) CVCL_KW97 (PathHunter CHO-K1 EDG6 beta-arrestin) CVCL_KW98 (PathHunter CHO-K1 EDG7 beta-arrestin) CVCL_KW99 (PathHunter CHO-K1 EDNRA beta-arrestin) CVCL_KX00 (PathHunter CHO-K1 EDNRB beta-arrestin) CVCL_KX01 (PathHunter CHO-K1 ERalpha Protein Interaction) CVCL_KX02 (PathHunter CHO-K1 F2R beta-arrestin) CVCL_KX03 (PathHunter CHO-K1 F2RL3 beta-arrestin) CVCL_KX04 (PathHunter CHO-K1 FFAR2 beta-arrestin) CVCL_KX05 (PathHunter CHO-K1 FPR1 beta-arrestin) CVCL_KX06 (PathHunter CHO-K1 FPRL1 beta-arrestin) CVCL_KX07 (PathHunter CHO-K1 FSHR beta-arrestin) CVCL_KX08 (PathHunter CHO-K1 FXR Protein Interaction) CVCL_KX09 (PathHunter CHO-K1 GALR1 beta-arrestin) CVCL_KX10 (PathHunter CHO-K1 GALR2 beta-arrestin) CVCL_KX11 (PathHunter CHO-K1 GCGR beta-arrestin) CVCL_KX12 (PathHunter CHO-K1 GCGR beta-arrestin-1) CVCL_KX13 (PathHunter CHO-K1 GHSR1b beta-arrestin) CVCL_KX14 (PathHunter CHO-K1 GIPR beta-arrestin) CVCL_KX15 (PathHunter CHO-K1 GLP1R beta-arrestin) CVCL_KX16 (PathHunter CHO-K1 GLP1R beta-arrestin-1) CVCL_KX17 (PathHunter CHO-K1 GLP2R beta-arrestin) CVCL_KX18 (PathHunter CHO-K1 GPR1 beta-arrestin) CVCL_KX19 (PathHunter CHO-K1 GPR101 beta-arrestin) CVCL_KX20 (PathHunter CHO-K1 GPR103 beta-arrestin) CVCL_KX21 (PathHunter CHO-K1 GPR107 beta-arrestin) CVCL_KX22 (PathHunter CHO-K1 GPR109A beta-arrestin) CVCL_KX23 (PathHunter CHO-K1 GPR109B beta-arrestin) CVCL_KX24 (PathHunter CHO-K1 GPR12 beta-arrestin) CVCL_KX25 (PathHunter CHO-K1 GPR120L beta-arrestin) CVCL_KX26 (PathHunter CHO-K1 GPR120S beta-arrestin) CVCL_KX27 (PathHunter CHO-K1 GPR120S beta-arrestin-1) CVCL_KX28 (PathHunter CHO-K1 GPR123 beta-arrestin) CVCL_KX29 (PathHunter CHO-K1 GPR132 beta-arrestin) CVCL_KX30 (PathHunter CHO-K1 GPR135 beta-arrestin) CVCL_KX31 (PathHunter CHO-K1 GPR137 beta-arrestin) CVCL_KX32 (PathHunter CHO-K1 GPR139 beta-arrestin) CVCL_KX33 (PathHunter CHO-K1 GPR141 beta-arrestin) CVCL_KX34 (PathHunter CHO-K1 GPR142 beta-arrestin) CVCL_KX35 (PathHunter CHO-K1 GPR143 beta-arrestin) CVCL_KX36 (PathHunter CHO-K1 GPR146 beta-arrestin) CVCL_KX37 (PathHunter CHO-K1 GPR148 beta-arrestin) CVCL_KX38 (PathHunter CHO-K1 GPR149 beta-arrestin) CVCL_KX39 (PathHunter CHO-K1 GPR15 beta-arrestin) CVCL_KX40 (PathHunter CHO-K1 GPR150 beta-arrestin) CVCL_KX41 (PathHunter CHO-K1 GPR151 beta-arrestin) CVCL_KX42 (PathHunter CHO-K1 GPR152 beta-arrestin) CVCL_KX43 (PathHunter CHO-K1 GPR157 beta-arrestin) CVCL_KX44 (PathHunter CHO-K1 GPR161 beta-arrestin) CVCL_KX45 (PathHunter CHO-K1 GPR162 beta-arrestin) CVCL_KX46 (PathHunter CHO-K1 GPR171 beta-arrestin) CVCL_KX47 (PathHunter CHO-K1 GPR173 beta-arrestin) CVCL_KX48 (PathHunter CHO-K1 GPR176 beta-arrestin) CVCL_KX49 (PathHunter CHO-K1 GPR18 beta-arrestin) CVCL_KX50 (PathHunter CHO-K1 GPR182 beta-arrestin) CVCL_KX51 (PathHunter CHO-K1 GPR23 beta-arrestin) CVCL_KX52 (PathHunter CHO-K1 GPR25 beta-arrestin) CVCL_KX53 (PathHunter CHO-K1 GPR26 beta-arrestin) CVCL_KX54 (PathHunter CHO-K1 GPR27 beta-arrestin) CVCL_KX55 (PathHunter CHO-K1 GPR3 beta-arrestin) CVCL_KX56 (PathHunter CHO-K1 GPR30 beta-arrestin) CVCL_KX57 (PathHunter CHO-K1 GPR31 beta-arrestin) CVCL_KX58 (PathHunter CHO-K1 GPR32 beta-arrestin) CVCL_KX59 (PathHunter CHO-K1 GPR35 beta-arrestin) CVCL_KX60 (PathHunter CHO-K1 GPR37 beta-arrestin) CVCL_KX61 (PathHunter CHO-K1 GPR37L1 beta-arrestin) CVCL_KX62 (PathHunter CHO-K1 GPR39 beta-arrestin) CVCL_KX63 (PathHunter CHO-K1 GPR4 beta-arrestin) CVCL_KX64 (PathHunter CHO-K1 GPR45 beta-arrestin) CVCL_KX65 (PathHunter CHO-K1 GPR50 beta-arrestin) CVCL_KX66 (PathHunter CHO-K1 GPR52 beta-arrestin) CVCL_KX67 (PathHunter CHO-K1 GPR55 beta-arrestin) CVCL_KX68 (PathHunter CHO-K1 GPR6 beta-arrestin) CVCL_KX69 (PathHunter CHO-K1 GPR61 beta-arrestin) CVCL_KX70 (PathHunter CHO-K1 GPR65 beta-arrestin) CVCL_KX71 (PathHunter CHO-K1 GPR75 beta-arrestin) CVCL_KX72 (PathHunter CHO-K1 GPR78 beta-arrestin) CVCL_KX73 (PathHunter CHO-K1 GPR79 beta-arrestin) CVCL_KX74 (PathHunter CHO-K1 GPR83 beta-arrestin) CVCL_KX75 (PathHunter CHO-K1 GPR84 beta-arrestin) CVCL_KX76 (PathHunter CHO-K1 GPR85 beta-arrestin) CVCL_KX77 (PathHunter CHO-K1 GPR88 beta-arrestin) CVCL_KX78 (PathHunter CHO-K1 GPR92 beta-arrestin) CVCL_KX79 (PathHunter CHO-K1 GPR97 beta-arrestin) CVCL_KX80 (PathHunter CHO-K1 GR Protein Interaction) CVCL_KX81 (PathHunter CHO-K1 HCRTR1 beta-arrestin) CVCL_KX82 (PathHunter CHO-K1 HCRTR2 beta-arrestin) CVCL_KX83 (PathHunter CHO-K1 HRH1 beta-arrestin) CVCL_KX84 (PathHunter CHO-K1 HRH2 beta-arrestin) CVCL_KX85 (PathHunter CHO-K1 HRH3 beta-arrestin) CVCL_KX86 (PathHunter CHO-K1 HTR1A beta-arrestin) CVCL_KX87 (PathHunter CHO-K1 LGR4 beta-arrestin) CVCL_KX88 (PathHunter CHO-K1 LGR5 beta-arrestin) CVCL_KX89 (PathHunter CHO-K1 LGR6 beta-arrestin) CVCL_KX90 (PathHunter CHO-K1 LHCGR beta-arrestin) CVCL_KX91 (PathHunter CHO-K1 LTB4R beta-arrestin) CVCL_KX92 (PathHunter CHO-K1 LXRalpha Protein Interaction) CVCL_KX93 (PathHunter CHO-K1 LXRbeta Protein Interaction) CVCL_KX94 (PathHunter CHO-K1 mADCYAP1R1 beta-arrestin) CVCL_KX95 (PathHunter CHO-K1 mADORA2B beta-arrestin) CVCL_KX96 (PathHunter CHO-K1 mADORA3 beta-arrestin) CVCL_KX97 (PathHunter CHO-K1 mAGTRL1 beta-arrestin) CVCL_KX98 (PathHunter CHO-K1 mC5AR1 beta-arrestin) CVCL_KX99 (PathHunter CHO-K1 MC5R beta-arrestin) CVCL_KY00 (PathHunter CHO-K1 mCCR3 beta-arrestin) CVCL_KY01 (PathHunter CHO-K1 mCCR4 beta-arrestin) CVCL_KY02 (PathHunter CHO-K1 mCCR5 beta-arrestin) CVCL_KY03 (PathHunter CHO-K1 mCCR6 beta-arrestin) CVCL_KY04 (PathHunter CHO-K1 mCCR7 beta-arrestin) CVCL_KY05 (PathHunter CHO-K1 mCCR8 beta-arrestin) CVCL_KY06 (PathHunter CHO-K1 mCCR9 beta-arrestin) CVCL_KY07 (PathHunter CHO-K1 mCMKLR1 beta-arrestin) CVCL_KY08 (PathHunter CHO-K1 mCNR1 beta-arrestin) CVCL_KY09 (PathHunter CHO-K1 mCNR2 beta-arrestin) CVCL_KY10 (PathHunter CHO-K1 mCRHR1 beta-arrestin) CVCL_KY11 (PathHunter CHO-K1 mCRTH2 beta-arrestin) CVCL_KY12 (PathHunter CHO-K1 mCXCR2 beta-arrestin) CVCL_KY13 (PathHunter CHO-K1 mCXCR3 beta-arrestin) CVCL_KY14 (PathHunter CHO-K1 mCXCR5 beta-arrestin) CVCL_KY15 (PathHunter CHO-K1 mCXCR6 beta-arrestin) CVCL_KY16 (PathHunter CHO-K1 mDRD5 beta-arrestin) CVCL_KY17 (PathHunter CHO-K1 mEBI2 beta-arrestin) CVCL_KY18 (PathHunter CHO-K1 mEDG1 beta-arrestin) CVCL_KY19 (PathHunter CHO-K1 mEDG3 beta-arrestin) CVCL_KY20 (PathHunter CHO-K1 mEDG5 beta-arrestin) CVCL_KY21 (PathHunter CHO-K1 mEDNRA beta-arrestin) CVCL_KY22 (PathHunter CHO-K1 mEDNRB beta-arrestin) CVCL_KY23 (PathHunter CHO-K1 mFPR1 beta-arrestin) CVCL_KY24 (PathHunter CHO-K1 mFPR2 beta-arrestin) CVCL_KY25 (PathHunter CHO-K1 mGALR2 beta-arrestin) CVCL_KY26 (PathHunter CHO-K1 mGCGR beta-arrestin) CVCL_KY27 (PathHunter CHO-K1 mGCGR beta-arrestin-1) CVCL_KY28 (PathHunter CHO-K1 mGHSR1a beta-arrestin) CVCL_KY29 (PathHunter CHO-K1 mGLP1R beta-arrestin) CVCL_KY30 (PathHunter CHO-K1 mGLP1R beta-arrestin-1) CVCL_KY31 (PathHunter CHO-K1 mGPR1 beta-arrestin) CVCL_KY32 (PathHunter CHO-K1 mGPR84 beta-arrestin) CVCL_KY33 (PathHunter CHO-K1 mHTR2A beta-arrestin) CVCL_KY34 (PathHunter CHO-K1 MLNR beta-arrestin) CVCL_KY35 (PathHunter CHO-K1 mLTB4R1 beta-arrestin) CVCL_KY36 (PathHunter CHO-K1 mMCHR1 beta-arrestin) CVCL_KY37 (PathHunter CHO-K1 mNPY2R beta-arrestin) CVCL_KY38 (PathHunter CHO-K1 mOPRD1 beta-arrestin) CVCL_KY39 (PathHunter CHO-K1 mOPRK1 beta-arrestin) CVCL_KY40 (PathHunter CHO-K1 mOXTR beta-arrestin) CVCL_KY41 (PathHunter CHO-K1 mP2RY12 beta-arrestin) CVCL_KY42 (PathHunter CHO-K1 mPPYR1 beta-arrestin) CVCL_KY43 (PathHunter CHO-K1 mPTAFR beta-arrestin) CVCL_KY44 (PathHunter CHO-K1 MR Protein Interaction) CVCL_KY45 (PathHunter CHO-K1 MRGPRD beta-arrestin) CVCL_KY46 (PathHunter CHO-K1 MRGPRE beta-arrestin) CVCL_KY47 (PathHunter CHO-K1 MRGPRF beta-arrestin) CVCL_KY48 (PathHunter CHO-K1 MRGPRX1 beta-arrestin) CVCL_KY49 (PathHunter CHO-K1 MRGPRX2 beta-arrestin) CVCL_KY50 (PathHunter CHO-K1 MRGPRX4 beta-arrestin) CVCL_KY51 (PathHunter CHO-K1 mRXFP3 beta-arrestin) CVCL_KY52 (PathHunter CHO-K1 mRXFP4 beta-arrestin) CVCL_KY53 (PathHunter CHO-K1 mSSTR2 beta-arrestin) CVCL_KY54 (PathHunter CHO-K1 mSSTR5 beta-arrestin) CVCL_KY55 (PathHunter CHO-K1 MTNR1A beta-arrestin) CVCL_KY56 (PathHunter CHO-K1 MTNR1B beta-arrestin) CVCL_KY57 (PathHunter CHO-K1 mUTR2 beta-arrestin) CVCL_KY58 (PathHunter CHO-K1 mVIPR1 beta-arrestin) CVCL_KY59 (PathHunter CHO-K1 NMBR beta-arrestin) CVCL_KY60 (PathHunter CHO-K1 NPBWR1 beta-arrestin) CVCL_KY61 (PathHunter CHO-K1 NPBWR2 beta-arrestin) CVCL_KY62 (PathHunter CHO-K1 NPFFR1 beta-arrestin) CVCL_KY63 (PathHunter CHO-K1 NPR1 Functional Assay) CVCL_KY64 (PathHunter CHO-K1 NPY1R beta-arrestin) CVCL_KY65 (PathHunter CHO-K1 NPY2R beta-arrestin) CVCL_KY66 (PathHunter CHO-K1 NTSR1 beta-arrestin) CVCL_KY67 (PathHunter CHO-K1 OPN5 beta-arrestin) CVCL_KY68 (PathHunter CHO-K1 OPRD1 beta-arrestin) CVCL_KY69 (PathHunter CHO-K1 OPRL1 beta-arrestin) CVCL_KY70 (PathHunter CHO-K1 OPRM1 beta-arrestin) CVCL_KY71 (PathHunter CHO-K1 OXER1 beta-arrestin) CVCL_KY72 (PathHunter CHO-K1 OXGR1 beta-arrestin) CVCL_KY73 (PathHunter CHO-K1 OXTR beta-arrestin) CVCL_KY74 (PathHunter CHO-K1 P2RY11 beta-arrestin) CVCL_KY75 (PathHunter CHO-K1 P2RY12 beta-arrestin) CVCL_KY76 (PathHunter CHO-K1 P2RY4 beta-arrestin) CVCL_KY77 (PathHunter CHO-K1 P2RY6 beta-arrestin) CVCL_KY78 (PathHunter CHO-K1 P2RY8 beta-arrestin) CVCL_KY79 (PathHunter CHO-K1 PPARalpha Protein Interaction) CVCL_KY80 (PathHunter CHO-K1 PPARdelta Protein Interaction) CVCL_KY81 (PathHunter CHO-K1 PPARgamma Protein Interaction) CVCL_KY82 (PathHunter CHO-K1 PPYR1 beta-arrestin) CVCL_KY83 (PathHunter CHO-K1 PRLHR beta-arrestin) CVCL_KY84 (PathHunter CHO-K1 PROKR1 beta-arrestin) CVCL_KY85 (PathHunter CHO-K1 PROKR2 beta-arrestin) CVCL_KY86 (PathHunter CHO-K1 PTAFR beta-arrestin) CVCL_KY87 (PathHunter CHO-K1 PTGER2 beta-arrestin) CVCL_KY88 (PathHunter CHO-K1 PTGER3 beta-arrestin) CVCL_KY89 (PathHunter CHO-K1 PTGIR beta-arrestin) CVCL_KY90 (PathHunter CHO-K1 PTHR1 beta-arrestin) CVCL_KY91 (PathHunter CHO-K1 PTHR2 beta-arrestin) CVCL_KY92 (PathHunter CHO-K1 RARalpha Protein Interaction) CVCL_KY93 (PathHunter CHO-K1 RARbeta Protein Interaction) CVCL_KY94 (PathHunter CHO-K1 rCHRM4 beta-arrestin) CVCL_KY95 (PathHunter CHO-K1 rCRTH2 beta-arrestin) CVCL_KY96 (PathHunter CHO-K1 rDRD1 beta-arrestin) CVCL_KY97 (PathHunter CHO-K1 rDRD2L beta-arrestin) CVCL_KY98 (PathHunter CHO-K1 rDRD2S beta-arrestin) CVCL_KY99 (PathHunter CHO-K1 rEDG5 beta-arrestin) CVCL_KZ00 (PathHunter CHO-K1 rGPR120 beta-arrestin) CVCL_KZ01 (PathHunter CHO-K1 rGPR35 beta-arrestin) CVCL_KZ02 (PathHunter CHO-K1 rOPRM1 beta-arrestin) CVCL_KZ03 (PathHunter CHO-K1 rPROKR1 beta-arrestin) CVCL_KZ04 (PathHunter CHO-K1 rPROKR2 beta-arrestin) CVCL_KZ05 (PathHunter CHO-K1 rVIPR1 beta-arrestin) CVCL_KZ06 (PathHunter CHO-K1 RXFP3 beta-arrestin) CVCL_KZ07 (PathHunter CHO-K1 RXFP4 beta-arrestin) CVCL_KZ08 (PathHunter CHO-K1 RXRgamma Protein Interaction) CVCL_KZ09 (PathHunter CHO-K1 SCTR beta-arrestin) CVCL_KZ10 (PathHunter CHO-K1 sEDG5 beta-arrestin) CVCL_KZ11 (PathHunter CHO-K1 SSTR2 Activated GPCR Internalization) CVCL_KZ12 (PathHunter CHO-K1 SSTR2 beta-arrestin) CVCL_KZ13 (PathHunter CHO-K1 SSTR3 beta-arrestin) CVCL_KZ14 (PathHunter CHO-K1 SSTR4 beta-arrestin) CVCL_KZ15 (PathHunter CHO-K1 SSTR5 beta-arrestin) CVCL_KZ16 (PathHunter CHO-K1 TAAR5 beta-arrestin) CVCL_KZ17 (PathHunter CHO-K1 TACR1 beta-arrestin) CVCL_KZ18 (PathHunter CHO-K1 TACR2 beta-arrestin) CVCL_KZ19 (PathHunter CHO-K1 TACR3 beta-arrestin) CVCL_KZ20 (PathHunter CHO-K1 THRalpha Protein Interaction) CVCL_KZ21 (PathHunter CHO-K1 THRbeta Protein Interaction) CVCL_KZ22 (PathHunter CHO-K1 TRHR beta-arrestin) CVCL_KZ23 (PathHunter CHO-K1 UTR2 beta-arrestin) CVCL_KZ24 (PathHunter CHO-K1 VIPR1 beta-arrestin) CVCL_KZ25 (PathHunter CHO-K1 VIPR2 beta-arrestin) CVCL_KZ26 (PathHunter CHO-K1 XCR1 beta-arrestin) CVCL_4589 (pgsA-745) CVCL_4590 (pgsB-618) CVCL_4591 (pgsB-650) CVCL_4592 (pgsC-605) CVCL_4593 (pgsD-677) CVCL_4594 (pgsE-606) CVCL_VQ78 (pgsF-17) CVCL_VQ79 (pgsG-224) CVCL_RQ82 (PrecisION hHCN4-CHO) CVCL_LC64 (PrecisION hKCNQ1/hminK-CHO) CVCL_LC65 (PrecisION hKv1.5-CHO) CVCL_LC66 (PrecisION hNav1.2-CHO) CVCL_RQ79 (PrecisION hNav1.3-CHO) CVCL_XJ64 (PT1-1) CVCL_XJ66 (PT1-30) CVCL_XJ67 (PT1-55) CVCL_XJ65 (PT1-7) CVCL_U563 (RPE.40) CVCL_4294 (RR-CHOKI) CVCL_4V70 (SK24) CVCL_4708 (SK32) CVCL_IR03 (Super-CHO C1) CVCL_IR04 (Super-CHO C2) CVCL_IR06 (Super-CHO ISS9) CVCL_R728 (SURE CHO-M) CVCL_DD10 (SwR-100) CVCL_D586 (T-REx-CHO) CVCL_U010 (T02J-10/10) CVCL_U011 (T02J-7/10) CVCL_U012 (T02J-9/10) CVCL_U013 (T26J-1/09) CVCL_U014 (T35J-5/09) CVCL_LH73 (tsTM13) CVCL_J507 (tsTM18) CVCL_LH72 (tsTM3) CVCL_J617 (tsTM4) CVCL_T762 (UPS-1) CVCL_1N54 (Urd-A) CVCL_1N55 (Urd-B) CVCL_1N56 (Urd-C) CVCL_4332 (UT-1) CVCL_DC04 (UT-2) CVCL_RQ08 (ValiScreen human CCR1) CVCL_RQ09 (ValiScreen human CCR2b) CVCL_RQ16 (ValiScreen human CHRM1) CVCL_RQ17 (ValiScreen human CHRM2) CVCL_RQ18 (ValiScreen human CHRM3) CVCL_RQ19 (ValiScreen human CHRM4) CVCL_RQ20 (ValiScreen human CHRM5) CVCL_LC58 (ValiScreen human CRTH2) CVCL_RP99 (ValiScreen human CX3CR1) CVCL_RQ07 (ValiScreen human CXCR3) CVCL_YJ66 (VAMPIRO CHO-K1) CVCL_HB35 (Z24) CVCL_HB89 (Z65) CVCL_HB32 (ZP92) CVCL_8025 (ZR-78) CVCL_8027 (ZR-82) CVCL_8028 (ZR-87) | škrečok čínsky | Cricetulus griseus | zvieracia | etická | CHO K1; CHOK1; CHO cell clone K1; GM15452 | Bunková línia využívaná pri produkcii vakcín | / | / | Spontánne imortalizované bunkové línie | ovariálne | ženské | dospelé | / | Doubling time: ~24 hours (DSMZ). Omics: Deep RNAseq analysis. Omics: Genome sequenced. Omics: Metabolome analysis. Omics: miRNA expression profiling. Omics: Transcriptome analysis. | PubMed=10320750; DOI=10.1016/S0027-5107(99)00077-9 Hu T., Miller C.M., Ridder G.M., Aardema M.J. Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing. Mutat. Res. 426:51-62(1999) PubMed=21804562; DOI=10.1038/nbt.1932 Xu X., Nagarajan H., Lewis N.E., Pan S.-K., Cai Z.-M., Liu X., Chen W.-B., Xie M., Wang W.-L., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W., Fan H.C., Wang J.-B., Gui Y.-T., Lee K.H., Betenbaugh M.J., Quake S.R., Famili I., Palsson B.O., Wang J. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat. Biotechnol. 29:735-741(2011) PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014 Becker J., Hackl M., Rupp O., Jakobi T., Schneider J., Szczepanowski R., Bekel T., Borth N., Goesmann A., Grillari J., Kaltschmidt C., Noll T., Puhler A., Tauch A., Brinkrolf K. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J. Biotechnol. 156:227-235(2011) DOI=10.3390/pr1030296 Wurm F.M. CHO quasispecies -- implications for manufacturing processes. Processes 1:296-311(2013) PubMed=23873082; DOI=10.1038/nbt.2624 Lewis N.E., Liu X., Li Y.-X., Nagarajan H., Yerganian G., O'Brien E., Bordbar A., Roth A.M., Rosenbloom J., Bian C., Xie M., Chen W.-B., Li N., Baycin-Hizal D., Latif H., Forster J., Betenbaugh M.J., Famili I., Xu X., Wang J., Palsson B.O. Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nat. Biotechnol. 31:759-765(2013) PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022 Klanert G., Jadhav V., Shanmukam V., Diendorfer A., Karbiener M., Scheideler M., Bort J.H., Grillari J., Hackl M., Borth N. A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines. J. Biotechnol. 235:150-161(2016) DOI=10.3390/pr5020020 Wurm F.M., Wurm M.J. Cloning of CHO cells, productivity and genetic stability -- a discussion. Processes 5:20.1-20.13(2017) PubMed=28544881; DOI=10.1016/j.cels.2017.04.009 Yusufi F.N.K., Lakshmanan M., Ho Y.-S., Loo B.L.-W., Ariyaratne P., Yang Y., Ng S.-K., Tan T.R.-M., Yeo H.C., Lim H.L., Ng S.-W., Hiu A.-P., Chow C.-P., Wan C., Chen S., Teo G., Song G., Chin J.X., Ruan X., Sung K.W.-K., Hu W.-S., Yap M.G.-S., Bardor M., Nagarajan N., Lee D.-Y. Mammalian systems biotechnology reveals global cellular adaptations in a recombinant CHO cell line. Cell Syst. 4:530-542.e6(2017) PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002 Szeliova D., Ruckerbauer D.E., Galleguillos S.N., Petersen L.B., Natter K., Hanscho M., Troyer C., Causon T., Schoeny H., Christensen H.B., Lee D.Y., Lewis N.E., Koellensperger G., Hann S., Nielsen L.K., Borth N., Zanghellini J. What CHO is made of: variations in the biomass composition of Chinese hamster ovary cell lines. Metab. Eng. 61:288-300(2020) | https://en.wikipedia.org/wiki/Chinese_hamster_ovary_cell |
K-562 | CVCL_0004 | Áno | CVCL_J651 (DD) CVCL_6217 (DUTKO-1) CVCL_1G55 (EGFP-K562) CVCL_WU73 (HL-CZ) CVCL_RY26 (K-562 CRISPRa) CVCL_S029 (K-562 SimpleCell O-GalNAc) CVCL_LH52 (K-562-B1-V-2 p17) CVCL_LH51 (K-562-C-1 p365) CVCL_JM00 (K-562-GFP) CVCL_UR39 (K-562-luc2) CVCL_LH50 (K-562-RH) CVCL_5950 (K-562R) CVCL_2967 (K562 AZQR) CVCL_B502 (K562 BZQR) CVCL_2968 (K562 cl.6) CVCL_GZ75 (K562 eGFP-ADNP) CVCL_AW13 (K562 eGFP-ATF1) CVCL_GZ76 (K562 eGFP-ATF3) CVCL_AW14 (K562 eGFP-BACH1) CVCL_AW15 (K562 eGFP-CEBPB) CVCL_GZ77 (K562 eGFP-CEBPG) CVCL_AW16 (K562 eGFP-CREB3) CVCL_GZ78 (K562 eGFP-CUX1) CVCL_AW17 (K562 eGFP-DDX20) CVCL_AW18 (K562 eGFP-DIDO1) CVCL_AW19 (K562 eGFP-E2F1) CVCL_GZ79 (K562 eGFP-E2F4) CVCL_GZ80 (K562 eGFP-E2F5) CVCL_GZ81 (K562 eGFP-ELF1) CVCL_GZ82 (K562 eGFP-ELK1) CVCL_GZ83 (K562 eGFP-ETS2) CVCL_AW20 (K562 eGFP-ETV1) CVCL_AW21 (K562 eGFP-FOS) CVCL_GZ84 (K562 eGFP-FOSL1) CVCL_GZ85 (K562 eGFP-FOXJ2) CVCL_GZ86 (K562 eGFP-GABPA) CVCL_AW22 (K562 eGFP-GATA2) CVCL_GZ87 (K562 eGFP-GTF2A2) CVCL_GZ88 (K562 eGFP-GTF2E2) CVCL_AW23 (K562 eGFP-HDAC8) CVCL_AW24 (K562 eGFP-HINFP) CVCL_AW25 (K562 eGFP-HMGB1) CVCL_AW26 (K562 eGFP-ID3) CVCL_AW27 (K562 eGFP-ILK) CVCL_AW28 (K562 eGFP-IRF1) CVCL_AW29 (K562 eGFP-IRF9) CVCL_AW30 (K562 eGFP-JUNB) CVCL_AW31 (K562 eGFP-JUND) CVCL_AW32 (K562 eGFP-KLF1) CVCL_AW33 (K562 eGFP-KLF13) CVCL_AW34 (K562 eGFP-MAFG) CVCL_GZ89 (K562 eGFP-MEF2D) CVCL_GZ90 (K562 eGFP-NFE2) CVCL_AW35 (K562 eGFP-NFE2L1) CVCL_AW36 (K562 eGFP-NR2C1) CVCL_GZ91 (K562 eGFP-NR2C2) CVCL_AW37 (K562 eGFP-NR4A1) CVCL_GZ92 (K562 eGFP-PBX2) CVCL_GZ93 (K562 eGFP-POLR2H) CVCL_AW38 (K562 eGFP-PTRF) CVCL_AW39 (K562 eGFP-PTTG1) CVCL_AW40 (K562 eGFP-PYGO2) CVCL_AW41 (K562 eGFP-RELA) CVCL_AW42 (K562 eGFP-SMARCA1) CVCL_AW43 (K562 eGFP-SMARCA2) CVCL_AW44 (K562 eGFP-TAF7) CVCL_AW45 (K562 eGFP-TEAD2) CVCL_GZ94 (K562 eGFP-TFDP1) CVCL_AW46 (K562 eGFP-TSC22D4) CVCL_GZ95 (K562 eGFP-USF2) CVCL_GZ96 (K562 eGFP-ZBTB11) CVCL_GZ97 (K562 eGFP-ZFX) CVCL_GZ98 (K562 eGFP-ZKSCAN8) CVCL_GZ99 (K562 eGFP-ZNF148) CVCL_HA00 (K562 eGFP-ZNF175) CVCL_HA01 (K562 eGFP-ZNF197) CVCL_AW47 (K562 eGFP-ZNF24) CVCL_XW96 (K562 eGFP-ZNF354B) CVCL_HA02 (K562 eGFP-ZNF395) CVCL_XW97 (K562 eGFP-ZNF507) CVCL_HA03 (K562 eGFP-ZNF512) CVCL_HA04 (K562 eGFP-ZNF584) CVCL_HA05 (K562 eGFP-ZNF589) CVCL_HA06 (K562 eGFP-ZNF639) CVCL_HA07 (K562 eGFP-ZNF644) CVCL_HA08 (K562 eGFP-ZNF740) CVCL_HA09 (K562 eGFP-ZNF766) CVCL_HA10 (K562 eGFP-ZNF83) CVCL_AW48 (K562 eGFP-ZSCAN9) CVCL_IM25 (K562 HHT) CVCL_ZL53 (K562 NGLY1 KO c15) CVCL_ZL54 (K562 NGLY1 KO c20) CVCL_9120 (K562(A)) CVCL_9119 (K562(S)) CVCL_Z732 (K562-ARA-C) CVCL_JX91 (K562-AVB3) CVCL_4V54 (K562-BMS-R) CVCL_Z733 (K562-CdA) CVCL_4V59 (K562-DAS[r]) CVCL_Z734 (K562-FLUD) CVCL_Z735 (K562-GEM) CVCL_9121 (K562-H) CVCL_4V60 (K562-IMA[r]) CVCL_4V61 (K562-IMA[r]+DAS[r]) CVCL_4V62 (K562-IMA[r]+PON[r]) CVCL_D201 (K562-IMR) CVCL_9122 (K562-L) CVCL_J257 (K562-Luc) CVCL_5J21 (K562-luc2) CVCL_D162 (K562-Lucena 1) CVCL_4V63 (K562-NIL[r]) CVCL_4V64 (K562-PON[r]) CVCL_UC14 (K562-r) CVCL_5J01 (K562-Red-FLuc) CVCL_DP55 (K562-rn) CVCL_UC15 (K562-s) CVCL_XE50 (K562-Wnt5a) CVCL_0368 (K562/A02) CVCL_Y198 (K562/AC) CVCL_3827 (K562/Adr) CVCL_4V20 (K562/ara-C) CVCL_4V84 (K562/AS-3) CVCL_4V85 (K562/AS2) CVCL_AZ73 (K562/CP) CVCL_D205 (K562/D1-9) CVCL_WI19 (K562/DAC) CVCL_4T87 (K562/DNR) CVCL_Y168 (K562/etop20) CVCL_Y169 (K562/etop80) CVCL_4V47 (K562/G01) CVCL_5144 (K562/MTX-2) CVCL_KS44 (K562/NFAT-luc) CVCL_4V51 (K562/NIL-50) CVCL_D573 (K562/R7) CVCL_5145 (K562/Vin) CVCL_S663 (K562/ZD1694.C) CVCL_0369 (K562YO) CVCL_9V30 (KDI/20) CVCL_3000 (KO51) CVCL_IQ44 (NM-D4) CVCL_IQ45 (NM-F9) CVCL_L434 (P2UR/K-562) CVCL_1Q81 (PC-MDS) CVCL_2697 (PUTKO) CVCL_8463 (RM10) CVCL_8423 (RS-1 [Human leukemia]) CVCL_8440 (SAM-1) CVCL_2200 (SPI-801) CVCL_2201 (SPI-802) CVCL_8427 (T-33) CVCL_L806 (TI-1 [Human leukemia]) | človek | Homo sapiens | ľudská | etická | K562; K.562; K 562; KO; GM05372; GM05372E | Bunková línia využívaná pri produkcii vakcín | / | / | Rakovinové bunkové línie | pľúcny kacinóm | ženské | dospelé | 53 rokov | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 1. Part of: LL-100 blood cancer cell line panel. Part of: MD Anderson Cell Lines Project. Part of: NCI-60 cancer cell line panel. Doubling time: 47 hours (PubMed=25984343); 19.6 hours (NCI-DTP); ~30-40 hours (DSMZ). Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger). Omics: Array-based CGH. Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep quantitative phosphoproteome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Fluorescence phenotype profiling. Omics: Genome sequenced. Omics: H2A.Z; ChIP-seq epigenome analysis. Omics: H3K27ac ChIP-seq epigenome analysis. Omics: H3K27me3 ChIP-seq epigenome analysis. Omics: H3K36me3 ChIP-seq epigenome analysis. Omics: H3K4me1 ChIP-seq epigenome analysis. Omics: H3K4me2 ChIP-seq epigenome analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K79me2 ChIP-seq epigenome analysis. Omics: H3K9ac ChIP-seq epigenome analysis. Omics: H3K9me1 ChIP-seq epigenome analysis. Omics: H3K9me3 ChIP-seq epigenome analysis. Omics: H4K20me1 ChIP-seq epigenome analysis. Omics: Pol2; ChIP-seq epigenome analysis. Omics: lncRNA expression profiling. Omics: Metabolome analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis. Omics: Virome analysis using proteomics. Misspelling: K-652; In Cosmic 1523829. Misspelling: K652; In Cosmic 1516632 and Cosmic 2024372. Derived from sampling site: Pleural effusion. | PubMed=163658; DOI=10.1182/blood.V45.3.321.321 Lozzio C.B., Lozzio B.B. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45:321-334(1975) PubMed=924690; DOI=10.1002/ijc.2910200505 Kerbel R.S., Pross H.F., Leibovitz A. Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors. Int. J. Cancer 20:673-679(1977) PubMed=367973; DOI=10.1002/ijc.2910230202 Andersson L.C., Nilsson K., Gahmberg C.G. K562 -- a human erythroleukemic cell line. Int. J. Cancer 23:143-147(1979) PubMed=528075; DOI=10.1002/ijc.2910240422 Andersson L.C., Jokinen M., Gahmberg C.G., Klein E., Klein G., Nilsson K. Presence of erythrocytic components in the K562 cell line. Int. J. Cancer 24:514-514(1979) PubMed=570644; DOI=10.1038/278364a0 Andersson L.C., Jokinen M., Gahmberg C.G. Induction of erythroid differentiation in the human leukaemia cell line K562. Nature 278:364-365(1979) PubMed=6996765; DOI=10.1182/blood.V56.3.344.344 Koeffler H.P., Golde D.W. Human myeloid leukemia cell lines: a review. Blood 56:344-350(1980) PubMed=7194480; DOI=10.3181/00379727-166-41106 Lozzio B.B., Lozzio C.B., Bamberger E.G., Feliu A.S. A multipotential leukemia cell line (K-562) of human origin. Proc. Soc. Exp. Biol. Med. 166:546-550(1981) PubMed=6954533; DOI=10.1073/pnas.79.7.2194 Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., Aaronson S.A., Wong-Staal F. Differential expression of the amv gene in human hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982) PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059 Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G. Lineage infidelity of a human myelogenous leukemia cell line. Blood 64:1059-1063(1984) PubMed=6582512; DOI=10.1073/pnas.81.2.568 Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O. Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies. Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984) PubMed=3856862; DOI=10.1073/pnas.82.6.1810 Konopka J.B., Watanabe S.M., Singer J.W., Collins S.J., Witte O.N. Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration. Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985) PubMed=3857109; DOI=10.1016/0165-4608(85)90101-3 Chen T.-R. Modal karyotype of human leukemia cell line, K562 (ATCC CCL 243). Cancer Genet. Cytogenet. 17:55-60(1985) PubMed=3023859; DOI=10.1128/MCB.6.2.607 Grosveld G., Verwoerd T., van Agthoven T., de Klein A., Ramachandran K.L., Heisterkamp N., Stam K., Groffen J. The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. Mol. Cell. Biol. 6:607-616(1986) PubMed=2446768; DOI=10.1007/BF02797342 Walter H., Al-Romaihi F.A., Krob E.J., Seaman G.V.F. Fractionation of K-562 cells on the basis of their surface properties by partitioning in two-polymer aqueous-phase systems. Cell Biophys. 10:217-232(1987) PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9 Keating A. Ph positive CML cell lines. Baillieres Clin. Haematol. 1:1021-1029(1987) PubMed=2465826; DOI=10.1007/BF02918374 Walter H., Krob E.J., Al-Romaihi F.A., Johnson D., Lozzio C.B. Detection of surface differences between closely related cell populations by partitioning. Cultured K-562 cell sublines. Cell Biophys. 13:173-187(1988) PubMed=3335022 Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589-601(1988) PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x Nakano A., Harada T., Morikawa S., Kato Y. Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines. Acta Pathol. Jpn. 40:107-115(1990) PubMed=2041050; DOI=10.1093/jnci/83.11.757 Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K., Vistica D.T., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst. 83:757-766(1991) CLPUB00447 Mulivor R.A., Suchy S.F. 1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992. (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992) PubMed=8558913 Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T. Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture. Leukemia 10:102-105(1996) PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog. 19:243-253(1997) PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H. Frameshift mutations of the hMSH6 gene in human leukemia cell lines. Jpn. J. Cancer Res. 89:33-39(1998) PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. Jpn. J. Cancer Res. 89:712-718(1998) PubMed=10700174; DOI=10.1038/73432 Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V., Jeffrey S.S., van de Rijn M., Waltham M., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O. Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet. 24:227-235(2000) PubMed=11021758; DOI=10.1038/sj.leu.2401891 Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z. Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia 14:1821-1832(2000) DOI=10.1016/B978-0-12-221970-2.50457-5 Drexler H.G. The leukemia-lymphoma cell line factsbook. (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001) PubMed=11248328; DOI=10.1016/s0145-2126(00)00125-9 Naumann S., Reutzel D., Speicher M., Decker H.-J. Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluorescence in situ hybridization, and comparative genomic hybridization. Leuk. Res. 25:313-322(2001) PubMed=12506034; DOI=10.1182/blood-2002-06-1770 Uno K., Inukai T., Kayagaki N., Goi K., Sato H., Nemoto A., Takahashi K., Kagami K., Yamaguchi N., Yagita H., Okumura K., Koyama-Okazaki T., Suzuki T., Sugita K., Nakazawa S. TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101:3658-3667(2003) PubMed=14642717; DOI=10.1016/j.forsciint.2003.09.002 Szibor R., Edelmann J., Hering S., Plate I., Wittig H., Roewer L., Wiegand P., Cali F., Romano V., Michael M. Cell line DNA typing in forensic genetics -- the necessity of reliable standards. Forensic Sci. Int. 138:37-43(2003) PubMed=15637111; DOI=10.1096/fj.04-3062fje Parson W., Kirchebner R., Muhlmann R., Renner K., Kofler A., Schmidt S., Kofler R. Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB J. 19:434-436(2005) PubMed=15748285; DOI=10.1186/1479-5876-3-11 Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. III, Stroncek D., Marincola F.M. HLA class I and II genotype of the NCI-60 cell lines. J. Transl. Med. 3:11-11(2005) PubMed=15843827; DOI=10.1038/sj.leu.2403749 Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T. Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. Leukemia 19:1042-1050(2005) PubMed=16408098; DOI=10.1038/sj.leu.2404081 Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G. JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders. Leukemia 20:471-476(2006) PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433 Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Mironenko T., Parker A., Perry J., Raine K., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol. Cancer Ther. 5:2606-2612(2006) PubMed=18277095; DOI=10.4161/cbt.7.5.5712 Berglind H., Pawitan Y., Kato S., Ishioka C., Soussi T. Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination. Cancer Biol. Ther. 7:699-708(2008) PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921 Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N. DNA fingerprinting of the NCI-60 cell line panel. Mol. Cancer Ther. 8:713-724(2009) PubMed=20164919; DOI=10.1038/nature08768 Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R. Signatures of mutation and selection in the cancer genome. Nature 463:893-898(2010) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) PubMed=21269460; DOI=10.1186/1752-0509-5-17 Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J. Initial characterization of the human central proteome. BMC Syst. Biol. 5:17-17(2011) PubMed=21552520; DOI=10.1371/journal.pone.0019169 Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S., Tucker M., Kornhauser J., Ren J., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D. Survey of activated FLT3 signaling in leukemia. PLoS ONE 6:E19169-E19169(2011) PubMed=22068913; DOI=10.1073/pnas.1111840108 Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J., Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V., Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R., Ambudkar S.V., Gottesman M.M. Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011) PubMed=22278370; DOI=10.1074/mcp.M111.014050 Geiger T., Wehner A., Schaab C., Cox J., Mann M. Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012) PubMed=22384151; DOI=10.1371/journal.pone.0032096 Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H., Yoon C.N., Chang Y.-T. Identification of cancer cell-line origins using fluorescence image-based phenomic screening. PLoS ONE 7:E32096-E32096(2012) PubMed=22460905; DOI=10.1038/nature11003 Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483:603-607(2012) PubMed=22628656; DOI=10.1126/science.1218595 Jain M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza A.L., Kafri R., Kirschner M.W., Clish C.B., Mootha V.K. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336:1040-1044(2012) PubMed=23325432; DOI=10.1101/gr.147942.112 Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M. Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res. 23:555-567(2013) PubMed=23671654; DOI=10.1371/journal.pone.0063056 Lu Y., Soong T.D., Elemento O. A novel approach for characterizing microsatellite instability in cancer cells. PLoS ONE 8:E63056-E63056(2013) PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342 Abaan O.D., Polley E.C., Davis S.R., Zhu Y.J., Bilke S., Walker R.L., Pineda M., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 73:4372-4382(2013) PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018 Moghaddas Gholami A., Hahne H., Wu Z., Auer F.J., Meng C., Wilhelm M., Kuster B. Global proteome analysis of the NCI-60 cell line panel. Cell Rep. 4:609-620(2013) PubMed=23955599; DOI=10.1038/ng.2731 Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat. Genet. 45:1232-1237(2013) PubMed=24279929; DOI=10.1186/2049-3002-1-20 Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A. The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer Metab. 1:20-20(2013) PubMed=24618588; DOI=10.1371/journal.pone.0091433 Chernobrovkin A.L., Zubarev R.A. Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins. PLoS ONE 9:E91433-E91433(2014) PubMed=24670534; DOI=10.1371/journal.pone.0092047 Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C. High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner. PLoS ONE 9:E92047-E92047(2014) PubMed=25960936; DOI=10.4161/21624011.2014.954893 Boegel S., Lower M., Bukur T., Sahin U., Castle J.C. A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. OncoImmunology 3:E954893-E954893(2014) PubMed=25984343; DOI=10.1038/sdata.2014.35 Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci. Data 1:140035-140035(2014) PubMed=25485619; DOI=10.1038/nbt.3080 Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z. A comprehensive transcriptional portrait of human cancer cell lines. Nat. Biotechnol. 33:306-312(2015) PubMed=27377824; DOI=10.1038/sdata.2016.52 Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J. Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR. Sci. Data 3:160052-160052(2016) PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J. A landscape of pharmacogenomic interactions in cancer. Cell 166:740-754(2016) PubMed=27807467; DOI=10.1186/s13100-016-0078-4 Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H. A map of mobile DNA insertions in the NCI-60 human cancer cell panel. Mob. DNA 7:20-20(2016) PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H. Characterization of human cancer cell lines by reverse-phase protein arrays. Cancer Cell 31:225-239(2017) PubMed=29509191; DOI=10.1038/sdata.2018.30 Mchaourab Z.F., Perreault A.A., Venters B.J. ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells. Sci. Data 5:180030-180030(2018) PubMed=30285677; DOI=10.1186/s12885-018-4840-5 Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P. Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines. BMC Cancer 18:940-940(2018) PubMed=30737237; DOI=10.1101/gr.234948.118 Zhou B., Ho S.S., Greer S.U., Zhu X., Bell J.M., Arthur J.G., Spies N., Zhang X., Byeon S., Pattni R., Ben-Efraim N., Haney M.S., Haraksingh R.R., Song G., Ji H.P., Perrin D., Wong W.H., Abyzov A., Urban A.E. Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562. Genome Res. 29:472-484(2019) PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. Cancer Res. 79:1263-1273(2019) PubMed=31068700; DOI=10.1038/s41586-019-1186-3 Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019) PubMed=31160637; DOI=10.1038/s41598-019-44491-x Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G. The LL-100 panel: 100 cell lines for blood cancer studies. Sci. Rep. 9:8218-8218(2019) PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P. Quantitative proteomics of the Cancer Cell Line Encyclopedia. Cell 180:387-402.e16(2020) PubMed=32449352; DOI=10.1021/acs.jproteome.0c00254 Cao X.-W., Khitun A., Na Z.-K., Dumitrescu D.G., Kubica M., Olatunji E., Slavoff S.A. Comparative proteomic profiling of unannotated microproteins and alternative proteins in human cell lines. J. Proteome Res. 19:3418-3426(2020) | https://en.wikipedia.org/wiki/K562_cells |